Treponema denticola ATCC 35405

Treponema_denticola
Names Treponema denticola ATCC 35405
Accession numbers NC_002967
Background Treponema denticola is an obligate anaerobe and is one of a number of spirochetes found in the oral cavity of humans. It is commonly associated with periodontal disease, an inflammation of gum tissue that frequently precedes bone resorbtion and subsequent tooth loss.The bacterial flora in gingival lesions produce a complex biofilm in which T. denticola and other treponemes form a prominent layer. With the decreased incidence of dental caries (cavities), periodontal disease has become a major concern in dentistry. It is estimated that 80% of adults in the U.S. have had periodontal disease at some time in their lives. T. denticola can invade gingival tissues and establish endodontic (tooth root canal) infections.T. denticola DNA and antigens have been detected in atherosclerotic lesions of the aorta in human patients. An association between preterm birth/low birth weight of infants and periodontal disease in the mother has also been described. Of veterinary importance, organisms closely related to T. denticola also cause digital dermatitis in cattle.Although T. denticola is related to T. pallidum, the syphilis spirochete, these organisms differ by more than 10%.(From http://www.ebi.ac.uk/2can/genomes/bacteria.html) (BacMap)
Taxonomy
Kingdom:Bacteria
Phylum:Spirochaetes
Class:Spirochaetes
Order:Spirochaetales
Family:Spirochaetaceae
Genus:Treponema
Species:denticola
Strain ATCC 35405
Complete Yes
Sequencing centre (11-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(29-JAN-2004) The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method WGS
Isolation site human periodontal pocket
Isolation country NA
Number of replicons 1
Gram staining properties Negative
Shape Spirilla
Mobility No
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Anaerobic
Optimal temperature 30.0
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Singles
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Periodontal disease, gum inflamation
Pathogenicity Yes