Mycobacterium bovis AF2122/97

Mycobacterium_bovis
Names Mycobacterium bovis AF2122/97
Accession numbers NC_002945
Background Mycobacterium bovis is a Gram positive non-spore forming, non-motile, slightly curved, aerobic, slow-growing bacterium. It is the causative agent of tuberculosis in cattle and other animals, including buffalo, lions and antelopes . The organism can also cause tuberculosis in humans.Its genome is 99.95 percent identical to that of M. tuberculosis. It is also part of the Mycobacterium complex which also includes M. tuberculosis and M. avium.Bovine Tuberculosis is a contagious, debilitating disease of both humans and animals. The primary site of infection is the lymph nodes, but it will spread to other organs such as the lungs as the disease progresses. Clinical signs of the disease include weakness, loss of appetite, weight loss and fever. Bovine TB is a chronic disease, and infected animals may take several years to develop clinical signs or may show no evidence of infection until they are sent to slaughter. Because the disease in cattle may not be clinically evident, even in advanced stages, diagnosis is often made upon post mortem examination at slaughter. Nodular lesions may be found in any organ or body cavity, but are usually seen in the lungs and associated lymph nodes of the head, respiratory and gastrointestinal tracts.The current vaccine against TB, the so-called BCG vaccine (short for 'Bacillus Calmette-Guerin') is not very effective. It is made from a live but weakened strain of Mycobacterium bovis. (From http://www.ebi.ac.uk/2can/genomes/bacteria.html) (BacMap)
Taxonomy
Kingdom:Bacteria
Phylum:Actinobacteria
Class:Actinobacteria
Order:Actinomycetales
Family:Mycobacteriaceae
Genus:Mycobacterium
Species:bovis
Strain AF2122/97
Complete Yes
Sequencing centre (08-APR-2002) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(24-MAR-2003) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(24-MAR-2003) Unite de Genetique Moleculaire Bacterienne Institut Pasteur, 28 rue du Docteur Roux, Paris Cedex 15 75724,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site In 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes
Isolation country United Kingdom
Number of replicons 1
Gram staining properties Positive
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 1
Oxygen requirements Aerobic
Optimal temperature 37.0
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Cow, Homo sapiens
Cell arrangement Singles
Sporulation Nonsporulating
Metabolism NA
Energy source Chemoorganotroph
Diseases Tuberculosis in cattle
Pathogenicity Yes