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The map label for this gene is gloB [H]

Identifier: 103486177

GI number: 103486177

Start: 693889

End: 694629

Strand: Reverse

Name: gloB [H]

Synonym: Sala_0684

Alternate gene names: 103486177

Gene position: 694629-693889 (Counterclockwise)

Preceding gene: 103486178

Following gene: 103486176

Centisome position: 20.77

GC content: 68.15

Gene sequence:

>741_bases
GTGGCTGCACTCGAAATCGTCCGGATCCCGGTCCTCAGCGACAATTATGTCTGGCTGGTCCACGAGCCCGCCAGCGGCGC
GACGATGGTGGTCGACCCGGCGGTCGCCGATCCGGTGCTCGACGCGGCGAAGGCGCGCGGCTGGGCGATCACCGACATCT
GGAACACCCACTGGCACCCTGACCATACGGGCGGCAATGCCGCGATCAAGGAAGCGGCCAAGGCATGGGGCGGCTGCACG
ATCACCGGCCCCGCGGCCGAACATGAACGCATCCCGACACTCGACGTGCTGGTAAAGGGCGGCGACACGGTGCGGCTGGG
CGACCATGTCGCGGATGTCTGGGACGTCCCCGCGCACACCGCGGGCCATATCGCCTATCATTTTGCGGATGACGCCGCGA
TCTTCGTCGGCGACACGATGTTCGCCATGGGGTGCGGCCGCCTGTTCGAGGGGACGGCCGAGCAGATGTTCGCCAATATG
CAGAAGCTCAGGGCGCTCGACGATGCAACGCGCGTTTATTGTGCGCACGAATATACGCTGTCCAACGCGCGTTTCGCGAT
CACCGTCGATCCGGCCAATGAGGCGCTGGCGGCGCGGCTTGCCGCGGTCGAGGCTGCCCGCGCGGCGGGCGAGGCGACGG
TGCCGACGAGCATCGGCGCCGAGCGCGCGACAAACCCCTTTTTCCGCGCGCCCGACGCCGCGGAACTCGCGCGCATCCGC
GCGCTCAAGGATGCGGCGTGA

Upstream 100 bases:

>100_bases
GGAAGGCGAGACTTTCCGCGGCGACTGTGGCAGAGTGGCGCACCAAGGTCCGCCGGCATCCACTCCGTCTTGTGGGTGCA
TGAGCTGCAAAGGAGGCATG

Downstream 100 bases:

>100_bases
TACGCGGGCGGCTTCAGCACCGGTTCATCGGCCACGGCTATTCTGGCTGGTCGCAAGGAGCAATGTCATGGCCAAGCTGA
ATCCGATGGCGGTCGCGCTG

Product: hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MAALEIVRIPVLSDNYVWLVHEPASGATMVVDPAVADPVLDAAKARGWAITDIWNTHWHPDHTGGNAAIKEAAKAWGGCT
ITGPAAEHERIPTLDVLVKGGDTVRLGDHVADVWDVPAHTAGHIAYHFADDAAIFVGDTMFAMGCGRLFEGTAEQMFANM
QKLRALDDATRVYCAHEYTLSNARFAITVDPANEALAARLAAVEAARAAGEATVPTSIGAERATNPFFRAPDAAELARIR
ALKDAA

Sequences:

>Translated_246_residues
MAALEIVRIPVLSDNYVWLVHEPASGATMVVDPAVADPVLDAAKARGWAITDIWNTHWHPDHTGGNAAIKEAAKAWGGCT
ITGPAAEHERIPTLDVLVKGGDTVRLGDHVADVWDVPAHTAGHIAYHFADDAAIFVGDTMFAMGCGRLFEGTAEQMFANM
QKLRALDDATRVYCAHEYTLSNARFAITVDPANEALAARLAAVEAARAAGEATVPTSIGAERATNPFFRAPDAAELARIR
ALKDAA
>Mature_245_residues
AALEIVRIPVLSDNYVWLVHEPASGATMVVDPAVADPVLDAAKARGWAITDIWNTHWHPDHTGGNAAIKEAAKAWGGCTI
TGPAAEHERIPTLDVLVKGGDTVRLGDHVADVWDVPAHTAGHIAYHFADDAAIFVGDTMFAMGCGRLFEGTAEQMFANMQ
KLRALDDATRVYCAHEYTLSNARFAITVDPANEALAARLAAVEAARAAGEATVPTSIGAERATNPFFRAPDAAELARIRA
LKDAA

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI94538322, Length=237, Percent_Identity=35.4430379746835, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI94538320, Length=235, Percent_Identity=35.7446808510638, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI14150041, Length=231, Percent_Identity=35.9307359307359, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI116642887, Length=232, Percent_Identity=32.3275862068966, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI21703352, Length=232, Percent_Identity=32.3275862068966, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI46361987, Length=207, Percent_Identity=35.7487922705314, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI1786406, Length=229, Percent_Identity=39.7379912663755, Blast_Score=161, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17536925, Length=235, Percent_Identity=34.468085106383, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320478, Length=230, Percent_Identity=30, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324614, Length=234, Percent_Identity=28.6324786324786, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356335, Length=244, Percent_Identity=36.4754098360656, Blast_Score=170, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24667711, Length=244, Percent_Identity=36.4754098360656, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24667703, Length=243, Percent_Identity=36.6255144032922, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI221330176, Length=171, Percent_Identity=30.4093567251462, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 26147; Mature: 26015

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALEIVRIPVLSDNYVWLVHEPASGATMVVDPAVADPVLDAAKARGWAITDIWNTHWHP
CCCEEEEEEEEECCCEEEEEECCCCCCEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCC
DHTGGNAAIKEAAKAWGGCTITGPAAEHERIPTLDVLVKGGDTVRLGDHVADVWDVPAHT
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEECCCEEEECCHHHHHHCCCCCC
AGHIAYHFADDAAIFVGDTMFAMGCGRLFEGTAEQMFANMQKLRALDDATRVYCAHEYTL
CCEEEEEECCCEEEEECCHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEE
SNARFAITVDPANEALAARLAAVEAARAAGEATVPTSIGAERATNPFFRAPDAAELARIR
CCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHH
ALKDAA
HHHCCC
>Mature Secondary Structure 
AALEIVRIPVLSDNYVWLVHEPASGATMVVDPAVADPVLDAAKARGWAITDIWNTHWHP
CCEEEEEEEEECCCEEEEEECCCCCCEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCC
DHTGGNAAIKEAAKAWGGCTITGPAAEHERIPTLDVLVKGGDTVRLGDHVADVWDVPAHT
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEECCCEEEECCHHHHHHCCCCCC
AGHIAYHFADDAAIFVGDTMFAMGCGRLFEGTAEQMFANMQKLRALDDATRVYCAHEYTL
CCEEEEEECCCEEEEECCHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEE
SNARFAITVDPANEALAARLAAVEAARAAGEATVPTSIGAERATNPFFRAPDAAELARIR
CCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHH
ALKDAA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA