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The map label for this gene is atoC [H]

Identifier: 103486440

GI number: 103486440

Start: 974126

End: 975502

Strand: Direct

Name: atoC [H]

Synonym: Sala_0950

Alternate gene names: 103486440

Gene position: 974126-975502 (Clockwise)

Preceding gene: 103486439

Following gene: 103486441

Centisome position: 29.12

GC content: 64.63

Gene sequence:

>1377_bases
ATGAACGAAACGGCGGCAGCCCGTCGCAAACTGCTGGTGGTCGAGGATGATCCGGGGCTGCAGACGCAGCTCAAATGGGC
CTATGAAGATTATCAGGTGTTCGTCGCGGGCGACCATGACACGGCGATCGAACTGCTGCGCGCCGAGGAACCCGATGTCG
TGACGCTCGACCTGGGGTTGCCGCCCGACCCCGACGGCACGCGCGAGGGGTTCCGCACGCTGAAAACCATCGTCGAAGCG
AAACCCGATACCAAGGTGATCGTCGTGTCGGGCCATGGCGAACGCGCCAGCGCATTGAACGCGATCGCCAGCGGCGCGTG
GGATTTTTATCAGAAGCCGATCGACATCGACGCGCTGGGGCTGATCGTCGCGCGCGCCTTTCACGTCCGCGAACTGGAGG
TCGAGAATGCGCGGCTGGCCAGCCAGGGCGCCCGCGACAATCGCGTGCTCGGTGGAATGATCACCGGCGCGCCCGAAATG
CTCAAGGTGGCGCGCACGATCGAGCGCGTCGCGAACCTCGACGTATCGGTGATGCTGCTCGGAGCGAGCGGGACGGGCAA
GGAACTGCTTGCGCGCGGGCTGCACGAGGCAAGCGCGCGGCGCGACGGGGCGTTCGTCGCGATCAATTGCGCCGCGATCC
CCGAAAACCTGCTTGAAAGCGAATTGTTCGGGCATGAAAAAGGCGCGTTCACCGGCGCGGTCAAGACGACCGAAGGCAAG
ATCGAACTGGCGCACGGCGGCACGCTTTTTCTCGACGAGGTCGGCGACATTCCGCTGTCGTTGCAGGTCAAGCTGCTGCG
ATTCCTGCAGGAGCGGACAATCGAGCGGATCGGCGGGCGCAAGGCGATTGCGGTCGATACGCGAATCGTCTGTGCGACGC
ACCGCGACCTCGACGCCATGCTCGCCGCGCAAAGCTTTCGCGACGATCTTTATTACCGGCTTGCCGAAATGGTCGTGAAG
ATTCCGTCGCTCGCCGAACGGCCGGGCGACGCGGTGCTGCTCGCGCGGCATTTCCTTCATCAATATGCACCCGAAATGAA
CCCCGGCGTGCGCGGCTTTGCACCCGACGCGCTACAGGCCATCGACGAAGCCCGCTGGCCGGGCAATGTCCGCGAGCTGG
AAAACCGGATCAAGCGCGCGGTCATCATGGCCGATGGCAAGCTGGTGACGCGCGGGGACCTCGACATGGCCGGCGCTGCG
GAAGAGGAGGAGGATATGTGGCTCAACCTGCGCAGCGCGCGCGAGGCAGCCGACCGCGTCGCGATCCGCCGCGCGATGAC
ACAGAGCGAGGGCAATATCTCGCACGCGGCCAAGCTGCTGGGGATCAGTCGCCCGACGCTTTACGACCTGCTCAAACAAT
ATCGGATGCAGGGCTGA

Upstream 100 bases:

>100_bases
GCGAAGTCGGCGAAGGAAGCAATTTCACATTGTGGCTGCCGCTCGCCGACGCGTCCAGCGCCGCGGTGGTTGACGCGCGG
GCGATCAATGGGGGGCGGAC

Downstream 100 bases:

>100_bases
ATGGGCTTTCGCCGCGTCTGGACGGGCGCGCTGCTGATCGCGGCGTCGCTTTCGGCGTGCGGCGGCGCGTCCGACACGCC
GCGCGGCGAGATGGAGGCGC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNETAAARRKLLVVEDDPGLQTQLKWAYEDYQVFVAGDHDTAIELLRAEEPDVVTLDLGLPPDPDGTREGFRTLKTIVEA
KPDTKVIVVSGHGERASALNAIASGAWDFYQKPIDIDALGLIVARAFHVRELEVENARLASQGARDNRVLGGMITGAPEM
LKVARTIERVANLDVSVMLLGASGTGKELLARGLHEASARRDGAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGK
IELAHGGTLFLDEVGDIPLSLQVKLLRFLQERTIERIGGRKAIAVDTRIVCATHRDLDAMLAAQSFRDDLYYRLAEMVVK
IPSLAERPGDAVLLARHFLHQYAPEMNPGVRGFAPDALQAIDEARWPGNVRELENRIKRAVIMADGKLVTRGDLDMAGAA
EEEEDMWLNLRSAREAADRVAIRRAMTQSEGNISHAAKLLGISRPTLYDLLKQYRMQG

Sequences:

>Translated_458_residues
MNETAAARRKLLVVEDDPGLQTQLKWAYEDYQVFVAGDHDTAIELLRAEEPDVVTLDLGLPPDPDGTREGFRTLKTIVEA
KPDTKVIVVSGHGERASALNAIASGAWDFYQKPIDIDALGLIVARAFHVRELEVENARLASQGARDNRVLGGMITGAPEM
LKVARTIERVANLDVSVMLLGASGTGKELLARGLHEASARRDGAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGK
IELAHGGTLFLDEVGDIPLSLQVKLLRFLQERTIERIGGRKAIAVDTRIVCATHRDLDAMLAAQSFRDDLYYRLAEMVVK
IPSLAERPGDAVLLARHFLHQYAPEMNPGVRGFAPDALQAIDEARWPGNVRELENRIKRAVIMADGKLVTRGDLDMAGAA
EEEEDMWLNLRSAREAADRVAIRRAMTQSEGNISHAAKLLGISRPTLYDLLKQYRMQG
>Mature_458_residues
MNETAAARRKLLVVEDDPGLQTQLKWAYEDYQVFVAGDHDTAIELLRAEEPDVVTLDLGLPPDPDGTREGFRTLKTIVEA
KPDTKVIVVSGHGERASALNAIASGAWDFYQKPIDIDALGLIVARAFHVRELEVENARLASQGARDNRVLGGMITGAPEM
LKVARTIERVANLDVSVMLLGASGTGKELLARGLHEASARRDGAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGK
IELAHGGTLFLDEVGDIPLSLQVKLLRFLQERTIERIGGRKAIAVDTRIVCATHRDLDAMLAAQSFRDDLYYRLAEMVVK
IPSLAERPGDAVLLARHFLHQYAPEMNPGVRGFAPDALQAIDEARWPGNVRELENRIKRAVIMADGKLVTRGDLDMAGAA
EEEEDMWLNLRSAREAADRVAIRRAMTQSEGNISHAAKLLGISRPTLYDLLKQYRMQG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=38.9978213507625, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1788905, Length=448, Percent_Identity=40.1785714285714, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1790437, Length=449, Percent_Identity=39.6436525612472, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI1790299, Length=444, Percent_Identity=37.1621621621622, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082117, Length=256, Percent_Identity=49.609375, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789087, Length=323, Percent_Identity=42.1052631578947, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1789233, Length=367, Percent_Identity=38.1471389645777, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=39.375, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082152, Length=315, Percent_Identity=40.9523809523809, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=38.8198757763975, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=32.9192546583851, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789828, Length=250, Percent_Identity=34, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081858, Length=332, Percent_Identity=27.710843373494, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50222; Mature: 50222

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETAAARRKLLVVEDDPGLQTQLKWAYEDYQVFVAGDHDTAIELLRAEEPDVVTLDLGL
CCCCHHHHCEEEEEECCCCCCCEEEEEEECEEEEEECCCHHHHHHHHCCCCCEEEEECCC
PPDPDGTREGFRTLKTIVEAKPDTKVIVVSGHGERASALNAIASGAWDFYQKPIDIDALG
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCHHHHH
LIVARAFHVRELEVENARLASQGARDNRVLGGMITGAPEMLKVARTIERVANLDVSVMLL
HHHHHHHHHHEEECCCHHHHHCCCCCCCEECEEECCCHHHHHHHHHHHHHHCCCEEEEEE
GASGTGKELLARGLHEASARRDGAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGK
ECCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCEECEEEECCCE
IELAHGGTLFLDEVGDIPLSLQVKLLRFLQERTIERIGGRKAIAVDTRIVCATHRDLDAM
EEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCHHHH
LAAQSFRDDLYYRLAEMVVKIPSLAERPGDAVLLARHFLHQYAPEMNPGVRGFAPDALQA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
IDEARWPGNVRELENRIKRAVIMADGKLVTRGDLDMAGAAEEEEDMWLNLRSAREAADRV
HHHHCCCCCHHHHHHHHHHEEEEECCEEEEECCCCCCCCCCCCHHHHEEHHHHHHHHHHH
AIRRAMTQSEGNISHAAKLLGISRPTLYDLLKQYRMQG
HHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNETAAARRKLLVVEDDPGLQTQLKWAYEDYQVFVAGDHDTAIELLRAEEPDVVTLDLGL
CCCCHHHHCEEEEEECCCCCCCEEEEEEECEEEEEECCCHHHHHHHHCCCCCEEEEECCC
PPDPDGTREGFRTLKTIVEAKPDTKVIVVSGHGERASALNAIASGAWDFYQKPIDIDALG
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCHHHHH
LIVARAFHVRELEVENARLASQGARDNRVLGGMITGAPEMLKVARTIERVANLDVSVMLL
HHHHHHHHHHEEECCCHHHHHCCCCCCCEECEEECCCHHHHHHHHHHHHHHCCCEEEEEE
GASGTGKELLARGLHEASARRDGAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGK
ECCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCEECEEEECCCE
IELAHGGTLFLDEVGDIPLSLQVKLLRFLQERTIERIGGRKAIAVDTRIVCATHRDLDAM
EEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCHHHH
LAAQSFRDDLYYRLAEMVVKIPSLAERPGDAVLLARHFLHQYAPEMNPGVRGFAPDALQA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
IDEARWPGNVRELENRIKRAVIMADGKLVTRGDLDMAGAAEEEEDMWLNLRSAREAADRV
HHHHCCCCCHHHHHHHHHHEEEEECCEEEEECCCCCCCCCCCCHHHHEEHHHHHHHHHHH
AIRRAMTQSEGNISHAAKLLGISRPTLYDLLKQYRMQG
HHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]