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The map label for this gene is zraS [H]

Identifier: 103486439

GI number: 103486439

Start: 972009

End: 974129

Strand: Direct

Name: zraS [H]

Synonym: Sala_0949

Alternate gene names: 103486439

Gene position: 972009-974129 (Clockwise)

Preceding gene: 103486438

Following gene: 103486440

Centisome position: 29.06

GC content: 68.65

Gene sequence:

>2121_bases
GTGGCGGCAATGGACGGCCTTTCGCAGCTTTTGTCAGGCATGGCGCTCGTCGGCTTTGCCGGAGCGGCGCTGTGGCTGCT
GTTGCGGCCCCGCGCGCGCATGGCGGCGTTGATGCCCGCGCCGCGCCTGCTTGCGCTGGGGGCGGCGACGACGGCGCTGT
GGGCGGCGGCCATGATGCGCTTTACACCGGGTGCGCCGCAGGTGCTGGTGGTGCAGACGCTGCGCGACGCGGCGATGCTT
GTCTGGCTCGGCGCGACCTTCTGGTCGGCGCGCGCGCCCATGGCGCGGTCGTTGCGACTTATCCTGCGGATGCTCGTCAC
TGTCTGCGTGTTGACGCTGCTGCTCGGCGTCGCGGCTTATTGGCGCGGCGGGGCGGCGGCGGGTCCGTGGATGGGATCGA
CGCTGACGTTCGCCGCGATGGTGGTGGCGACCGGTGGGTTGGTCATCGTCGATGCGGGGGTGCGTCAGGGCAGCGCTGGG
CTGAGGATGCCGGTGATGGCGGTCGCGGGCGGCTTTGCAATGCTCTGGGCTTACCAGCTCAACGTCCAGCTGATCGGCGC
GCTGACAGGCACGCGCGCATCGACGCTGATCGCGCTGCTTCCCGCGGTCGCGCTGCTGGCGCTGCCAACCTATGTCGTGG
CGGCGATGGACATCGGGCGCGAGCGGATGCGGTTGTCACGTCCCGCCGCGACACGCGCGCTGACCCTGCTGGGCGCGGCC
TGCTACCTGATCCTGATCGCGCTGACCGTTGCCGCCGCCCGCGCCATGGGCGGCGATTATGCGGAACTGGCGCAGGCCAT
CTCGCTGCTCGCGCTGTCGGGCGCGGCAGTGCTGATGCTTGCCTCGGCGCGGTCGCGCGCGTGGCTGTCGGTGATGATCT
CGAAGCATTTTTTCGAGCATCGTTATGATTATCGCGCCGAATGGATGCGCTTCACCGCGACGCTGGCGCAGGGCGCCAAA
GGCGACGGCGGTGAGGATGACCGCAATCTTTACCGCCGCGTCGCCAAGGCGCTCGCCGAACTGACGGGCAGCCCCGGCGC
GCTGCTGATGACGCCAGCGGCCGCGGGCGGTTTTCGCATCGCCGAACAATGGTGCTGGCCGGGCGACGTGGCGGACGATG
CGACGCTGTCGCTGCGGTCGGCCTTCATGCTTCAGGAAACGCAGCATATCGTCGAACTCGATGCCGAAAGGCGCGGGCAG
GGTGGCCAGGATCTGGCCATCCCACAATGGTTGCTCGCCGACACGCGCGCGTGGGTGGTCGTGCCTGTGCTGCATTTCCA
GCGGATGATCGCGATCGCGGTGCTGCACCGTCCCGCGGTGTCGCGCGCGCTCGACTGGGAGGATCTCGACGTGCTGCGTA
TCGCGGGGCAGCAGGCGGCCAGCTATATCGCCGAATCGCAGAGCCAGCGGGCGCTGTCCGAGGCGCGGCGCTTCGACGAG
TTCAACCGCCGCTTTGCCTTCATCATGCACGACATCAAGAATCTGGCGAGCCAGCTCGGCCTGTTGGCGCGCAACGCCGA
GCGCCACGCCGACAATCCGGCGTTCCGCGCCGACATGACGCAGACGCTGAAGATTTCGGCGGGGCGGCTGTCCGATCTGC
TCGTCCGCCTGTCGCCGCGCGAGCATGCACCGACGGCCGATCCGGGGTGGGTTCCGGTCGAACCGATACTGAAAGACATC
GCCGCCGAAGTACGGCCGCGCCGCGAGCTGTTCATCGGGTGCGAGGCCGGCCTTGCCGCGTGGGCCGATGCGGGCTCGGT
GCGACGGATCGTCGGGCATCTCGTCGCCAATGCGATCGAGGCCTCTGCCGCGGGAATGCCGGTGCAGATCGTCGCGGTCG
CCGAACAGGGACGCGTGCGGATCGACGTGATCGACCAGGGATGCGGCATGACGCGCGAGTTCATTCGCGACGAGCTGTTC
AAGCCCTTTGTCTCGACCAAGGACAGCGGGTTCGGACTCGGGGCGTTCGAGGCGCTGCAGTTGGCTCAGGCGATGGGCGG
CGCGATCGAGGTGGCCAGCGAAGTCGGCGAAGGAAGCAATTTCACATTGTGGCTGCCGCTCGCCGACGCGTCCAGCGCCG
CGGTGGTTGACGCGCGGGCGATCAATGGGGGGCGGACATGA

Upstream 100 bases:

>100_bases
TATGACCTCTACTACGCCAAAAATTATTCGCCCTTCCTCGACCTTCTGATCCTGCTCCAGACCGTGCGCGTCGTGCTGTG
GCCCGAGGGAGCACGCTAGC

Downstream 100 bases:

>100_bases
ACGAAACGGCGGCAGCCCGTCGCAAACTGCTGGTGGTCGAGGATGATCCGGGGCTGCAGACGCAGCTCAAATGGGCCTAT
GAAGATTATCAGGTGTTCGT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MAAMDGLSQLLSGMALVGFAGAALWLLLRPRARMAALMPAPRLLALGAATTALWAAAMMRFTPGAPQVLVVQTLRDAAML
VWLGATFWSARAPMARSLRLILRMLVTVCVLTLLLGVAAYWRGGAAAGPWMGSTLTFAAMVVATGGLVIVDAGVRQGSAG
LRMPVMAVAGGFAMLWAYQLNVQLIGALTGTRASTLIALLPAVALLALPTYVVAAMDIGRERMRLSRPAATRALTLLGAA
CYLILIALTVAAARAMGGDYAELAQAISLLALSGAAVLMLASARSRAWLSVMISKHFFEHRYDYRAEWMRFTATLAQGAK
GDGGEDDRNLYRRVAKALAELTGSPGALLMTPAAAGGFRIAEQWCWPGDVADDATLSLRSAFMLQETQHIVELDAERRGQ
GGQDLAIPQWLLADTRAWVVVPVLHFQRMIAIAVLHRPAVSRALDWEDLDVLRIAGQQAASYIAESQSQRALSEARRFDE
FNRRFAFIMHDIKNLASQLGLLARNAERHADNPAFRADMTQTLKISAGRLSDLLVRLSPREHAPTADPGWVPVEPILKDI
AAEVRPRRELFIGCEAGLAAWADAGSVRRIVGHLVANAIEASAAGMPVQIVAVAEQGRVRIDVIDQGCGMTREFIRDELF
KPFVSTKDSGFGLGAFEALQLAQAMGGAIEVASEVGEGSNFTLWLPLADASSAAVVDARAINGGRT

Sequences:

>Translated_706_residues
MAAMDGLSQLLSGMALVGFAGAALWLLLRPRARMAALMPAPRLLALGAATTALWAAAMMRFTPGAPQVLVVQTLRDAAML
VWLGATFWSARAPMARSLRLILRMLVTVCVLTLLLGVAAYWRGGAAAGPWMGSTLTFAAMVVATGGLVIVDAGVRQGSAG
LRMPVMAVAGGFAMLWAYQLNVQLIGALTGTRASTLIALLPAVALLALPTYVVAAMDIGRERMRLSRPAATRALTLLGAA
CYLILIALTVAAARAMGGDYAELAQAISLLALSGAAVLMLASARSRAWLSVMISKHFFEHRYDYRAEWMRFTATLAQGAK
GDGGEDDRNLYRRVAKALAELTGSPGALLMTPAAAGGFRIAEQWCWPGDVADDATLSLRSAFMLQETQHIVELDAERRGQ
GGQDLAIPQWLLADTRAWVVVPVLHFQRMIAIAVLHRPAVSRALDWEDLDVLRIAGQQAASYIAESQSQRALSEARRFDE
FNRRFAFIMHDIKNLASQLGLLARNAERHADNPAFRADMTQTLKISAGRLSDLLVRLSPREHAPTADPGWVPVEPILKDI
AAEVRPRRELFIGCEAGLAAWADAGSVRRIVGHLVANAIEASAAGMPVQIVAVAEQGRVRIDVIDQGCGMTREFIRDELF
KPFVSTKDSGFGLGAFEALQLAQAMGGAIEVASEVGEGSNFTLWLPLADASSAAVVDARAINGGRT
>Mature_705_residues
AAMDGLSQLLSGMALVGFAGAALWLLLRPRARMAALMPAPRLLALGAATTALWAAAMMRFTPGAPQVLVVQTLRDAAMLV
WLGATFWSARAPMARSLRLILRMLVTVCVLTLLLGVAAYWRGGAAAGPWMGSTLTFAAMVVATGGLVIVDAGVRQGSAGL
RMPVMAVAGGFAMLWAYQLNVQLIGALTGTRASTLIALLPAVALLALPTYVVAAMDIGRERMRLSRPAATRALTLLGAAC
YLILIALTVAAARAMGGDYAELAQAISLLALSGAAVLMLASARSRAWLSVMISKHFFEHRYDYRAEWMRFTATLAQGAKG
DGGEDDRNLYRRVAKALAELTGSPGALLMTPAAAGGFRIAEQWCWPGDVADDATLSLRSAFMLQETQHIVELDAERRGQG
GQDLAIPQWLLADTRAWVVVPVLHFQRMIAIAVLHRPAVSRALDWEDLDVLRIAGQQAASYIAESQSQRALSEARRFDEF
NRRFAFIMHDIKNLASQLGLLARNAERHADNPAFRADMTQTLKISAGRLSDLLVRLSPREHAPTADPGWVPVEPILKDIA
AEVRPRRELFIGCEAGLAAWADAGSVRRIVGHLVANAIEASAAGMPVQIVAVAEQGRVRIDVIDQGCGMTREFIRDELFK
PFVSTKDSGFGLGAFEALQLAQAMGGAIEVASEVGEGSNFTLWLPLADASSAAVVDARAINGGRT

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 75462; Mature: 75331

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMDGLSQLLSGMALVGFAGAALWLLLRPRARMAALMPAPRLLALGAATTALWAAAMMR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FTPGAPQVLVVQTLRDAAMLVWLGATFWSARAPMARSLRLILRMLVTVCVLTLLLGVAAY
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRGGAAAGPWMGSTLTFAAMVVATGGLVIVDAGVRQGSAGLRMPVMAVAGGFAMLWAYQL
HCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
NVQLIGALTGTRASTLIALLPAVALLALPTYVVAAMDIGRERMRLSRPAATRALTLLGAA
CEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHH
CYLILIALTVAAARAMGGDYAELAQAISLLALSGAAVLMLASARSRAWLSVMISKHFFEH
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHH
RYDYRAEWMRFTATLAQGAKGDGGEDDRNLYRRVAKALAELTGSPGALLMTPAAAGGFRI
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
AEQWCWPGDVADDATLSLRSAFMLQETQHIVELDAERRGQGGQDLAIPQWLLADTRAWVV
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCCCEE
VPVLHFQRMIAIAVLHRPAVSRALDWEDLDVLRIAGQQAASYIAESQSQRALSEARRFDE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNRRFAFIMHDIKNLASQLGLLARNAERHADNPAFRADMTQTLKISAGRLSDLLVRLSPR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHCCHHHHEECHHHHHHHHHHCCCC
EHAPTADPGWVPVEPILKDIAAEVRPRRELFIGCEAGLAAWADAGSVRRIVGHLVANAIE
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHEEEECCCCHHHHHCCCHHHHHHHHHHHHHHH
ASAAGMPVQIVAVAEQGRVRIDVIDQGCGMTREFIRDELFKPFVSTKDSGFGLGAFEALQ
HHCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LAQAMGGAIEVASEVGEGSNFTLWLPLADASSAAVVDARAINGGRT
HHHHHCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
AAMDGLSQLLSGMALVGFAGAALWLLLRPRARMAALMPAPRLLALGAATTALWAAAMMR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FTPGAPQVLVVQTLRDAAMLVWLGATFWSARAPMARSLRLILRMLVTVCVLTLLLGVAAY
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRGGAAAGPWMGSTLTFAAMVVATGGLVIVDAGVRQGSAGLRMPVMAVAGGFAMLWAYQL
HCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
NVQLIGALTGTRASTLIALLPAVALLALPTYVVAAMDIGRERMRLSRPAATRALTLLGAA
CEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHH
CYLILIALTVAAARAMGGDYAELAQAISLLALSGAAVLMLASARSRAWLSVMISKHFFEH
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHH
RYDYRAEWMRFTATLAQGAKGDGGEDDRNLYRRVAKALAELTGSPGALLMTPAAAGGFRI
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
AEQWCWPGDVADDATLSLRSAFMLQETQHIVELDAERRGQGGQDLAIPQWLLADTRAWVV
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCCCEE
VPVLHFQRMIAIAVLHRPAVSRALDWEDLDVLRIAGQQAASYIAESQSQRALSEARRFDE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNRRFAFIMHDIKNLASQLGLLARNAERHADNPAFRADMTQTLKISAGRLSDLLVRLSPR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHCCHHHHEECHHHHHHHHHHCCCC
EHAPTADPGWVPVEPILKDIAAEVRPRRELFIGCEAGLAAWADAGSVRRIVGHLVANAIE
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHEEEECCCCHHHHHCCCHHHHHHHHHHHHHHH
ASAAGMPVQIVAVAEQGRVRIDVIDQGCGMTREFIRDELFKPFVSTKDSGFGLGAFEALQ
HHCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LAQAMGGAIEVASEVGEGSNFTLWLPLADASSAAVVDARAINGGRT
HHHHHCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]