Rickettsia conorii str. Malish 7

Rickettsia_conorii
Names Rickettsia conorii str. Malish 7
Accession numbers NC_003103
Background Rickettsia are obligate intracellular bacteria normally living in arthropod cells. They occasionally cause diseases in humans. R. conorii is the agent of Mediterranean spotted fever, which is transmitted by brown dog ticks.The bacterium is closely related to R. prowazekii, which causes typhus. Both bacteria are parasites with a relatively small genome, in part because they tend to inactivate their own genes when they can make use of genes from their host. The R. conorii genome has 1.3 million base pairs and 1,374 genes, slightly more than its cousin. The overlap for parts of the genomes is striking: All but thirty genes from a set of 834 in R. prowazekii have counterparts in R. conorii.R. conorii requires an arthropod (insect) vector for transmission. Transovarian transmission of the pathogen from one generation of insect to the next is important in many rickettsial diseases. From the portal of entry in the skin, rickettsiae spread via the bloodstream to infect the endothelium and sometimes the vascular smooth muscle cells. Common symptons of disease in humans include nausea, vomiting, abdominal pain, encephalitis, hypotension, acute renal failure, and respiratory distress.(From http://www.ebi.ac.uk/2can/genomes/bacteria.html) (BacMap)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Alphaproteobacteria
Order:Rickettsiales
Family:Rickettsiaceae
Genus:Rickettsia
Species:conorii
Strain Malish 7
Complete Yes
Sequencing centre (02-OCT-2001) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(10-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Human in South Africa
Isolation country South Africa
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Symbiotic
Host name Homo sapiens
Cell arrangement NA
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Rocky Mountain Spotted Fever
Pathogenicity Yes