Corynebacterium urealyticum DSM 7109

Corynebacterium_urealyticum
Names Corynebacterium urealyticum DSM 7109
Accession numbers NC_010545
Background Bacteria from the genus Corynebacterium are Gram-positive, nonmotile rods. C.urealyticum is a strictly aerobic, lipid-requiring, urealytic bacterium of the human skin flora that causes urinary tract infections; strain DSM 7109 was recovered from a patient with alkaline-encrusted cystitis. Metabolic analysis of the lipid-requiring phenotype revealed the absence of a fatty acid synthase gene and the presence of a beta-oxidation pathway along with a large repertoire of auxillary genes for the degradation of exogenous fatty acids. A urease locus may play a pivotal role in virulence of C. urealyticum by the alkalinization of human urine and the formation of struvite stones. Multidrug resistance in DSM 7109 is mediated by transposable elements, conferring resistances to macrolides, lincosamides, ketolides, aminoglycosides, chloramphenicol, and tetracycline (modified from PubMed 18367281). (EBI Integr8)
Taxonomy
Kingdom:Bacteria
Phylum:Actinobacteria
Class:Actinobacteria
Order:Actinomycetales
Family:Corynebacteriaceae
Genus:Corynebacterium
Species:urealyticum
Strain DSM 7109
Complete Yes
Sequencing centre (03-APR-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(18-FEB-2008) Linke B., Center For Biotechnology, Bielefeld University, Universitaetsstrasse 25, 33501 Bielefeld,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site Bladder stone
Isolation country NA
Number of replicons 1
Gram staining properties Positive
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 1
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Singles
Sporulation Nonsporulating
Metabolism NA
Energy source Chemoorganotroph
Diseases Urinary tract infection
Pathogenicity Yes