Salinispora tropica CNB-440

Salinispora_tropica
Names Salinispora tropica CNB-440
Accession numbers NC_009380
Background Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) is an aerobic seawater-requiring marine actinomycete isolated from coarse beach sand off the Bahamas. The genus Salinispora is distinct from other actinomycetes however in that it resides in ocean sediments and is the first bacterium of its type to require seawater for growth thus providing opportunities to study marine adaptations in Gram-positive bacteria. One significant feature of S. tropica is its ability to produce structurally unique secondary metabolites. This observation supports the exploitation of marine actinomycetes as a source of new medicines. The metabolites observed from S. tropica include salinosporamide A, a potent inhibitor of the 20S proteasome that is currently in human clinical trials for the treatment of cancer. Interestingly, it has been observed that the three closely related Salinispora species produce dramatically different suites of secondary metabolites. These metabolites represent the single most significant phenotypic difference observed among the three species and raise questions about the ecological roles and evolutionary significance of secondary metabolites. (EBI Integr8)
Taxonomy
Kingdom:Bacteria
Phylum:Actinobacteria
Class:Actinobacteria
Order:Actinomycetales
Family:Micromonosporaceae
Genus:Salinispora
Species:tropica
Strain CNB-440
Complete Yes
Sequencing centre (10-APR-2007) US DOE Joint Genome Institute, 2800 Mitchell Drive B100, Walnut Creek, CA 94598-1698, USA
(23-APR-2007) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site Coarse beach sand off the Bahamas
Isolation country Bahamas
Number of replicons 1
Gram staining properties Positive
Shape NA
Mobility Yes
Flagellar presence No
Number of membranes 1
Oxygen requirements Aerobic
Optimal temperature 28.0
Temperature range Mesophilic
Habitat Aquatic
Biotic relationship Free living
Host name NA
Cell arrangement Clusters, Singles
Sporulation Sporulating
Metabolism NA
Energy source NA
Diseases None
Pathogenicity No