Pasteurella multocida subsp. multocida str. Pm70

Names Pasteurella multocida subsp. multocida str. Pm70
Accession numbers NC_002663
Background Organisms of the genus Pasteurella are Gram-negative, non-motile, facultatively anaerobic coccobacilli belonging to the gamma division of proteobacteria.Pasteurella multocida, named after Louis Pasteur for his early work on attenuated bacteria as vaccines is a multi-species pathogen which causes serious diseases in animals and humans. This bacterium is the causative agent of fowl cholera in chickens and turkeys, hemorrhagic septicemia in cattle, atrophic rhinitis in pigs, and infections in humans from dog and cat bites.This agent is responsible for annual losses of several hundred million dollars to animal production. Furthermore, this pathogen is estimated to infect approximately 20-50% of the 1 to 2 million Americans (primarily children) who are bitten by dogs and cats each year. Patients tend to exhibit swelling, cellulitis and bloody drainage at the wound site. Infection may move to nearby joints where it can cause swelling and arthritis.Researchers have identified two Pm proteins which resemble the filamentous hemagglutinin (fha) genes found in the whooping cough bacterium, Bordella pertussis. These proteins are components of the whooping cough vaccine and may prove useful for preventing infections caused by Pm. The fha proteins help the pertussis bacterium grab onto the host cell, and the Pm versions of these proteins may play similar roles, making them promising vaccine targets.In spite of the important economic impact due to P. multocida infections in food animals and the large numbers of people infected each year worldwide, very little is known about the genetic basis for the virulence of this organism and it still remains unclear how the organism is able to colonize, evade the immune system, and become established in a wide variety of hosts.(From (BacMap)
Strain Pm70
Complete Yes
Sequencing centre (13-SEP-2001) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(25-JUN-2001) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Case of cholera in chickens in 1995
Isolation country NA
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 2
Oxygen requirements Facultative
Optimal temperature 37.0
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Chicken, Homo sapiens
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source NA
Diseases Pasteurellosis
Pathogenicity Yes