Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949

Photorhabdus_asymbiotica
Names Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949
Accession numbers NC_012962
Background Photorhabdus asymbiotica, an emerging Gram-negative pathogen, has been recovered from human infections in both N. America and Australia. It has a complicated lifecycle, that at least for the Australia strain, involves a symbiotic association with a nematode host as well a virulent association with an insect host. The human infection in the Australian case probably resulted from contamination with soil bearing either the nematode or insect carcasses.Strain ATCC 43949 was isolated in 1977 from an 80 year old female patient with endocarditis, in Maryland, USA. It has a smaller genome compared to the related insect pathogen P. luminescens strain TT01 (PHOLL), with each pathogen encoding approximately 1 megabase of unique DNA. P. asymbiotica has lost some insecticidal genes, however it is still pathogenic to insects. It has also acquired a plasmid related to pMT1 from Yersinia pestis, with an associated type III secretion system, which may be implicated in its virulence in man (adapted from PMID 19583835). (HAMAP: PHOAA)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Gammaproteobacteria
Order:Enterobacteriales
Family:Enterobacteriaceae
Genus:Photorhabdus
Species:asymbiotica
Strain NA
Complete Yes
Sequencing centre (14-JUL-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(21-MAY-2008) Crossman L.C., Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site blood of an 80 year old female patient with endocarditis, in Maryland, USA.
Isolation country USA
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Facultative
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Symbiotic
Host name Homo sapiens
Cell arrangement NA
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Wound infections, bacteremia
Pathogenicity Yes