Streptococcus sanguinis SK36
Names | Streptococcus sanguinis SK36 |
---|---|
Accession numbers | NC_009009 |
Background | Streptococcus sanguinis, a member of the human indigenous oral microflora, has long been recognized as a key player in the bacterial colonization of the mouth. S. sanguinis directly binds to oral surfaces and serves as a tether for the attachment of a variety of other oral microorganisms which colonize the tooth surface, form dental plaque, and contribute to the etiology of both caries and periodontal disease. Furthermore, S. sanguinis has been long recognized as a leading cause of bacterial endocarditis, a disease of high morbidity which is fatal if untreated. Additionally, S. sanguinis and other viridans streptococci of the mouth are emerging as important bloodstream pathogens in infections which threaten neutropenic patients (patients with decreased numbers of neutrophils in their blood). The reasons underlying this previously unrecognized virulence now elicited by the viridans streptococci are unknown. Such infections are being compounded by the increasing frequency with which penicillin resistance is being observed in this group of organisms. Some of the more central features of S. sanguinis include production of glucans from sucrose, platelet binding, binding to extracellular matrix proteins (e.g., laminin, fibronectin), binding to salivary proteins, ability to specifically co-aggregate with other oral microflora, and genetic competence (adapted from http://www.sanguinis.mic.vcu.edu/background.htm). (EBI Integr8) |
Taxonomy | |
Kingdom: | Bacteria |
Phylum: | Firmicutes |
Class: | Bacilli |
Order: | Lactobacillales |
Family: | Streptococcaceae |
Genus: | Streptococcus |
Species: | sanguinis |
Strain | SK36 |
Complete | Yes |
Sequencing centre | (03-NOV-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA (07-JUN-2006) Virginia Commonwealth University, Philips Institute, Richmond, VA 23298, USA |
Sequencing quality | Level 6: Finished |
Sequencing depth | NA |
Sequencing method | Sanger |
Isolation site | isolated from human dental plaque |
Isolation country | NA |
Number of replicons | 1 |
Gram staining properties | Positive |
Shape | Cocci |
Mobility | No |
Flagellar presence | NA |
Number of membranes | 1 |
Oxygen requirements | Facultative |
Optimal temperature | NA |
Temperature range | Mesophilic |
Habitat | HostAssociated |
Biotic relationship | Free living |
Host name | Homo sapiens |
Cell arrangement | Chains, Pairs |
Sporulation | Nonsporulating |
Metabolism | NA |
Energy source | NA |
Diseases | Endocarditis |
Pathogenicity | Yes |
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Galactose metabolism
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Histidine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Alanine metabolism
Streptomycin biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Pantothenate and CoA biosynthesis
Folate biosynthesis
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Aminoacyl-tRNA biosynthesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Galactose metabolism
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Histidine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Alanine metabolism
Streptomycin biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Pantothenate and CoA biosynthesis
Folate biosynthesis
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Aminoacyl-tRNA biosynthesis