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The map label for this gene is bioA [C]

Identifier: 103486610

GI number: 103486610

Start: 1159295

End: 1160611

Strand: Direct

Name: bioA [C]

Synonym: Sala_1122

Alternate gene names: 103486610

Gene position: 1159295-1160611 (Clockwise)

Preceding gene: 103486601

Following gene: 103486612

Centisome position: 34.66

GC content: 66.21

Gene sequence:

>1317_bases
ATGAGGGGCGACAACGACCAGCTGGCAAGTTTCTGGATGCCCTTCACCGCGAACCGCGCGTACAAGGCGCAGCCGCGCCA
GCTCGTATCGGCAAGCGGCATGTTTTACCGGTCGAGCGACGGGCGCGACATACTCGACGGCACCGCGGGCCTGTGGTGCA
GCAATGCCGGTCATTGCCGCCCCGAAATCACCGAGGCGATCGCCAGAACCGCGGCGACGCTGGACTTTGCACCGACGTTT
CAGCTGGGGCACCCGCTGCCTTTTGAGCTGGCGCAGCGCCTCGCGGCGTTGATGCCCGACGGGCTCGACCGGATATTCTT
CACCAACAGCGGGTCGGAGTCGGTCGATACGGCGCTCAAAATCGCGCTCGCGATCCAGCGCGCGAAGGGGCAGGGGGCGC
GCACCCGGTTGATCGGGCGCGAACGCGGCTACCACGGCACCGGCTTTGGCGGGATCAGCGTTGGCGGTCTCGTCAACAAC
CGTCGCGCCTTCGGCGGGGGTTTGCCGGGCGTAGACCATCTCCGTCATACGCATGATCTGGAGCGCAACGCTTTCAGTCG
CGGATTCCCGCAGCATGGCGCCGAACTCGCCGACGATCTGCAACGCCTGGTCGATCTGCACGGCGCCGAGACGATCGCTG
CGGTTATCGTCGAACCGATGGCGGGATCGACCGGCGTGCTCGTGCCGCCCGTTGGCTACCTCTCACGCTTGCGCGAGATT
TGCGACCGGCATGGCATCATCCTGATCTTCGACGAAGTCATCACCGCTTTCGGGCGTGTCGGCGGCGCAACGGCGTCGCA
AATGTGGGGCGTGACGCCTGACATCATCACCATGGCCAAGGGCCTGACCAATGCCACGGTGCCGATGGGGGCGGTGGCGG
TGAAGCGCGAGCTGCACGATGCGGTGATCGACAGCGCGCCGGGCGGGATCGAGCTGTTCCACGGCTACACCTATTCAGGC
CACCCCTTGGCGAGCGCGGCGGGGCTGGCGACGCTGGACCTCTATGCCCGCGACGGGCTGTTCGACCGTGCGAGCGAACT
CGGCGCCTATTGGGAGGATGCGGCACACAGCCTGAAGGGGCGGCGGCACGTCATCGACGTCCGCACGATCGGCCTCGTCG
CAGGCATCGAACTTGAACCACGCCCCGGCGCCCCCACCGCGCGCGCGATGGAACTGTTCCACGCCTGTTTCGACAACGGC
CTGCTCGTGCGCGCTACGGGCGATATCATCGCGCTGTCGCCGCCGCTGATCGTCGAGAAGGAACAAATCGACGCAATGTT
CGGGACGATCGCCGACCTCATCGACCGGATCGATTAG

Upstream 100 bases:

>100_bases
TGAAGTCGGGTGAAGCGCCAGAGGGCCGGTTTTGTCCATTGCCAGCGGGGTGGCGGGCCGTCAGATTGGCGCGCAGAAGA
ACCAGAGGAGGCAAGCAGCG

Downstream 100 bases:

>100_bases
GCGCTGGCGGCAAGGGGAAAGCTTATCGAAACGCTGGTTCCCTTGCCCGGTTCGCTGTCGATGTGGAGCTGCCCCTGATG
GCGCTCGCTGATATGCTTGA

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRGDNDQLASFWMPFTANRAYKAQPRQLVSASGMFYRSSDGRDILDGTAGLWCSNAGHCRPEITEAIARTAATLDFAPTF
QLGHPLPFELAQRLAALMPDGLDRIFFTNSGSESVDTALKIALAIQRAKGQGARTRLIGRERGYHGTGFGGISVGGLVNN
RRAFGGGLPGVDHLRHTHDLERNAFSRGFPQHGAELADDLQRLVDLHGAETIAAVIVEPMAGSTGVLVPPVGYLSRLREI
CDRHGIILIFDEVITAFGRVGGATASQMWGVTPDIITMAKGLTNATVPMGAVAVKRELHDAVIDSAPGGIELFHGYTYSG
HPLASAAGLATLDLYARDGLFDRASELGAYWEDAAHSLKGRRHVIDVRTIGLVAGIELEPRPGAPTARAMELFHACFDNG
LLVRATGDIIALSPPLIVEKEQIDAMFGTIADLIDRID

Sequences:

>Translated_438_residues
MRGDNDQLASFWMPFTANRAYKAQPRQLVSASGMFYRSSDGRDILDGTAGLWCSNAGHCRPEITEAIARTAATLDFAPTF
QLGHPLPFELAQRLAALMPDGLDRIFFTNSGSESVDTALKIALAIQRAKGQGARTRLIGRERGYHGTGFGGISVGGLVNN
RRAFGGGLPGVDHLRHTHDLERNAFSRGFPQHGAELADDLQRLVDLHGAETIAAVIVEPMAGSTGVLVPPVGYLSRLREI
CDRHGIILIFDEVITAFGRVGGATASQMWGVTPDIITMAKGLTNATVPMGAVAVKRELHDAVIDSAPGGIELFHGYTYSG
HPLASAAGLATLDLYARDGLFDRASELGAYWEDAAHSLKGRRHVIDVRTIGLVAGIELEPRPGAPTARAMELFHACFDNG
LLVRATGDIIALSPPLIVEKEQIDAMFGTIADLIDRID
>Mature_438_residues
MRGDNDQLASFWMPFTANRAYKAQPRQLVSASGMFYRSSDGRDILDGTAGLWCSNAGHCRPEITEAIARTAATLDFAPTF
QLGHPLPFELAQRLAALMPDGLDRIFFTNSGSESVDTALKIALAIQRAKGQGARTRLIGRERGYHGTGFGGISVGGLVNN
RRAFGGGLPGVDHLRHTHDLERNAFSRGFPQHGAELADDLQRLVDLHGAETIAAVIVEPMAGSTGVLVPPVGYLSRLREI
CDRHGIILIFDEVITAFGRVGGATASQMWGVTPDIITMAKGLTNATVPMGAVAVKRELHDAVIDSAPGGIELFHGYTYSG
HPLASAAGLATLDLYARDGLFDRASELGAYWEDAAHSLKGRRHVIDVRTIGLVAGIELEPRPGAPTARAMELFHACFDNG
LLVRATGDIIALSPPLIVEKEQIDAMFGTIADLIDRID

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=432, Percent_Identity=29.6296296296296, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=30.8080808080808, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI226442705, Length=432, Percent_Identity=29.1666666666667, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=27.7522935779816, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4557809, Length=409, Percent_Identity=26.8948655256724, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI24119277, Length=408, Percent_Identity=26.7156862745098, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=28.6604361370716, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786991, Length=428, Percent_Identity=29.6728971962617, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI145693181, Length=394, Percent_Identity=31.4720812182741, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=30.0733496332518, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789759, Length=425, Percent_Identity=28.2352941176471, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787560, Length=424, Percent_Identity=29.7169811320755, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788044, Length=407, Percent_Identity=28.009828009828, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=28.8184438040346, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=442, Percent_Identity=28.9592760180996, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=25.7683215130024, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=27.906976744186, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=244, Percent_Identity=29.5081967213115, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=432, Percent_Identity=27.7777777777778, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324386, Length=434, Percent_Identity=25.5760368663594, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=25.2955082742317, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=27.8959810874704, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21357415, Length=423, Percent_Identity=25.7683215130024, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI28574759, Length=409, Percent_Identity=28.1173594132029, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=28.8732394366197, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 46937; Mature: 46937

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGDNDQLASFWMPFTANRAYKAQPRQLVSASGMFYRSSDGRDILDGTAGLWCSNAGHCR
CCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCEEEECCCCCCHHCCCCCCEECCCCCCC
PEITEAIARTAATLDFAPTFQLGHPLPFELAQRLAALMPDGLDRIFFTNSGSESVDTALK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
IALAIQRAKGQGARTRLIGRERGYHGTGFGGISVGGLVNNRRAFGGGLPGVDHLRHTHDL
HHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCEEECCEECCCCCCCCCCCCHHHHHHHHHH
ERNAFSRGFPQHGAELADDLQRLVDLHGAETIAAVIVEPMAGSTGVLVPPVGYLSRLREI
HHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHH
CDRHGIILIFDEVITAFGRVGGATASQMWGVTPDIITMAKGLTNATVPMGAVAVKRELHD
HHHCCEEEEHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AVIDSAPGGIELFHGYTYSGHPLASAAGLATLDLYARDGLFDRASELGAYWEDAAHSLKG
HHHCCCCCCEEEEECCCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
RRHVIDVRTIGLVAGIELEPRPGAPTARAMELFHACFDNGLLVRATGDIIALSPPLIVEK
CCEEEEEEEEHEEECCEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCCEEEH
EQIDAMFGTIADLIDRID
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGDNDQLASFWMPFTANRAYKAQPRQLVSASGMFYRSSDGRDILDGTAGLWCSNAGHCR
CCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCEEEECCCCCCHHCCCCCCEECCCCCCC
PEITEAIARTAATLDFAPTFQLGHPLPFELAQRLAALMPDGLDRIFFTNSGSESVDTALK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
IALAIQRAKGQGARTRLIGRERGYHGTGFGGISVGGLVNNRRAFGGGLPGVDHLRHTHDL
HHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCEEECCEECCCCCCCCCCCCHHHHHHHHHH
ERNAFSRGFPQHGAELADDLQRLVDLHGAETIAAVIVEPMAGSTGVLVPPVGYLSRLREI
HHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHH
CDRHGIILIFDEVITAFGRVGGATASQMWGVTPDIITMAKGLTNATVPMGAVAVKRELHD
HHHCCEEEEHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AVIDSAPGGIELFHGYTYSGHPLASAAGLATLDLYARDGLFDRASELGAYWEDAAHSLKG
HHHCCCCCCEEEEECCCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
RRHVIDVRTIGLVAGIELEPRPGAPTARAMELFHACFDNGLLVRATGDIIALSPPLIVEK
CCEEEEEEEEHEEECCEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCCEEEH
EQIDAMFGTIADLIDRID
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]