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The map label for this gene is trxC [H]

Identifier: 103485899

GI number: 103485899

Start: 414851

End: 415291

Strand: Reverse

Name: trxC [H]

Synonym: Sala_0405

Alternate gene names: 103485899

Gene position: 415291-414851 (Counterclockwise)

Preceding gene: 103485900

Following gene: 103485898

Centisome position: 12.41

GC content: 59.18

Gene sequence:

>441_bases
ATGGAAGCCGACAAGATCAAGGTAGTTTGCCCACATTGTGATGCGGTCAACGCTATCCCGCCTGATCGGCCAGCCCAGGC
CGCAAAATGCGGCAAATGCCACAAGGCGCTGTTCAATGGTTCGCCCGTCGACCTGCTGGGCCAGAGGTTCGATCGCCATA
TCACACGATCCGACATACCTGTCGTTGTGGATTTCTGGGCGACGTGGTGCGGTCCCTGCCGCGCCATGGCTCCATCATTT
GCCCAGGTCACGATTGCAATCGAACCGCGCGCCAGGTTCGCAAAGGTCGATATCGACAAGGCTCCCGAACTTGCCGCCCG
GTACGGCGTGCAGGGCGTCCCTGCCTTGTTAATATTCAAGAATGGACGGCTGGTCGATCAACGATCCGGTGCCTTACCCC
CCTCCGCGCTTCGCCAATGGGTGGAGGCACATATTGGCTGA

Upstream 100 bases:

>100_bases
CGACCGTCAAGGTCGACGAGGGCGAAGAAGGTCTCGTTTTCGTCATTCCATCCCAGATCTGAGCAGCGCGAGCGCACGAC
AAGCAAGGGAAGGGCGGCGA

Downstream 100 bases:

>100_bases
CCCGCATTTCCGCCCTGCATCCCAATTTCAGGTGATTTAGTTAATGGCAGATCCTTATACGATACTCGGCGTATCGCGCA
CCGCAGATCAGTCTGCGATC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MEADKIKVVCPHCDAVNAIPPDRPAQAAKCGKCHKALFNGSPVDLLGQRFDRHITRSDIPVVVDFWATWCGPCRAMAPSF
AQVTIAIEPRARFAKVDIDKAPELAARYGVQGVPALLIFKNGRLVDQRSGALPPSALRQWVEAHIG

Sequences:

>Translated_146_residues
MEADKIKVVCPHCDAVNAIPPDRPAQAAKCGKCHKALFNGSPVDLLGQRFDRHITRSDIPVVVDFWATWCGPCRAMAPSF
AQVTIAIEPRARFAKVDIDKAPELAARYGVQGVPALLIFKNGRLVDQRSGALPPSALRQWVEAHIG
>Mature_146_residues
MEADKIKVVCPHCDAVNAIPPDRPAQAAKCGKCHKALFNGSPVDLLGQRFDRHITRSDIPVVVDFWATWCGPCRAMAPSF
AQVTIAIEPRARFAKVDIDKAPELAARYGVQGVPALLIFKNGRLVDQRSGALPPSALRQWVEAHIG

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=137, Percent_Identity=32.1167883211679, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI224493972, Length=104, Percent_Identity=33.6538461538462, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI42794771, Length=105, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5031973, Length=81, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=42.1428571428571, Blast_Score=139, Evalue=9e-35,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=35.9223300970874, Blast_Score=95, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI212646193, Length=95, Percent_Identity=36.8421052631579, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=96, Percent_Identity=40.625, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=91, Percent_Identity=35.1648351648352, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=99, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=44.5652173913043, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=38.5416666666667, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17648013, Length=97, Percent_Identity=31.9587628865979, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=97, Percent_Identity=31.9587628865979, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24658597, Length=85, Percent_Identity=40, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15908; Mature: 15908

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEADKIKVVCPHCDAVNAIPPDRPAQAAKCGKCHKALFNGSPVDLLGQRFDRHITRSDIP
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
VVVDFWATWCGPCRAMAPSFAQVTIAIEPRARFAKVDIDKAPELAARYGVQGVPALLIFK
EEEEHHHHHHCHHHHCCCCCEEEEEEECCCCEEEECCCCCCHHHHHHCCCCCCCEEEEEE
NGRLVDQRSGALPPSALRQWVEAHIG
CCCEECCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEADKIKVVCPHCDAVNAIPPDRPAQAAKCGKCHKALFNGSPVDLLGQRFDRHITRSDIP
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
VVVDFWATWCGPCRAMAPSFAQVTIAIEPRARFAKVDIDKAPELAARYGVQGVPALLIFK
EEEEHHHHHHCHHHHCCCCCEEEEEEECCCCEEEECCCCCCHHHHHHCCCCCCCEEEEEE
NGRLVDQRSGALPPSALRQWVEAHIG
CCCEECCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]