Proteus mirabilis HI4320

Proteus_mirabilis
Names Proteus mirabilis HI4320
Accession numbers NC_010554, NC_010555
Background The gram-negative enteric bacterium Proteus mirabilis, a human commensal bacterium, is a frequent cause of urinary tract infections in individuals with long-term indwelling catheters or with complicated urinary tracts (e.g., due to spinal cord injury or anatomic abnormality). Infection may lead to acute pyelonephritis, fever, bacteremia, the formation of kidney and bladder stones or the encrustation or obstruction of indwelling urinary catheters. It is highly motile and differentiates from short vegetative swimmer cells to an elongated, highly flagellated swarmer form. It has strong adherence abilities, which enable it to infect the bladder, kidney and even penetrate into the bloodstream. Strain HI4320 was isolated from the urine of a nursing home patient with a long-term (>30 days) indwelling urinary catheter. It is not only able to degrade urine but analysis of the genome suggests it may also be able to synthesize it. The genome encodes 17 types of fimbriae, more than in any other bacterium sequenced to date, highlighting the importance of adherence to this organism. This strain is considered a low-passage clinical isolate (adapted from PubMed 18375554). (HAMAP: PROMH)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Gammaproteobacteria
Order:Enterobacteriales
Family:Enterobacteriaceae
Genus:Proteus
Species:mirabilis
Strain HI4320
Complete Yes
Sequencing centre (18-FEB-2008) Sebaihia M., Sulston Laboratories, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
(25-AUG-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site Urine of a nursing home patient with a long term (>30 day) indwelling urinary catheter
Isolation country NA
Number of replicons 2
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature 37.0
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement NA
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Encephalitis, urinary tract infections, surgical wound infections, pyelonephritis, pneumonia, septicemia
Pathogenicity Yes