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The map label for this gene is nadC [H]

Identifier: 103486638

GI number: 103486638

Start: 1185928

End: 1186845

Strand: Direct

Name: nadC [H]

Synonym: Sala_1150

Alternate gene names: 103486638

Gene position: 1185928-1186845 (Clockwise)

Preceding gene: 103486636

Following gene: 103486639

Centisome position: 35.45

GC content: 65.47

Gene sequence:

>918_bases
ATGGGTCCTGACCCTAGTTTACGTAAACGTCAAGTTGATTTGCTGGACGGGCGGATTATCGCGGGTTGCATGACCCAGTT
TCCCATGCCCGGTTTCGACCTCGAGGCTTTCGTCCGTGCCACGCTGGCCGAGGATCTGGGCGCGGGGGGCGATATTACGT
CGTTGGCGACGATCCCCGCCGATGCGCGCTTCGACGGTGTAATGGACAGCCGCGACGCGATCACCGTCGCCGGCCTGCCG
ATCGCCGAGCGATTCTTCCGCGCGCTCGATCCGGCGATGGAAATCGAGATCCTGGCCGAAGAGGGCGCAGAAGTTCCTGC
GGGCAGCGATGTGATGCGCCTGTCGGGCAATGCGCGCGCGATGCTGACCGCCGAGCGGTCGGCGCTCAACACGGTGCAGC
ATCTGTCGGGGATCGCGACGATGACGCGCCAATATGTCGATGCGATCGCGGGAACAGGGGCGACGCTGCTCGACACGCGC
AAGACGATACCCGGCCTGCGGGTGCTCGAAAAATATGCGACGCGGATGGGCGGGGCGAAGAATCACCGCATGGGCCTGTG
GGACGCGGCGATGATCAAGGATAATCACGTCGCGGTCGCGGGATCGGTCGAGGAAGCGGTGCGGCGGGCGGTGGAGGCGG
GAATCGCCGACATCATCGTTGAAGTCGACCGTGTGGCGCAGGTCGAACCGGCACTGGTCGCGGGAGCGACGCATCTGCTG
CTCGACAATATGGGCCTCGACGATCTGCGCACCAGCGTCGCGATTGTCGATGGCAGGGTGCCGACCGAGGCGTCGGGCGG
GGTGCGGCTCGACACGATCCGCGCGATCGCCGAAACGGGCGTCACCTATGTATCGGTCGGGCGCCTAACCCAGTCGGCGC
CCGCGGCCGACATCGGGCTCGATTTTGCGCTGGCTTAG

Upstream 100 bases:

>100_bases
TGCCCATGGCAGCGTCGAAAAGCCTTGAAATATATCCATATTCCTGCGCCTTTCCTCCTCGCCCTGAGCAAAATCGCCTC
AAACCTCGAACGGGTAATTA

Downstream 100 bases:

>100_bases
TGCCGCCGCGTTGACGCTGATGCCCGTCGCGGCGCAGGCGCAGGCGCTAGCCTGCTCGGTGCCCGATCGGATTCCCGTGC
CGCGCCTCGAACAGCCGCGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGPDPSLRKRQVDLLDGRIIAGCMTQFPMPGFDLEAFVRATLAEDLGAGGDITSLATIPADARFDGVMDSRDAITVAGLP
IAERFFRALDPAMEIEILAEEGAEVPAGSDVMRLSGNARAMLTAERSALNTVQHLSGIATMTRQYVDAIAGTGATLLDTR
KTIPGLRVLEKYATRMGGAKNHRMGLWDAAMIKDNHVAVAGSVEEAVRRAVEAGIADIIVEVDRVAQVEPALVAGATHLL
LDNMGLDDLRTSVAIVDGRVPTEASGGVRLDTIRAIAETGVTYVSVGRLTQSAPAADIGLDFALA

Sequences:

>Translated_305_residues
MGPDPSLRKRQVDLLDGRIIAGCMTQFPMPGFDLEAFVRATLAEDLGAGGDITSLATIPADARFDGVMDSRDAITVAGLP
IAERFFRALDPAMEIEILAEEGAEVPAGSDVMRLSGNARAMLTAERSALNTVQHLSGIATMTRQYVDAIAGTGATLLDTR
KTIPGLRVLEKYATRMGGAKNHRMGLWDAAMIKDNHVAVAGSVEEAVRRAVEAGIADIIVEVDRVAQVEPALVAGATHLL
LDNMGLDDLRTSVAIVDGRVPTEASGGVRLDTIRAIAETGVTYVSVGRLTQSAPAADIGLDFALA
>Mature_304_residues
GPDPSLRKRQVDLLDGRIIAGCMTQFPMPGFDLEAFVRATLAEDLGAGGDITSLATIPADARFDGVMDSRDAITVAGLPI
AERFFRALDPAMEIEILAEEGAEVPAGSDVMRLSGNARAMLTAERSALNTVQHLSGIATMTRQYVDAIAGTGATLLDTRK
TIPGLRVLEKYATRMGGAKNHRMGLWDAAMIKDNHVAVAGSVEEAVRRAVEAGIADIIVEVDRVAQVEPALVAGATHLLL
DNMGLDDLRTSVAIVDGRVPTEASGGVRLDTIRAIAETGVTYVSVGRLTQSAPAADIGLDFALA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=281, Percent_Identity=34.1637010676157, Blast_Score=127, Evalue=9e-30,
Organism=Escherichia coli, GI1786299, Length=278, Percent_Identity=39.2086330935252, Blast_Score=163, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=244, Percent_Identity=33.1967213114754, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32089; Mature: 31958

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPDPSLRKRQVDLLDGRIIAGCMTQFPMPGFDLEAFVRATLAEDLGAGGDITSLATIPA
CCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCC
DARFDGVMDSRDAITVAGLPIAERFFRALDPAMEIEILAEEGAEVPAGSDVMRLSGNARA
CCCCCCCCCCCCCEEEECCHHHHHHHHHCCCHHEEEEEECCCCCCCCCCCEEEECCCCEE
MLTAERSALNTVQHLSGIATMTRQYVDAIAGTGATLLDTRKTIPGLRVLEKYATRMGGAK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
NHRMGLWDAAMIKDNHVAVAGSVEEAVRRAVEAGIADIIVEVDRVAQVEPALVAGATHLL
CCCCCCCHHHEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LDNMGLDDLRTSVAIVDGRVPTEASGGVRLDTIRAIAETGVTYVSVGRLTQSAPAADIGL
HHCCCHHHHHHEEEEEECCCCCCCCCCEEHHHHHHHHHCCCEEEEECCHHCCCCCCCCCC
DFALA
EEECC
>Mature Secondary Structure 
GPDPSLRKRQVDLLDGRIIAGCMTQFPMPGFDLEAFVRATLAEDLGAGGDITSLATIPA
CCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCC
DARFDGVMDSRDAITVAGLPIAERFFRALDPAMEIEILAEEGAEVPAGSDVMRLSGNARA
CCCCCCCCCCCCCEEEECCHHHHHHHHHCCCHHEEEEEECCCCCCCCCCCEEEECCCCEE
MLTAERSALNTVQHLSGIATMTRQYVDAIAGTGATLLDTRKTIPGLRVLEKYATRMGGAK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
NHRMGLWDAAMIKDNHVAVAGSVEEAVRRAVEAGIADIIVEVDRVAQVEPALVAGATHLL
CCCCCCCHHHEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LDNMGLDDLRTSVAIVDGRVPTEASGGVRLDTIRAIAETGVTYVSVGRLTQSAPAADIGL
HHCCCHHHHHHEEEEEECCCCCCCCCCEEHHHHHHHHHCCCEEEEECCHHCCCCCCCCCC
DFALA
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]