Saccharopolyspora erythraea NRRL 2338
| Names | Saccharopolyspora erythraea NRRL 2338 |
|---|---|
| Accession numbers | NC_009142 |
| Background | Saccharopolyspora erythraea (Strain ATCC 11635 / DSM 40517 / NRRL 2338) is an obligate aerobic bacterium phylogenetically associated with the Actinobacteria. This soil bacterium produces the industrially important antibiotic erythromycin A. The genome of S. erythraea is apparently circular rather than linear. This is the white, less-pigmented form, which produced substantially more erythromycin than the red form. Erythromycin is a clinically important and potent macrolide antibiotic. It is used to treat infections caused by several prokaryotic pathogens such as Streptococcus, Staphylococcus, Mycoplasma, Ureaplasma, Chlamydia and Legionella. Production of this antibiotic is lower than others in the same class, such as penicillin or cephalosporin, which has led to the development of a genetic system to attempt to enhance the production of erythromycin. (EBI Integr8) |
| Taxonomy | |
| Kingdom: | Bacteria |
| Phylum: | Actinobacteria |
| Class: | Actinobacteria |
| Order: | Actinomycetales |
| Family: | Pseudonocardiaceae |
| Genus: | Saccharopolyspora |
| Species: | erythraea |
| Strain | NRRL 2338 |
| Complete | Yes |
| Sequencing centre | (10-NOV-2006) Oliynyk M., Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB21GA, (23-MAR-2007) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA |
| Sequencing quality | Level 6: Finished |
| Sequencing depth | NA |
| Sequencing method | NA |
| Isolation site | Soil; Philippines |
| Isolation country | NA |
| Number of replicons | 1 |
| Gram staining properties | Positive |
| Shape | Tailed |
| Mobility | Yes |
| Flagellar presence | No |
| Number of membranes | 1 |
| Oxygen requirements | Aerobic |
| Optimal temperature | 25.0 |
| Temperature range | Mesophilic |
| Habitat | Terrestrial |
| Biotic relationship | Free living |
| Host name | NA |
| Cell arrangement | Filaments |
| Sporulation | Sporulating |
| Metabolism | NA |
| Energy source | NA |
| Diseases | NA |
| Pathogenicity | No |
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fructose and mannose metabolism
Galactose metabolism
Fatty acid metabolism
Synthesis and degradation of ketone bodies
Ubiquinone and other terpenoid-quinone biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine degradation
Geraniol degradation
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine metabolism
Bisphenol degradation
Fluorobenzoate degradation
Tryptophan metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Streptomycin biosynthesis
Biosynthesis of 12-, 14- and 16-membered macrolides
Peptidoglycan biosynthesis
Glycerolipid metabolism
Pyruvate metabolism
Toluene degradation
Chloroalkane and chloroalkene degradation
Naphthalene degradation
Glyoxylate and dicarboxylate metabolism
Nitrotoluene degradation
Propanoate metabolism
Styrene degradation
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Atrazine degradation
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Limonene and pinene degradation
Nitrogen metabolism
Sulfur metabolism
Caprolactam degradation
Aminoacyl-tRNA biosynthesis
Biosynthesis of unsaturated fatty acids
Biosynthesis of ansamycins
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fructose and mannose metabolism
Galactose metabolism
Fatty acid metabolism
Synthesis and degradation of ketone bodies
Ubiquinone and other terpenoid-quinone biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine degradation
Geraniol degradation
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine metabolism
Bisphenol degradation
Fluorobenzoate degradation
Tryptophan metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Streptomycin biosynthesis
Biosynthesis of 12-, 14- and 16-membered macrolides
Peptidoglycan biosynthesis
Glycerolipid metabolism
Pyruvate metabolism
Toluene degradation
Chloroalkane and chloroalkene degradation
Naphthalene degradation
Glyoxylate and dicarboxylate metabolism
Nitrotoluene degradation
Propanoate metabolism
Styrene degradation
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Atrazine degradation
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Limonene and pinene degradation
Nitrogen metabolism
Sulfur metabolism
Caprolactam degradation
Aminoacyl-tRNA biosynthesis
Biosynthesis of unsaturated fatty acids
Biosynthesis of ansamycins