Chlamydia trachomatis 434/Bu

Chlamydia_trachomatis
Names Chlamydia trachomatis 434/Bu
Accession numbers NC_010287
Background Chlamydia trachomatis infection is an important cause of preventable blindness and sexually transmitted disease (STD) in humans. There are 15 serovariants that exhibit distinct organotropism for the eye or the urogenital tract and are separated according to the pathobiotypes. Trachoma biovariants consist of serovars A, B, Ba, C, D, E, F, G, H, I, J and K. LGV (Lymphogranuloma venereum) biovariants consist of serovars L1, L2 and L3. Trachoma biovariants are noninvasive and epitheliotropic strains that cause blinding trachoma (A to C) or sexually transmitted diseases. LGV biovariants cause sexually transmitted diseases with disseminating infection of draining regional lymph nodes. The trpBA operon encoding tryptophan synthase is functional in STD serovars, whereas trpBA harbors mutations that inactivate the enzyme in ocular serovars. Chlamydia trachomatis is an obligate intracellular parasite depending on the host machinery for ATP synthesis. Chlamydial life cycle comprehends an intracellular metabolically- active "reticular body" and an inert extracellular spore-like "elementary body" equipped with a unique disulfide-cross-linked protein envelope.Chlamydia trachomatis (strain L2/434/Bu / ATCC VR902B) belongs to the LGV serovar. It was originally isolated from an inguinal bubo of a LGV case 40 years ago in California. LGV strains are more invasive than those of serovars A-K. They cause systemic infections, infect monocytes and disseminate to the local lymph nodes where they can cause large swellings characteristic of bubonic diseases. LGV serovars are endemic in parts of Africa, South East Asia, South America and the Caribbean. The incidence of LGV is low in the West, however a recent outbreak has been reported in the Netherlands. The typical characteristics of LGV in the tropics, genital ulcerations and inguinal buboes, were absent and the patients rather presented proctitis. This may explain the initial difficulties encountered in describing the outbreak. (HAMAP: CHLT2)
Taxonomy
Kingdom:Bacteria
Phylum:Chlamydiae
Class:Chlamydiae
Order:Chlamydiales
Family:Chlamydiaceae
Genus:Chlamydia
Species:trachomatis
Strain 434/Bu
Complete Yes
Sequencing centre (24-JAN-2003) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(29-AUG-2007) Thomson N.R., Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site NA
Isolation country NA
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence Yes
Number of membranes 2
Oxygen requirements NA
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Symbiotic
Host name Homo sapiens
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source NA
Diseases Lymphogranuloma vernerum
Pathogenicity Yes