Campylobacter lari RM2100

Names Campylobacter lari RM2100
Accession numbers NC_012039, NC_012040
Background Gram-negative, microaerophilic, flagellate, spiral bacterium, Campylobacter species are the leading cause of food-borne gastroenteritis in developed countries. Campylobacter lari is a thermotolerant member of the Campylobacter group found in birds, especially seagulls, as well as mammals. This strain, RM2100 is a clinical isolate; C.laris rarely causes bacteremia, usually does so in immunocompromised patients. RM2100 encodes a 36 kb putative prophage which is similar to a putative prophage present within the C. jejuni RM1221 genome. Nearly all (90%) of the gene content in strain RM2100 is similar to genes present in the genomes of other characterized thermotolerant campylobacters. However, several genes involved in amino acid biosynthesis and energy metabolism are absent from the C.lari RM2100 genome, which is thus predicted to be multiply auxotrophic, unable to synthesize eight different amino acids, acetyl-coA, and pantothenate. Additionally, this strain does not contain a complete TCA cycle and is missing the CydAB terminal oxidase of the respiratory chain. The apparent absence of certain key enzymatic functions in strain RM2100 would be expected to have an impact on C. lari biology. It is also possible that the reduction in the C. lari metabolic machinery is related to its environmental range and host preference (adapted from PubMed 18713059). (HAMAP: CAMLR)
Strain RM2100
Complete Yes
Sequencing centre (05-FEB-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(25-JAN-2008) Produce Safety and Microbiology, USDA, ARS, WRRC, 800 Buchanan St., Albany, CA 94710, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site Human clinical isolate
Isolation country NA
Number of replicons 2
Gram staining properties Negative
Shape Spirilla
Mobility No
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Microaerophilic
Optimal temperature NA
Temperature range Mesophilic
Habitat Multiple
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Chains, Singles
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Gastroenteritis and diarrhea
Pathogenicity Yes