Escherichia coli SMS-3-5
| Names | Escherichia coli SMS-3-5 |
|---|---|
| Accession numbers | NC_010485, NC_010486, NC_010487, NC_010488, NC_010498 |
| Background | Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.E.coli strain SECEC SMS-3-5 was isolated from Shipyard Creek, USA, an industrial, toxic metal-contaminated coastal environment. It is resistant to a record-number of antibiotics, in many cases at record-high concentrations. This is the first case of resistance to ciprofloxacin and moxifloxacin, two front-line fluoroquinolones, in an environmental strain. By multilocus sequence typing it belongs to a clade close to the last common E.coli/Shigella ancestor. It belongs to phylogenetic group D and is serptype O19:H34 (modified from PubMed 18708504 ). (HAMAP: ECOSM) |
| Taxonomy | |
| Kingdom: | Bacteria |
| Phylum: | Proteobacteria |
| Class: | Gammaproteobacteria |
| Order: | Enterobacteriales |
| Family: | Enterobacteriaceae |
| Genus: | Escherichia |
| Species: | coli |
| Strain | SMS-3-5 |
| Complete | Yes |
| Sequencing centre | (14-MAR-2008) J. Craig Venter Institute, 9712 Medical Center Dr, Rockville, MD 20850, USA (24-MAR-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA |
| Sequencing quality | Level 6: Finished |
| Sequencing depth | NA |
| Sequencing method | NA |
| Isolation site | Patient in 1922 |
| Isolation country | NA |
| Number of replicons | 5 |
| Gram staining properties | Negative |
| Shape | Bacilli |
| Mobility | No |
| Flagellar presence | Yes |
| Number of membranes | 2 |
| Oxygen requirements | Facultative |
| Optimal temperature | 37.0 |
| Temperature range | Mesophilic |
| Habitat | Multiple |
| Biotic relationship | Free living |
| Host name | Homo sapiens |
| Cell arrangement | Pairs, Singles |
| Sporulation | Nonsporulating |
| Metabolism | NA |
| Energy source | NA |
| Diseases | None |
| Pathogenicity | NA |
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Ascorbate and aldarate metabolism
Fatty acid metabolism
Ubiquinone and other terpenoid-quinone biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
beta-Alanine metabolism
Taurine and hypotaurine metabolism
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Alanine metabolism
Glutathione metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Glycerolipid metabolism
Glycerophospholipid metabolism
Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism
Nitrotoluene degradation
Propanoate metabolism
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Terpenoid backbone biosynthesis
Nitrogen metabolism
Sulfur metabolism
Aminoacyl-tRNA biosynthesis
Biosynthesis of siderophore group nonribosomal peptides
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Ascorbate and aldarate metabolism
Fatty acid metabolism
Ubiquinone and other terpenoid-quinone biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
beta-Alanine metabolism
Taurine and hypotaurine metabolism
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Alanine metabolism
Glutathione metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Glycerolipid metabolism
Glycerophospholipid metabolism
Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism
Nitrotoluene degradation
Propanoate metabolism
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Terpenoid backbone biosynthesis
Nitrogen metabolism
Sulfur metabolism
Aminoacyl-tRNA biosynthesis
Biosynthesis of siderophore group nonribosomal peptides