Brucella melitensis ATCC 23457

Names Brucella melitensis ATCC 23457
Accession numbers NC_012441, NC_012442
Background The genus Brucella is comprised mostly of mammalian pathogens, which due to their low infectious does, aerosol transmission and treatment difficulty are classified as potential bioterrorism agents. Brucellosis is a major infectious disease for both human and animals. Several Brucella species (B.abortus, B.melitensis and B.suis) have been isolated from many different animals. All three Brucella species cause a severe human disease characterized in its acute phase by undulant fever and in its chronic phase by damage of different organs. Brucellosis is a major problem in the Mediterranean region and parts of Asia, Africa and Latin America. When the infection is localized to the brain or the heart, it can result in a fatal meningitidis or fatal endocarditis, respectively. Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and undulant fever in humans. The disease is transmitted to human by consumption of non-pasteurized milk and milk products or by direct contact with infected animals and carcasses. Although Brucellae contain a large set of flagellar genes, they display a species-specific gene inactivation and consequently are nonmotile. Strain M28 is a virulent strain isolated from sheep in the 1950s. It is the parent of vaccine strain M5-90 (biovar1) which was isolated after M28 was serially passaged through chickens, treated with acriflavine, and passaged for 90 generations in chicken embryo fibroblasts. Comparison of the 2 sequences will give information on vaccine protection (adapted from PMID 21478357). (EBI Integr8)
Strain ATCC 23457
Complete Yes
Sequencing centre (09-MAR-2009) The Pathosystems Resource Integration Center (PATRIC), Virginia Bioinformatics Institute at Virginia
(25-MAR-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site human blood and bone marrow samples
Isolation country India
Number of replicons 2
Gram staining properties Negative
Shape Cocci
Mobility No
Flagellar presence No
Number of membranes 2
Oxygen requirements Facultative
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Chains, Pairs, Singles
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Brucellosis
Pathogenicity Yes