Methylobacterium extorquens AM1
Names | Methylobacterium extorquens AM1 |
---|---|
Accession numbers | NC_012807, NC_012808, NC_012809, NC_012810, NC_012811 |
Background | Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) is a pink-pigmented facultative methylotrophs Gram-negative bacterium isolated in 1960 in Oxford, as an airborne contaminant growing on methylamine. It was used as a workhorse to characterize the serine cycle for assimilation of the C1-unit of methylene tetrahydrofolate, a central intermediate in methylotrophic metabolism, and more recently the ethylmalonyl-CoA pathway for glyoxylate regeneration. The common trait of all Methylobacterium species is the ability to grow on one or several reduced one carbon (C1) compounds other than methane, most prominently methanol. M. extorquens contains large sets of insertion elements, many of them strain-specific, suggesting an important potential for genomic plasticity. Most of the genomic determinants associated with methylotrophy are nearly identical in all strains with exceptions that illustrate the metabolic and genomic versatility of Methylobacterium species. M.extorquens (strain ATCC 14718 / DSM 1338 / AM1) possesses a unique methylamine utilization (mau) gene cluster, indicating that strain DSM 5838 / DM4 employs an alternative system for growth with methylamine. The mau clusters represent a chromosomal genomic island and is flanked by mobile elements.(Adaptated from PMID: 19440302). (EBI Integr8) |
Taxonomy | |
Kingdom: | Bacteria |
Phylum: | Proteobacteria |
Class: | Alphaproteobacteria |
Order: | Rhizobiales |
Family: | Methylobacteriaceae |
Genus: | Methylobacterium |
Species: | extorquens |
Strain | AM1 |
Complete | Yes |
Sequencing centre | (13-MAR-2009) Genome Center, University of Washington, Box 352145, Seattle, WA 98195, USA (17-JUN-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA |
Sequencing quality | Level 6: Finished |
Sequencing depth | NA |
Sequencing method | Sanger |
Isolation site | Air |
Isolation country | NA |
Number of replicons | 5 |
Gram staining properties | Negative |
Shape | Bacilli |
Mobility | Yes |
Flagellar presence | No |
Number of membranes | 2 |
Oxygen requirements | Facultative |
Optimal temperature | 25.0 |
Temperature range | Mesophilic |
Habitat | Multiple |
Biotic relationship | Free living |
Host name | NA |
Cell arrangement | Pairs, Singles |
Sporulation | Nonsporulating |
Metabolism | NA |
Energy source | Methylotroph |
Diseases | NA |
Pathogenicity | No |
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fatty acid metabolism
Synthesis and degradation of ketone bodies
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine degradation
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
Chloroalkane and chloroalkene degradation
Glyoxylate and dicarboxylate metabolism
Propanoate metabolism
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Methane metabolism
Carbon fixation in photosynthetic organisms
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Nitrogen metabolism
Sulfur metabolism
Aminoacyl-tRNA biosynthesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fatty acid metabolism
Synthesis and degradation of ketone bodies
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine degradation
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
Chloroalkane and chloroalkene degradation
Glyoxylate and dicarboxylate metabolism
Propanoate metabolism
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Methane metabolism
Carbon fixation in photosynthetic organisms
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Nitrogen metabolism
Sulfur metabolism
Aminoacyl-tRNA biosynthesis