Chlamydia trachomatis L2b/UCH-1/proctitis

Names Chlamydia trachomatis L2b/UCH-1/proctitis
Accession numbers NC_010280
Background Chlamydia trachomatis infection is an important cause of preventable blindness and sexually transmitted disease (STD) in humans. There are 15 serovariants that exhibit distinct organotropism for the eye or the urogenital tract and are separated according to the pathobiotypes. Trachoma biovariants consist of serovars A, B, Ba, C, D, E, F, G, H, I, J and K. LGV (Lymphogranuloma venereum) biovariants consist of serovars L1, L2 and L3. Trachoma biovariants are noninvasive and epitheliotropic strains that cause blinding trachoma (A to C) or sexually transmitted diseases. LGV biovariants cause sexually transmitted diseases with disseminating infection of draining regional lymph nodes. The trpBA operon encoding tryptophan synthase is functional in STD serovars, whereas trpBA harbors mutations that inactivate the enzyme in ocular serovars. Chlamydia trachomatis is an obligate intracellular parasite depending on the host machinery for ATP synthesis. Chlamydial life cycle comprehends an intracellular metabolically- active "reticular body" and an inert extracellular spore-like "elementary body" equipped with a unique disulfide-cross-linked protein envelope. Chlamydia trachomatis (strain D/UW-3) is a genitotropic isolate. (EBI Integr8)
Strain L2b/UCH-1/proctitis
Complete Yes
Sequencing centre (24-JAN-2003) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(29-AUG-2007) Thomson N.R., Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger, 454-GS20
Isolation site rectal swab of a 49-yr-old MSM who was HIV positive and Hepatitis C negative
Isolation country United Kingdom
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 2
Oxygen requirements NA
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Symbiotic
Host name Homo sapiens
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source NA
Diseases Lymphogranuloma vernerum, proctitis
Pathogenicity Yes