Borrelia recurrentis A1

Names Borrelia recurrentis A1
Accession numbers NC_011244, NC_011246, NC_011252, NC_011253, NC_011255, NC_011258, NC_011260, NC_011263
Background Relapsing fever (RF) is a disease caused by several spirochetes of the genus Borrelia. Relapsing fever borrelioses are characterized by recurrent febrile episodes and spirochetemia. There are 2 forms; louse-borne relapsing fever (also known as urban or epidemic RF) is caused by Borrelia recurrentis, and is transmitted by the body louse Pediculus humanus humanus. It currently known in Ethiopia. Endemic tick-borne relapsing fever (TBRF) is a zoonotic disease transmitted worldwide by softbody ticks of the genus Ornithodoros. It is caused by at least 15 distinct Borrelia species throughout the world.Borrelia recurrentis strain A1 was isolated from an adult with RF in Ethiopia. RF causes fewer relapses that TBRF but has a higher spontaneous mortality rate despite antibiotics. Previous work suggested that B.recurrentis was very closely related to B.duttonii; the current sequencing project suggests that in fact B.recurrentis should be considered a strain of B.duttonii that is undergoing considerable gene decay. Decay is probably due at least in part to mutated recA and mutS genes in A1. All 6 plasmids in strain A1 have a counterpart in B.duttonii strain Ly (BORDL). (HAMAP: BORRA)
Strain A1
Complete Yes
Sequencing centre (17-MAR-2008) Institut de Biologie structurale et Microbiologie (IBSM), CNRS-Information Genomique et structurale,
(17-SEP-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Adult patient with louse-borne relapsing fever in Ethiopia
Isolation country Ethiopia
Number of replicons 8
Gram staining properties Negative
Shape Spirilla
Mobility No
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Singles
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Louse-borne relapsing fever
Pathogenicity Yes