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The map label for this gene is envZ [H]

Identifier: 103486251

GI number: 103486251

Start: 767085

End: 768377

Strand: Direct

Name: envZ [H]

Synonym: Sala_0759

Alternate gene names: 103486251

Gene position: 767085-768377 (Clockwise)

Preceding gene: 103486250

Following gene: 103486258

Centisome position: 22.93

GC content: 71.08

Gene sequence:

>1293_bases
GTGATGCTGTTCGTCGCGCAGGCGGTCAATTTTGCGCTGCTCGTGCGCGGACAAAAGCAACAGATGCTCGCGCATGGCGG
CGGCATGGCGGTGGCGCGGATCATCGATGCGATCGACCGCCACGAAAGCGGCCGGATCGCGGCGATGCCCGATCGCCGCC
AGCGTTCTGGCCGGGCGCGCATCCCGAAACTCTGGGTCGGCGCCAGCGCGCCGCCGGTGCCCGAGCGCGCGGTCGCGCTG
CCGGCGATGGCGGACTATGTGCACGACCTGCTCGCCGAGGCCGAGGTCGATGCCGCAGCCGTCACCGCGTGGGCCTTGCC
GCAGCGGCCGCGGCTGGGGCGCACACGGCTGCCCGGTCGCACCGTGCTCGTCGTCGCCGAGGTGGATGGGCGCTTCTATG
GCGTACGCACCCGCGTCGCGCCCGACGGTCGCCGCTTGCAGGGCTTCCTCGTCTGGCAGACGCTGTCGCTCTACCTCTTG
CTGCTGATCCCGATCCTCGTGATCGCGTGGCGCGTCGCCGCGCCGCTCCGCGACCTGACGCGCGCGGCGCGCGCCAGCCC
TGCGCTGCACGAGGCGGTGCCGCTCGCGGAGGCGGGACCGTCGGACGTGCGCGACCTGATTGCGGCTTTCAACGCCTATC
GCGCGCGCATCGCGGCGATGCTGGCCGACAAGGACCGGATGCTCGGCGCGGTCGGGCATGACTTGCGCACCCCGCTTGCC
AGCCTGCGCGTCCGCGTCGAGCAGGTCGAGGATGATCGGCTGCGCGACAAGATGATCGCCAGCATCGACGAAATGACCGC
GATGCTGACCGATATATTGGCGCTGGCGCGGTCGGGCGCGGGGACCGAGGCGGTCGGGGCGCTCGCACTGGACGAACTCG
TCGGCGAAATCATTGCCGACTATCGCGAGCGCGGCAAGGATGTCGCGGCGGGGGCGTTGGCCCCGGCGACGGTGCACGCG
CGGCCGATGCTGCTGAAGCGCGCGGTGCGCAACCTCGTCGACAATGCCGTCGCCTATGGCGTGCGCGCGCGGCTGTCGGT
GATGGTAGAGGGCGGCAAGGCGCGGATTATCGTGTCGGACGACGGCCCCGGCCTGACCGACGAGCAGATCCGTACGCTGG
TCGAACCCTTCGCGCGTGGCGAGTTGTCGCGCAACCGTGCGACTGGCGGTGCTGGCCTGGGCCTGTCGATCGCCCGCGAA
ATTGCGGAGGGCGAGGGAGGAACGCTGACACTTGCGAACCGCGCGGGCGGCGGGCTCGATGCGGTGATCGCGTTGCCGGT
TCAGGGGCGGTGA

Upstream 100 bases:

>100_bases
GTTATACGCTCGCGTGCGAGGTCAAGCGACTGGGCCCCGCTGCGTGAGGCTGCGACTTTGGCCCCGCAGCCTGATCGGGC
AGCTGGTCTTCGCGGTCGCG

Downstream 100 bases:

>100_bases
GCCGCCATAGCCCGCGCCCCTGAAGGGAAGAGAACCACTTTGACCGCCTTTGAACCTTCCCACTCGATGCAAATGGCGTC
GCAAAGCCGGACGTCCCCAA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MMLFVAQAVNFALLVRGQKQQMLAHGGGMAVARIIDAIDRHESGRIAAMPDRRQRSGRARIPKLWVGASAPPVPERAVAL
PAMADYVHDLLAEAEVDAAAVTAWALPQRPRLGRTRLPGRTVLVVAEVDGRFYGVRTRVAPDGRRLQGFLVWQTLSLYLL
LLIPILVIAWRVAAPLRDLTRAARASPALHEAVPLAEAGPSDVRDLIAAFNAYRARIAAMLADKDRMLGAVGHDLRTPLA
SLRVRVEQVEDDRLRDKMIASIDEMTAMLTDILALARSGAGTEAVGALALDELVGEIIADYRERGKDVAAGALAPATVHA
RPMLLKRAVRNLVDNAVAYGVRARLSVMVEGGKARIIVSDDGPGLTDEQIRTLVEPFARGELSRNRATGGAGLGLSIARE
IAEGEGGTLTLANRAGGGLDAVIALPVQGR

Sequences:

>Translated_430_residues
MMLFVAQAVNFALLVRGQKQQMLAHGGGMAVARIIDAIDRHESGRIAAMPDRRQRSGRARIPKLWVGASAPPVPERAVAL
PAMADYVHDLLAEAEVDAAAVTAWALPQRPRLGRTRLPGRTVLVVAEVDGRFYGVRTRVAPDGRRLQGFLVWQTLSLYLL
LLIPILVIAWRVAAPLRDLTRAARASPALHEAVPLAEAGPSDVRDLIAAFNAYRARIAAMLADKDRMLGAVGHDLRTPLA
SLRVRVEQVEDDRLRDKMIASIDEMTAMLTDILALARSGAGTEAVGALALDELVGEIIADYRERGKDVAAGALAPATVHA
RPMLLKRAVRNLVDNAVAYGVRARLSVMVEGGKARIIVSDDGPGLTDEQIRTLVEPFARGELSRNRATGGAGLGLSIARE
IAEGEGGTLTLANRAGGGLDAVIALPVQGR
>Mature_430_residues
MMLFVAQAVNFALLVRGQKQQMLAHGGGMAVARIIDAIDRHESGRIAAMPDRRQRSGRARIPKLWVGASAPPVPERAVAL
PAMADYVHDLLAEAEVDAAAVTAWALPQRPRLGRTRLPGRTVLVVAEVDGRFYGVRTRVAPDGRRLQGFLVWQTLSLYLL
LLIPILVIAWRVAAPLRDLTRAARASPALHEAVPLAEAGPSDVRDLIAAFNAYRARIAAMLADKDRMLGAVGHDLRTPLA
SLRVRVEQVEDDRLRDKMIASIDEMTAMLTDILALARSGAGTEAVGALALDELVGEIIADYRERGKDVAAGALAPATVHA
RPMLLKRAVRNLVDNAVAYGVRARLSVMVEGGKARIIVSDDGPGLTDEQIRTLVEPFARGELSRNRATGGAGLGLSIARE
IAEGEGGTLTLANRAGGGLDAVIALPVQGR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=258, Percent_Identity=34.1085271317829, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1787894, Length=251, Percent_Identity=31.0756972111554, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=27.710843373494, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87082128, Length=317, Percent_Identity=26.1829652996845, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789403, Length=281, Percent_Identity=31.6725978647687, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=29.3103448275862, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=32.8828828828829, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790551, Length=262, Percent_Identity=30.5343511450382, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786783, Length=327, Percent_Identity=22.9357798165138, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=301, Percent_Identity=26.9102990033223, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=218, Percent_Identity=24.3119266055046, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=27.0642201834862, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45947; Mature: 45947

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLFVAQAVNFALLVRGQKQQMLAHGGGMAVARIIDAIDRHESGRIAAMPDRRQRSGRAR
CEEEEEHHHCCCEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHCCCCC
IPKLWVGASAPPVPERAVALPAMADYVHDLLAEAEVDAAAVTAWALPQRPRLGRTRLPGR
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCC
TVLVVAEVDGRFYGVRTRVAPDGRRLQGFLVWQTLSLYLLLLIPILVIAWRVAAPLRDLT
EEEEEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAARASPALHEAVPLAEAGPSDVRDLIAAFNAYRARIAAMLADKDRMLGAVGHDLRTPLA
HHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SLRVRVEQVEDDRLRDKMIASIDEMTAMLTDILALARSGAGTEAVGALALDELVGEIIAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
YRERGKDVAAGALAPATVHARPMLLKRAVRNLVDNAVAYGVRARLSVMVEGGKARIIVSD
HHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEEEEEEEC
DGPGLTDEQIRTLVEPFARGELSRNRATGGAGLGLSIAREIAEGEGGTLTLANRAGGGLD
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCE
AVIALPVQGR
EEEEECCCCC
>Mature Secondary Structure
MMLFVAQAVNFALLVRGQKQQMLAHGGGMAVARIIDAIDRHESGRIAAMPDRRQRSGRAR
CEEEEEHHHCCCEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHCCCCC
IPKLWVGASAPPVPERAVALPAMADYVHDLLAEAEVDAAAVTAWALPQRPRLGRTRLPGR
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCC
TVLVVAEVDGRFYGVRTRVAPDGRRLQGFLVWQTLSLYLLLLIPILVIAWRVAAPLRDLT
EEEEEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAARASPALHEAVPLAEAGPSDVRDLIAAFNAYRARIAAMLADKDRMLGAVGHDLRTPLA
HHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SLRVRVEQVEDDRLRDKMIASIDEMTAMLTDILALARSGAGTEAVGALALDELVGEIIAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
YRERGKDVAAGALAPATVHARPMLLKRAVRNLVDNAVAYGVRARLSVMVEGGKARIIVSD
HHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEEEEEEEC
DGPGLTDEQIRTLVEPFARGELSRNRATGGAGLGLSIAREIAEGEGGTLTLANRAGGGLD
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCE
AVIALPVQGR
EEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]