Streptococcus pyogenes M1 GAS

Names Streptococcus pyogenes M1 GAS
Accession numbers NC_002737
Background The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. Strict human pathogen responsible for a wide variety of diseases, including pharyngitis, scarlet fever, impetigo, septicemia, toxic shock syndrome, flesh-eating disease, rheumatic fever and acute glomerulonephritis. MGAS5005 was isolated in 1996 from the cerebrospinal fluid of an infected patient in Ontario, Canada, and has been used extensively in studies of GAS pathogenesis. (EBI Integr8)
Strain M1 GAS
Complete Yes
Sequencing centre (10-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(25-JUN-2001) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Patient with a wound infection
Isolation country NA
Number of replicons 1
Gram staining properties Positive
Shape Cocci
Mobility No
Flagellar presence No
Number of membranes 1
Oxygen requirements Facultative
Optimal temperature 30.0
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Chains, Pairs
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Wide range of infections
Pathogenicity Yes