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The map label for this gene is uvrB [H]

Identifier: 103485770

GI number: 103485770

Start: 272384

End: 274570

Strand: Reverse

Name: uvrB [H]

Synonym: Sala_0275

Alternate gene names: 103485770

Gene position: 274570-272384 (Counterclockwise)

Preceding gene: 103485777

Following gene: 103485769

Centisome position: 8.21

GC content: 63.65

Gene sequence:

>2187_bases
ATGGCAATCCAGATTCGCACCTCGCTCGACGAAATCGACACCGCCGAAGGCTATGTGCCGCACCGCCCCGCCCGGCCCGA
CAAGGTCGAAGGCGGCAAGCGATTCGAACTGGTTAGCGACTATGAACCTGCGGGCGATCAGCCGACAGCGATCAGGGAAC
TGGTCGAAACCGCGCGCACGGGCGAACGCGACCAGGTGCTGCTCGGTGTCACCGGATCGGGCAAGACCTTCACCATGGCC
AAGGTGATCGAGGAGTTGCAGCGCCCCGCGCTGATCCTCGCGCCCAACAAGATCCTTGCTGCGCAGCTCTATGGCGAGTT
CAAGAGCTTCTTTCCGAACAATGCCGTCGAGTATTTCGTCAGCTATTACGACTATTACCAGCCCGAAGCCTATGTGCCGC
GTTCGGACACCTATATCGAGAAGGAGTCGAGCGTAAACGAGGCGATCGACCGGATGCGCCATTCGGCGACGCGCGCGCTG
CTCGAACGCGACGATGTCATCATCGTCGCCTCGGTGAGCTGCCTCTATGGCATCGGGTCGGTCGAAACCTACTCCGCGAT
GATCTTCGACCTCAAGAAAGGCCAGGTCGCCGACAACCGTGAGATCATCCGCAAGCTCGTCGCGCTCCAGTACAAACGCA
ACGATCAGGCCTTCGCGCGCGGCAATTTCCGCGTGCGCGGCGACAGCCTCGAAATCTTCCCGTCGCACTATGAGGATATG
GCGTGGCGCGTCAGCTTTTTCGGCGACGAGATCGAGGAGATCACCGAGTTCGACCCGCTGACCGGCAAGAAGATCGCGAG
CCTGAACAGCATCCGCATCTATGCCAACAGCCACTATGTCACGCCCGGCCCGACGCTCAAGCAGGCAACCGAAGCGATCC
GCCACGAACTTGCGGAACGGCTCAAGGAGCTGGAGGCCGAGGGGCGCCTGCTCGAAGCGCAGCGGCTCGAACAGCGCACC
AATTTCGACCTCGAAATGATCGCCGCGACGGGCAGTTGCGCCGGGATCGAGAATTACAGCCGCTTTCTCACCGGCCGCCT
GCCCGGCGAGCCGCCGCCGACCCTGTTCGAATATCTGCCCGACAATGCGCTGCTCTTCGTCGACGAAAGCCACCAGACGA
TCCCGCAGATCGGCGCAATGTCAAAGGGCGACCATCGCCGCAAGATCACCCTCGCCGAATATGGCTTCCGCCTGCCGAGC
TGCATCGACAATAGGCCCTTGCGCTTCGCCGAATGGGACATGATGCGCCCGCAGACGATCAGCGTCTCGGCGACCCCCGG
CACCTGGGAGATGGAGCGCACGCAGGGCGTCTTCGCCGAACAGGTGATCCGCCCCACCGGCCTCATCGACCCGCCGGTCG
AGATCAGGCCGGTCGAGGAACAGGTCGACGACCTGATCGCCGAAGCGAAAAAGACCGCGGCAGCGGGATACCGCACGCTG
GTGACGACTCTGACCAAGCGCATGGCCGAGGATTTGACCGAGTTTCTGCACGAAGCGGGGCTCAAGGTCCGCTACATGCA
CTCGGACGTCGAAACGCTCGAACGCATCGAGATTATCCGCGACCTCCGGCTCGGCGTGTTCGACGTGCTCGTCGGCATCA
ACCTGCTCCGCGAAGGGCTCGACATTCCCGAATGCGGGCTCGTCGCGATCCTCGACGCCGACAAGGAGGGCTTTTTGCGC
AGCGAAACCAGCCTCGTCCAGACGATCGGCCGCGCCGCGCGCAACGTCGACGGGCGCGTCATCCTCTACGCCGACCGCAT
CACCGGCAGCATGGAACGCGCGCTGCGCGAAACCGACCGCCGCCGCGAAAAGCAGAAGGCGTATAACGAAGCGCACGGCA
TCACCCCGACGACGATCAAGCGCAACATCGGCGACATCATCGCGCATGTCGCGTCGAAGGACGGCGTCGTCATCGACATC
GGCGAAGACAAGCCCGCGCACATGGTCGGCCACAACCTCCGCGCCTATATCCAGGAACTCGAAAAGAAGATGCGCGATGC
CGCCGCCGACCTGGAGTTCGAGGAAGCCGGGCGCCTGCGCGACGAAATCCGCAAGCTGGAGGCCGACGAACTGGGCCTGC
CCCCCGACCAACAGGTCGCGCCGCGCGTGGGCCGCAGCAACGAGGGCAAGCCGGGGACGCGCAAGGGCCGCTTCGGGAAG
CAGAGCAAGACGAAGTGGGGGCGGTGA

Upstream 100 bases:

>100_bases
GTCATCACCTTCTTCATCGCCTGTCTCCTCAAGACTCGCCGCTTCCGCTTTCTCGTCATTGCGATTGTGGACCCGCTCCA
TCGATACCATATTGGCGGCA

Downstream 100 bases:

>100_bases
AGGATTTTCAATTCTGCGTTCAGTTTTGACGTAGATGAACGTTAAACTTTTTGTTGACGGCGTCCGCCGAATCGCCTATC
GCGGCGATCGGAGGTAGACC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MAIQIRTSLDEIDTAEGYVPHRPARPDKVEGGKRFELVSDYEPAGDQPTAIRELVETARTGERDQVLLGVTGSGKTFTMA
KVIEELQRPALILAPNKILAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRAL
LERDDVIIVASVSCLYGIGSVETYSAMIFDLKKGQVADNREIIRKLVALQYKRNDQAFARGNFRVRGDSLEIFPSHYEDM
AWRVSFFGDEIEEITEFDPLTGKKIASLNSIRIYANSHYVTPGPTLKQATEAIRHELAERLKELEAEGRLLEAQRLEQRT
NFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPDNALLFVDESHQTIPQIGAMSKGDHRRKITLAEYGFRLPS
CIDNRPLRFAEWDMMRPQTISVSATPGTWEMERTQGVFAEQVIRPTGLIDPPVEIRPVEEQVDDLIAEAKKTAAAGYRTL
VTTLTKRMAEDLTEFLHEAGLKVRYMHSDVETLERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVAILDADKEGFLR
SETSLVQTIGRAARNVDGRVILYADRITGSMERALRETDRRREKQKAYNEAHGITPTTIKRNIGDIIAHVASKDGVVIDI
GEDKPAHMVGHNLRAYIQELEKKMRDAAADLEFEEAGRLRDEIRKLEADELGLPPDQQVAPRVGRSNEGKPGTRKGRFGK
QSKTKWGR

Sequences:

>Translated_728_residues
MAIQIRTSLDEIDTAEGYVPHRPARPDKVEGGKRFELVSDYEPAGDQPTAIRELVETARTGERDQVLLGVTGSGKTFTMA
KVIEELQRPALILAPNKILAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRAL
LERDDVIIVASVSCLYGIGSVETYSAMIFDLKKGQVADNREIIRKLVALQYKRNDQAFARGNFRVRGDSLEIFPSHYEDM
AWRVSFFGDEIEEITEFDPLTGKKIASLNSIRIYANSHYVTPGPTLKQATEAIRHELAERLKELEAEGRLLEAQRLEQRT
NFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPDNALLFVDESHQTIPQIGAMSKGDHRRKITLAEYGFRLPS
CIDNRPLRFAEWDMMRPQTISVSATPGTWEMERTQGVFAEQVIRPTGLIDPPVEIRPVEEQVDDLIAEAKKTAAAGYRTL
VTTLTKRMAEDLTEFLHEAGLKVRYMHSDVETLERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVAILDADKEGFLR
SETSLVQTIGRAARNVDGRVILYADRITGSMERALRETDRRREKQKAYNEAHGITPTTIKRNIGDIIAHVASKDGVVIDI
GEDKPAHMVGHNLRAYIQELEKKMRDAAADLEFEEAGRLRDEIRKLEADELGLPPDQQVAPRVGRSNEGKPGTRKGRFGK
QSKTKWGR
>Mature_727_residues
AIQIRTSLDEIDTAEGYVPHRPARPDKVEGGKRFELVSDYEPAGDQPTAIRELVETARTGERDQVLLGVTGSGKTFTMAK
VIEELQRPALILAPNKILAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRALL
ERDDVIIVASVSCLYGIGSVETYSAMIFDLKKGQVADNREIIRKLVALQYKRNDQAFARGNFRVRGDSLEIFPSHYEDMA
WRVSFFGDEIEEITEFDPLTGKKIASLNSIRIYANSHYVTPGPTLKQATEAIRHELAERLKELEAEGRLLEAQRLEQRTN
FDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPDNALLFVDESHQTIPQIGAMSKGDHRRKITLAEYGFRLPSC
IDNRPLRFAEWDMMRPQTISVSATPGTWEMERTQGVFAEQVIRPTGLIDPPVEIRPVEEQVDDLIAEAKKTAAAGYRTLV
TTLTKRMAEDLTEFLHEAGLKVRYMHSDVETLERIEIIRDLRLGVFDVLVGINLLREGLDIPECGLVAILDADKEGFLRS
ETSLVQTIGRAARNVDGRVILYADRITGSMERALRETDRRREKQKAYNEAHGITPTTIKRNIGDIIAHVASKDGVVIDIG
EDKPAHMVGHNLRAYIQELEKKMRDAAADLEFEEAGRLRDEIRKLEADELGLPPDQQVAPRVGRSNEGKPGTRKGRFGKQ
SKTKWGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=60, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=303, Percent_Identity=22.4422442244224, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 82107; Mature: 81976

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQIRTSLDEIDTAEGYVPHRPARPDKVEGGKRFELVSDYEPAGDQPTAIRELVETART
CEEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHC
GERDQVLLGVTGSGKTFTMAKVIEELQRPALILAPNKILAAQLYGEFKSFFPNNAVEYFV
CCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
SYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRALLERDDVIIVASVSCLYGIGS
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCC
VETYSAMIFDLKKGQVADNREIIRKLVALQYKRNDQAFARGNFRVRGDSLEIFPSHYEDM
HHHHHHHEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCEEEECCCEEECCCCHHHH
AWRVSFFGDEIEEITEFDPLTGKKIASLNSIRIYANSHYVTPGPTLKQATEAIRHELAER
HEEHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHH
LKELEAEGRLLEAQRLEQRTNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLP
HHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHCC
DNALLFVDESHQTIPQIGAMSKGDHRRKITLAEYGFRLPSCIDNRPLRFAEWDMMRPQTI
CCEEEEEECCCCHHHHHCCCCCCCCCEEEEHHHHCCCCCHHHCCCCCEEHHHCCCCCCEE
SVSATPGTWEMERTQGVFAEQVIRPTGLIDPPVEIRPVEEQVDDLIAEAKKTAAAGYRTL
EEEECCCCCCHHHHHCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
VTTLTKRMAEDLTEFLHEAGLKVRYMHSDVETLERIEIIRDLRLGVFDVLVGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DIPECGLVAILDADKEGFLRSETSLVQTIGRAARNVDGRVILYADRITGSMERALRETDR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
RREKQKAYNEAHGITPTTIKRNIGDIIAHVASKDGVVIDIGEDKPAHMVGHNLRAYIQEL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
EKKMRDAAADLEFEEAGRLRDEIRKLEADELGLPPDQQVAPRVGRSNEGKPGTRKGRFGK
HHHHHHHHCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCC
QSKTKWGR
CCCCCCCC
>Mature Secondary Structure 
AIQIRTSLDEIDTAEGYVPHRPARPDKVEGGKRFELVSDYEPAGDQPTAIRELVETART
EEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHC
GERDQVLLGVTGSGKTFTMAKVIEELQRPALILAPNKILAAQLYGEFKSFFPNNAVEYFV
CCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
SYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRALLERDDVIIVASVSCLYGIGS
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCC
VETYSAMIFDLKKGQVADNREIIRKLVALQYKRNDQAFARGNFRVRGDSLEIFPSHYEDM
HHHHHHHEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCEEEECCCEEECCCCHHHH
AWRVSFFGDEIEEITEFDPLTGKKIASLNSIRIYANSHYVTPGPTLKQATEAIRHELAER
HEEHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHH
LKELEAEGRLLEAQRLEQRTNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLP
HHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHCC
DNALLFVDESHQTIPQIGAMSKGDHRRKITLAEYGFRLPSCIDNRPLRFAEWDMMRPQTI
CCEEEEEECCCCHHHHHCCCCCCCCCEEEEHHHHCCCCCHHHCCCCCEEHHHCCCCCCEE
SVSATPGTWEMERTQGVFAEQVIRPTGLIDPPVEIRPVEEQVDDLIAEAKKTAAAGYRTL
EEEECCCCCCHHHHHCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
VTTLTKRMAEDLTEFLHEAGLKVRYMHSDVETLERIEIIRDLRLGVFDVLVGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DIPECGLVAILDADKEGFLRSETSLVQTIGRAARNVDGRVILYADRITGSMERALRETDR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
RREKQKAYNEAHGITPTTIKRNIGDIIAHVASKDGVVIDIGEDKPAHMVGHNLRAYIQEL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
EKKMRDAAADLEFEEAGRLRDEIRKLEADELGLPPDQQVAPRVGRSNEGKPGTRKGRFGK
HHHHHHHHCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCC
QSKTKWGR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA