Granulibacter bethesdensis CGDNIH1

Names Granulibacter bethesdensis CGDNIH1
Accession numbers NC_008343
Background Acetobacteraceae are alphaproteobacteria including the acetic acid bacteria, which incompletely oxidize carbohydrates and alcohols, leading to production of vinegar among other chemicals. They are found worldwide on plant material.G.bethesdensis is a non-motile Gram-negative rod able to growth on methanol as its sole carbon source, and encodes the enzymes necessary for conversion of alcohols to acetic acid making it both an acetic acid bacterium and a methylotroph. Strain CGDNIH1 was identified in excised lymph nodes from a 39 year old male patient with chronic granulomatous disease (CGD), a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections with Staphylococcus aureus, Serratia marcescens, Burkholderia cepacia complex Nocardia and Aspergillus species, and now Granulibacter bethesdensis. This is the first reported case of invasive human disease caused by any of the Acetobacteraceae. It is surrounded by a capsule, which might confer increased resistance. (HAMAP: GRABC)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Alphaproteobacteria
Order:Rhodospirillales
Family:Acetobacteraceae
Genus:Granulibacter
Species:bethesdensis
Strain CGDNIH1
Complete Yes
Sequencing centre (14-SEP-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(21-JUN-2006) Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Disease, The National
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site 39 year old man with Chronic granulomatous disease
Isolation country USA
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 2
Oxygen requirements NA
Optimal temperature NA
Temperature range Mesophilic
Habitat Multiple
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source NA
Diseases Chronic granulomatous disease
Pathogenicity Yes