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The map label for this gene is serS

Identifier: 103486215

GI number: 103486215

Start: 728289

End: 729569

Strand: Reverse

Name: serS

Synonym: Sala_0722

Alternate gene names: 103486215

Gene position: 729569-728289 (Counterclockwise)

Preceding gene: 103486216

Following gene: 103486214

Centisome position: 21.81

GC content: 67.29

Gene sequence:

>1281_bases
ATGCACGACATCCGCCTGATCCGCGACAACCCGCACGCCTTCGACGCCGGCCTCGCGCGCCGCGGCCTTGCGCCGCTGTC
CGCCGAAATCCTCGCCGCCGATGCCGAACTTCGCGCGCTGCAAACCGACATCCAGGCCGCACTCGCGCGCCGCAACGAAG
CCTCGAAACTCATCGGGCAGGCGATGGCCGCCGGCGACAAGGACAAGGCGGAGGCGCTGAAGGCCGAGGTCGCCGCGCTG
AAGGCCGCCCTCCCGGCCAGGGAAGAGGCCGAGCGCGCGCAGCTCGCGGCGCTCCACGACCGCCTCGCCGCGCTCCCCAA
CCTCCCCGCCGACGACGTGCCCGATGGCGAGGACGAGGCGGGCAATGTCGAACTGTCGCGCTGGGGCACGCCGCGCAGCT
TCGATTTCACGCCGCTGGAACATGCCGATTTCGCCCCCGCGCTCGGTCTCGATTTCGAAACGGCGGCGAAGATGTCGGGC
GCACGCTTCGCCTTTCTCAAAGGCCCGATGGCGCGGCTCGAACGCGCGCTCGGCCAGTTCATGCTCGACAGGCAGACGAT
CGAGGCGGGATACACCGAATGTGCGACGCCGCTGCTCGTCCGCGACGACGCCGCTTTCGGAACGACGCAGCTTCCCAAGT
TCCGCGAGGATCTGTTCCAGACCACCGACGGCCTCTGGCTCATCTCGACCTCCGAAATGAGCCTCACAAATGCGGTACGC
GAGCAGATATTGGCCGAGGCCGATCTGCCGATCCGCATGACCGCGCTCACCCCCTGCTTCCGTTCCGAAGCGGGGTCGGC
GGGGCGCGACACGCGCGGCTATATCCGCCAGCACCAGTTCTGGAAGGTCGAGCTGGTCTCGATCACCCGCCCCGAAGACA
GCGACGCCGAACTCGAACGCAAGACGCGCGCCGCCGAGAGCATCCTCGAAGCGCTCGAATTGCCCTATCGCAAGATGCTG
CTCTGCGCCGGCGACATGGGCTTTGCCGCACGCAAGACCTACGATCTCGAAGTCTGGCTGCCCGGCCAGAACGCCTATCG
CGAGATTTCGAGCTGTTCGAACTGCGGCGATTTCCAGGCACGCCGCATGAACGCGCGCTTCCGGCGAGAGGGCGGCAAGG
GCAATGAGTTCGTCCACACATTGAACGGCTCGGGTCTTGCGGTCGGGCGCACGCTCGTCGCGATCCTCGAAAATTACCAG
CAGGCCGACGGCAGCGTCGACATTCCGGCGGCGCTGCTGCCCTATATGGGCGGGATCACCCGGCTGACGCCCCTGGGTTG
A

Upstream 100 bases:

>100_bases
CACCGAACTGAGGGCCGCTCTTCGGGGCGGCCCTTTTTTACGCCCGCGACGCCGGTGCAACGGGGTTGCGCGCGCCCGGC
GGTAACGCCATAGCGCGCTC

Downstream 100 bases:

>100_bases
CAAGGTTAAACTGACTCCACTTTCCCGTTCGTGTCGAGCGAAGTCGAGACACCCAACGGCCTTGCGCCATGCCGATGGGC
ATCTCGACTTCGCTCAATGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHDIRLIRDNPHAFDAGLARRGLAPLSAEILAADAELRALQTDIQAALARRNEASKLIGQAMAAGDKDKAEALKAEVAAL
KAALPAREEAERAQLAALHDRLAALPNLPADDVPDGEDEAGNVELSRWGTPRSFDFTPLEHADFAPALGLDFETAAKMSG
ARFAFLKGPMARLERALGQFMLDRQTIEAGYTECATPLLVRDDAAFGTTQLPKFREDLFQTTDGLWLISTSEMSLTNAVR
EQILAEADLPIRMTALTPCFRSEAGSAGRDTRGYIRQHQFWKVELVSITRPEDSDAELERKTRAAESILEALELPYRKML
LCAGDMGFAARKTYDLEVWLPGQNAYREISSCSNCGDFQARRMNARFRREGGKGNEFVHTLNGSGLAVGRTLVAILENYQ
QADGSVDIPAALLPYMGGITRLTPLG

Sequences:

>Translated_426_residues
MHDIRLIRDNPHAFDAGLARRGLAPLSAEILAADAELRALQTDIQAALARRNEASKLIGQAMAAGDKDKAEALKAEVAAL
KAALPAREEAERAQLAALHDRLAALPNLPADDVPDGEDEAGNVELSRWGTPRSFDFTPLEHADFAPALGLDFETAAKMSG
ARFAFLKGPMARLERALGQFMLDRQTIEAGYTECATPLLVRDDAAFGTTQLPKFREDLFQTTDGLWLISTSEMSLTNAVR
EQILAEADLPIRMTALTPCFRSEAGSAGRDTRGYIRQHQFWKVELVSITRPEDSDAELERKTRAAESILEALELPYRKML
LCAGDMGFAARKTYDLEVWLPGQNAYREISSCSNCGDFQARRMNARFRREGGKGNEFVHTLNGSGLAVGRTLVAILENYQ
QADGSVDIPAALLPYMGGITRLTPLG
>Mature_426_residues
MHDIRLIRDNPHAFDAGLARRGLAPLSAEILAADAELRALQTDIQAALARRNEASKLIGQAMAAGDKDKAEALKAEVAAL
KAALPAREEAERAQLAALHDRLAALPNLPADDVPDGEDEAGNVELSRWGTPRSFDFTPLEHADFAPALGLDFETAAKMSG
ARFAFLKGPMARLERALGQFMLDRQTIEAGYTECATPLLVRDDAAFGTTQLPKFREDLFQTTDGLWLISTSEMSLTNAVR
EQILAEADLPIRMTALTPCFRSEAGSAGRDTRGYIRQHQFWKVELVSITRPEDSDAELERKTRAAESILEALELPYRKML
LCAGDMGFAARKTYDLEVWLPGQNAYREISSCSNCGDFQARRMNARFRREGGKGNEFVHTLNGSGLAVGRTLVAILENYQ
QADGSVDIPAALLPYMGGITRLTPLG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=445, Percent_Identity=33.7078651685393, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI8923421, Length=407, Percent_Identity=30.7125307125307, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI225579074, Length=404, Percent_Identity=30.1980198019802, Blast_Score=169, Evalue=3e-42,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=54.4392523364486, Blast_Score=438, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17539260, Length=340, Percent_Identity=34.7058823529412, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=307, Percent_Identity=29.6416938110749, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=427, Percent_Identity=30.9133489461358, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6321799, Length=411, Percent_Identity=30.9002433090024, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24581334, Length=293, Percent_Identity=36.8600682593857, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17737985, Length=355, Percent_Identity=32.6760563380282, Blast_Score=158, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SPHAL (Q1GV79)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615776.1
- ProteinModelPortal:   Q1GV79
- SMR:   Q1GV79
- GeneID:   4081342
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0722
- NMPDR:   fig|317655.9.peg.670
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   SALA317655:SALA_0722-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46589; Mature: 46589

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRLIRDNPHAFDAGLARRGLAPLSAEILAADAELRALQTDIQAALARRNEASKLIGQ
CCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAAGDKDKAEALKAEVAALKAALPAREEAERAQLAALHDRLAALPNLPADDVPDGEDEA
HHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GNVELSRWGTPRSFDFTPLEHADFAPALGLDFETAAKMSGARFAFLKGPMARLERALGQF
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHH
MLDRQTIEAGYTECATPLLVRDDAAFGTTQLPKFREDLFQTTDGLWLISTSEMSLTNAVR
HHHHHHHHHCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
EQILAEADLPIRMTALTPCFRSEAGSAGRDTRGYIRQHQFWKVELVSITRPEDSDAELER
HHHHHHCCCCEEEEHHCHHHHHCCCCCCCCHHHHHHHCCEEEEEEEEEECCCCCHHHHHH
KTRAAESILEALELPYRKMLLCAGDMGFAARKTYDLEVWLPGQNAYREISSCSNCGDFQA
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCHHH
RRMNARFRREGGKGNEFVHTLNGSGLAVGRTLVAILENYQQADGSVDIPAALLPYMGGIT
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
RLTPLG
CCCCCC
>Mature Secondary Structure
MHDIRLIRDNPHAFDAGLARRGLAPLSAEILAADAELRALQTDIQAALARRNEASKLIGQ
CCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAAGDKDKAEALKAEVAALKAALPAREEAERAQLAALHDRLAALPNLPADDVPDGEDEA
HHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GNVELSRWGTPRSFDFTPLEHADFAPALGLDFETAAKMSGARFAFLKGPMARLERALGQF
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHH
MLDRQTIEAGYTECATPLLVRDDAAFGTTQLPKFREDLFQTTDGLWLISTSEMSLTNAVR
HHHHHHHHHCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
EQILAEADLPIRMTALTPCFRSEAGSAGRDTRGYIRQHQFWKVELVSITRPEDSDAELER
HHHHHHCCCCEEEEHHCHHHHHCCCCCCCCHHHHHHHCCEEEEEEEEEECCCCCHHHHHH
KTRAAESILEALELPYRKMLLCAGDMGFAARKTYDLEVWLPGQNAYREISSCSNCGDFQA
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCHHH
RRMNARFRREGGKGNEFVHTLNGSGLAVGRTLVAILENYQQADGSVDIPAALLPYMGGIT
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
RLTPLG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA