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The map label for this gene is dltE [H]

Identifier: 103486570

GI number: 103486570

Start: 1110108

End: 1110860

Strand: Reverse

Name: dltE [H]

Synonym: Sala_1081

Alternate gene names: 103486570

Gene position: 1110860-1110108 (Counterclockwise)

Preceding gene: 103486579

Following gene: 103486569

Centisome position: 33.21

GC content: 64.01

Gene sequence:

>753_bases
GTGTGCGCGGCAAAAGCCCATGGGAGGGGTTGCATGAACTTACGCGGAATACTCGCGCTCGTCACCGGCGGCAGCGATGG
CATCGGCCGCGAGATCGCGCTGCAGTTGCAGGCTGCGAGCGCCGATGTGATCGTCACCGGGCGATCGCCGGACAAGTTGC
AGGCGATGGCCGCGCTGGGATTCGGGACCATCGCGGGTGACCTGTCGACAACCGCAGGAATCGACGCGGTGGTTGGCGGC
GTCGTCGGCAAGCCGCTCGCGTTGCTCGTCAACAATGCGGGGATCGGCAGCGATTATGACCTCGATCGACTCGAAACGCT
CGAAAGCGCCAGTCATTGCATTCGCACCAATCTCGACGCACCAGTTGCGCTTTGCACCCGCCTGCTCCCGACCTTGCGCG
CCCGGCCCGAGGCGGCGATCGTCAATATCACCTCCGGCCTCGCGATAGCGCCGCGCGCAGGAAGCGCGATCTATTGCGCG
ACCAAGGCGGGGCTGCGCAGCTATACGCAGGCGATCCGGCATCTGCTGAAGGACAGCAATATCCGCGTGATCGAAGCGCT
GCCGCCCGTCGTCGAAACGAACATGACGGCTGGCCGTGGAGGCAAGAAAATGAGCGCACACGCCTGCGCCGCCGAAATCG
TCCACGGCATCCGCACCGGCAAAAGCGAAGTCAATGTCGGCATGGTGAAAATGCTCCAGCTCGTCCACAGCATCTCGCCC
GCGCTGGCACGGCGGATCATGATCCGGTTTTGA

Upstream 100 bases:

>100_bases
GCCGCGCACGACATAGGTGGCCTTTTCCTCGTTGAACCGGTCGGGAGCGTTGGGGCGAACCATGAATTGCATGTAGGCGA
AGGCGAGGCGAGCCGCCATA

Downstream 100 bases:

>100_bases
CTGGGCGGCTTTGGGGTGGGGTGCGGACGTTCCTCTCTTTCCGTTCGTGTCGAGCGAAGTCGAGACACCCATCGGCGCTA
ATCCTAGCCAGAGGGGCATC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MCAAKAHGRGCMNLRGILALVTGGSDGIGREIALQLQAASADVIVTGRSPDKLQAMAALGFGTIAGDLSTTAGIDAVVGG
VVGKPLALLVNNAGIGSDYDLDRLETLESASHCIRTNLDAPVALCTRLLPTLRARPEAAIVNITSGLAIAPRAGSAIYCA
TKAGLRSYTQAIRHLLKDSNIRVIEALPPVVETNMTAGRGGKKMSAHACAAEIVHGIRTGKSEVNVGMVKMLQLVHSISP
ALARRIMIRF

Sequences:

>Translated_250_residues
MCAAKAHGRGCMNLRGILALVTGGSDGIGREIALQLQAASADVIVTGRSPDKLQAMAALGFGTIAGDLSTTAGIDAVVGG
VVGKPLALLVNNAGIGSDYDLDRLETLESASHCIRTNLDAPVALCTRLLPTLRARPEAAIVNITSGLAIAPRAGSAIYCA
TKAGLRSYTQAIRHLLKDSNIRVIEALPPVVETNMTAGRGGKKMSAHACAAEIVHGIRTGKSEVNVGMVKMLQLVHSISP
ALARRIMIRF
>Mature_250_residues
MCAAKAHGRGCMNLRGILALVTGGSDGIGREIALQLQAASADVIVTGRSPDKLQAMAALGFGTIAGDLSTTAGIDAVVGG
VVGKPLALLVNNAGIGSDYDLDRLETLESASHCIRTNLDAPVALCTRLLPTLRARPEAAIVNITSGLAIAPRAGSAIYCA
TKAGLRSYTQAIRHLLKDSNIRVIEALPPVVETNMTAGRGGKKMSAHACAAEIVHGIRTGKSEVNVGMVKMLQLVHSISP
ALARRIMIRF

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG3967

COG function: function code M; Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705855, Length=199, Percent_Identity=28.643216080402, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI4557649, Length=193, Percent_Identity=26.4248704663212, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI226371731, Length=191, Percent_Identity=28.7958115183246, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1787335, Length=191, Percent_Identity=33.5078534031414, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786701, Length=180, Percent_Identity=29.4444444444444, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787820, Length=241, Percent_Identity=26.1410788381743, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=184, Percent_Identity=34.2391304347826, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=197, Percent_Identity=28.9340101522843, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=243, Percent_Identity=29.6296296296296, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=200, Percent_Identity=29.5, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=199, Percent_Identity=29.6482412060301, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=196, Percent_Identity=31.6326530612245, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24584752, Length=219, Percent_Identity=32.4200913242009, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24643142, Length=188, Percent_Identity=34.5744680851064, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584748, Length=194, Percent_Identity=27.319587628866, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076933, Length=194, Percent_Identity=27.319587628866, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584744, Length=202, Percent_Identity=25.7425742574257, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28574402, Length=202, Percent_Identity=25.7425742574257, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=32.6424870466321, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25909; Mature: 25909

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAAKAHGRGCMNLRGILALVTGGSDGIGREIALQLQAASADVIVTGRSPDKLQAMAALG
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEECCCCHHHHHHHHHC
FGTIAGDLSTTAGIDAVVGGVVGKPLALLVNNAGIGSDYDLDRLETLESASHCIRTNLDA
CHHHHCCCCHHCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
PVALCTRLLPTLRARPEAAIVNITSGLAIAPRAGSAIYCATKAGLRSYTQAIRHLLKDSN
HHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCC
IRVIEALPPVVETNMTAGRGGKKMSAHACAAEIVHGIRTGKSEVNVGMVKMLQLVHSISP
EEEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCH
ALARRIMIRF
HHHHHHHHCC
>Mature Secondary Structure
MCAAKAHGRGCMNLRGILALVTGGSDGIGREIALQLQAASADVIVTGRSPDKLQAMAALG
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCEEEECCCCHHHHHHHHHC
FGTIAGDLSTTAGIDAVVGGVVGKPLALLVNNAGIGSDYDLDRLETLESASHCIRTNLDA
CHHHHCCCCHHCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
PVALCTRLLPTLRARPEAAIVNITSGLAIAPRAGSAIYCATKAGLRSYTQAIRHLLKDSN
HHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCC
IRVIEALPPVVETNMTAGRGGKKMSAHACAAEIVHGIRTGKSEVNVGMVKMLQLVHSISP
EEEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCH
ALARRIMIRF
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 7797557 [H]