Clostridium novyi NT

Clostridium_novyi
Names Clostridium novyi NT
Accession numbers NC_008593
Background Clostridium novyi-NT, a Gram +, spore-forming bacteria, is an experimentally developed attenuated strain of pathogenic C.novyi. To do so, the major systemic toxin gene-containing episome has been deleted. It was created to be used as an bacteriolytic anti-tumor agent. An anaerobic bacterium is ideally suited as an anti-tumor agent as the only hypoxic regions within mammals are tumors. Intravenous injection of C.novyi-NT spores in rabbits and mice has produced anti-tumor effects without excessive toxicity. While the spores are very stable, the vegetative form is very sensitive to oxygen. (EBI Integr8)
Taxonomy
Kingdom:Bacteria
Phylum:Firmicutes
Class:Clostridia
Order:Clostridiales
Family:Clostridiaceae
Genus:Clostridium
Species:novyi
Strain NT
Complete Yes
Sequencing centre (18-MAY-2006) Howard Hughes Medical Institute and Ludwig Center for Cancer Genetics & Therapeutics at the Johns Hopkins
(29-NOV-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site NA
Isolation country NA
Number of replicons 1
Gram staining properties Positive
Shape Bacilli
Mobility Yes
Flagellar presence NA
Number of membranes 1
Oxygen requirements Anaerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat Terrestrial
Biotic relationship Free living
Host name NA
Cell arrangement Pairs, Singles
Sporulation Sporulating
Metabolism NA
Energy source Chemoorganotroph
Diseases NA
Pathogenicity No