Pseudomonas aeruginosa LESB58

Pseudomonas_aeruginosa
Names Pseudomonas aeruginosa LESB58
Accession numbers NC_011770
Background Members of the genus Pseudomonas are characterized by their ability to grow in simple media at the expense of a great variety of organic compounds. They have a strict respiratory metabolism and are motile by one or several polar flagella. They are common inhabitants of soil and water and can also be found on the surfaces of plants and animals. They are are found in nature in a biofilm or in planktonic form. Pseudomonas aeruginosa is an important soil bacterium, with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. Human pathogenic strains usually prey on immunocompromised patients.The widespread assumption that cystic fibrosis (CF) patients acquire only unique strains of P. aeruginosa from the environment was challenged when molecular typing was used to demonstrate the spread of a beta-lactam-resistant isolate, now known as the Liverpool Epidemic Strain (LES), at a children's CF unit in Liverpool, United Kingdom. LES is the most frequent clone isolated from CF patients in England and Wales and has also been reported in Scotland. It can cause superinfection, exhibits enhanced survival on dry surfaces, and is associated with greater patient morbidity than other P. aeruginosa strains. The earliest archived LES isolate, LESB58 was obtained from a Liverpool CF patient in 1988, 8 years prior to the first published study on the LES. It is characterized by early (in the growth curve) overexpression of the cell-density-dependent quorum sensing regulon, including virulence-related secreted factors such as LasA, elastase, and pyocyanin. Furthermore, LESB58 is known to be a biofilm hyperproducer (adapted from PubMed 19047519). (HAMAP: PSEA8)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Gammaproteobacteria
Order:Pseudomonadales
Family:Pseudomonadaceae
Genus:Pseudomonas
Species:aeruginosa
Strain LESB58
Complete Yes
Sequencing centre (02-SEP-2008) Thomson N.R., Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge,
(25-DEC-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Liverpool Cystic Fibrosis (CF) clinic center
Isolation country United Kingdom
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility Yes
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat Multiple
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Singles
Sporulation Nonsporulating
Metabolism NA
Energy source Heterotroph
Diseases Lung infections
Pathogenicity Yes