Pseudomonas aeruginosa UCBPP-PA14

Pseudomonas_aeruginosa
Names Pseudomonas aeruginosa UCBPP-PA14
Accession numbers NC_008463
Background Pseudomonas aeruginosa is an important soil bacterium, with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. In addition to being able to colonize a wide variety of environments, Pesudomonas aeruginosa is also a pathogen with a wide host range. PA14, a clinical isolate from a human burn patient, has been demonstrated to cause pathogenesis in such diverse hosts as humans, mice, Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. PA14 is also an excellent model for the study of pathogenesis and biofilm formation. Comparison of PA14 with a less pathogenic previously sequenced P.aeruginosa strain (PAO1; PSEAE) showed that genes that are present in PA14 but absent in PAO1 do not correlate with the virulence of these strains. The authors suggest that virulence in P.aeruginoas is the result of the combination of pathogenicity-related genes that interact in different fashions depending on the genetic background (adapted from http://ausubellab.mgh.harvard.edu/cgi-bin/pa14/annotation/start.cgi). (EBI Integr8)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Gammaproteobacteria
Order:Pseudomonadales
Family:Pseudomonadaceae
Genus:Pseudomonas
Species:aeruginosa
Strain UCBPP-PA14
Complete Yes
Sequencing centre (11-OCT-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(18-AUG-2006) Department of Molecular Biology, Massachusetts General Hospital, Richard B. Simches Research Center,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site Human clinical isolate
Isolation country NA
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility Yes
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature 25.0
Temperature range Mesophilic
Habitat Multiple
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Singles
Sporulation Nonsporulating
Metabolism NA
Energy source Heterotroph
Diseases Opportunistic infections
Pathogenicity Yes
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fatty acid metabolism
Synthesis and degradation of ketone bodies
Ubiquinone and other terpenoid-quinone biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine degradation
Geraniol degradation
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Benzoate degradation
Bisphenol degradation
Fluorobenzoate degradation
Phenylalanine, tyrosine and tryptophan biosynthesis
beta-Alanine metabolism
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Alanine metabolism
Glutathione metabolism
Amino sugar and nucleotide sugar metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
Chloroalkane and chloroalkene degradation
Glyoxylate and dicarboxylate metabolism
Nitrotoluene degradation
Propanoate metabolism
Styrene degradation
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Nitrogen metabolism
Sulfur metabolism
Caprolactam degradation
Aminoacyl-tRNA biosynthesis