Lactobacillus reuteri JCM 1112

Lactobacillus_reuteri
Names Lactobacillus reuteri JCM 1112
Accession numbers NC_010609
Background Lactobacilli are normal inhabitants of the gastrointestinal tract of man and animals where they are widely considered to exert a number of beneficial roles including immunomodulation, interference with enteric pathogens, and maintenance of a healthy intestinal microflora. The genus Lactobacillus presently comprises more than 50 recognized species of non pathogenic bacteria which in addition to their probiotic effects are useful to human as indispensable agents for the fermentation of foods and feed.L. reuteri DSM 20016 T was isolated from the intestine of an adult human and is the type culture for the species. It encodes a unique cluster of 58 genes for the biosynthesis of reuterin and cobalamin (vitamin B12) that are not found in rat-derived strains. Although it shares a common origin with JCM 1112 (LACRJ), both being derived from F275, the two strains have been maintained separately for over 20 years and there are 2 regions unique to JCM 1112 that result in a 40 kb increase in genome size in JCM 1112, in addition to point mutations. In contrast to rat-derived L. reuteri strain 100-23, this strain is unable to colonize the mouse gastrointestinal tract. Comparing with rodent-derived strains 100-23 shows distinct genome inventories in host-restricted sub-populations of L. reuteri that reflects the niche characteristics in the gut of their particular vertebrate hosts, and thus L.reuteri has evolved a lifestyle specialized to these host animals (adapted from PMID 21379339). (HAMAP: LACRD)
Taxonomy
Kingdom:Bacteria
Phylum:Firmicutes
Class:Bacilli
Order:Lactobacillales
Family:Lactobacillaceae
Genus:Lactobacillus
Species:reuteri
Strain JCM 1112
Complete Yes
Sequencing centre (21-APR-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(21-OCT-2004) Contact:Masahira Hattori University of Tokyo, Graduate School of Frontier Sciences
5-1-5 Kashiwanoha,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger, 454
Isolation site Human feces
Isolation country NA
Number of replicons 1
Gram staining properties Positive
Shape Bacilli
Mobility No
Flagellar presence NA
Number of membranes 1
Oxygen requirements Facultative
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Chains
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases None
Pathogenicity No