Burkholderia cenocepacia J2315

Burkholderia_cenocepacia
Names Burkholderia cenocepacia J2315
Accession numbers NC_011000, NC_011001, NC_011002, NC_011003
Background The Burkholderia cepacia complex (Bcc) comprises at least nine closely related species which can be correctly identified only by polyphasic taxonomic approaches. Members of the complex are among the most metabolically versatile microorganisms known as they grow on more than 200 organic compounds, fix N2 and carry multiple antibiotic resistances. They are involved in important processes such as biodegradation of pollutants, biocontrol of root diseases but some also cause disease in plants, animals and humans. Bcc strains are isolated from very different habitats, including soil, rhizospheres, streams and infected plants, animals and human tissues, especially lungs of cystic fibrosis (CF) patients. Bcc strains have large and plastic genomes comprised of multiple (2 to 4) replicons, which is thought to give them their ecological versatility. Burkholderia cenocepacia is a Gram-negative bacterium which is ubiquitous in the environment and may cause a number of diseases in plants. Human infection can be caused by B.cenocepacia, especially in patients with CF and chronic granulomatous disease, and is often fatal. B.cenocepacia (strain AU1054) was recovered from the blood of a patient with CF. It is characterized as a representative of the B.cenocepacia PHDC clonal lineage. This clone appears to be widely distributed, having been found in CF patients in 24 US states and Europe, as well as in agricultural soil. Its genome consists of 3 chromosomes of 3.2 Mb, 2.6 Mb and 1.1 Mb (adapted from http://genome.jgi-psf.org/burca/burca.home.html). (HAMAP: BURCA)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Betaproteobacteria
Order:Burkholderiales
Family:Burkholderiaceae
Genus:Burkholderia
Species:cenocepacia
Strain J2315
Complete Yes
Sequencing centre (20-JUN-2007) Holden M.T.G., The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, The Wellcome Trust
(22-SEP-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Patient with cystic fibrosis in Edinburgh, UK
Isolation country United Kingdom
Number of replicons 4
Gram staining properties Negative
Shape Bacilli
Mobility Yes
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Facultative
Optimal temperature NA
Temperature range Mesophilic
Habitat Multiple
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source NA
Diseases Necrotizing pneumonia and chronic infections
Pathogenicity Yes
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Galactose metabolism
Ascorbate and aldarate metabolism
Fatty acid metabolism
Synthesis and degradation of ketone bodies
Ubiquinone and other terpenoid-quinone biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine degradation
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Benzoate degradation
Fluorobenzoate degradation
Tryptophan metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
beta-Alanine metabolism
Taurine and hypotaurine metabolism
Selenocompound metabolism
Cyanoamino acid metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
Chloroalkane and chloroalkene degradation
Glyoxylate and dicarboxylate metabolism
Propanoate metabolism
Ethylbenzene degradation
Styrene degradation
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Nitrogen metabolism
Sulfur metabolism
Aminoacyl-tRNA biosynthesis