Granulibacter bethesdensis CGDNIH1
Names | Granulibacter bethesdensis CGDNIH1 |
---|---|
Accession numbers | NC_008343 |
Background | Acetobacteraceae are alphaproteobacteria including the acetic acid bacteria, which incompletely oxidize carbohydrates and alcohols, leading to production of vinegar among other chemicals. They are found worldwide on plant material.G.bethesdensis is a non-motile Gram-negative rod able to growth on methanol as its sole carbon source, and encodes the enzymes necessary for conversion of alcohols to acetic acid making it both an acetic acid bacterium and a methylotroph. Strain CGDNIH1 was identified in excised lymph nodes from a 39 year old male patient with chronic granulomatous disease (CGD), a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections with Staphylococcus aureus, Serratia marcescens, Burkholderia cepacia complex Nocardia and Aspergillus species, and now Granulibacter bethesdensis. This is the first reported case of invasive human disease caused by any of the Acetobacteraceae. It is surrounded by a capsule, which might confer increased resistance. (HAMAP: GRABC) |
Taxonomy | |
Kingdom: | Bacteria |
Phylum: | Proteobacteria |
Class: | Alphaproteobacteria |
Order: | Rhodospirillales |
Family: | Acetobacteraceae |
Genus: | Granulibacter |
Species: | bethesdensis |
Strain | CGDNIH1 |
Complete | Yes |
Sequencing centre | (14-SEP-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA (21-JUN-2006) Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Disease, The National |
Sequencing quality | Level 6: Finished |
Sequencing depth | NA |
Sequencing method | NA |
Isolation site | 39 year old man with Chronic granulomatous disease |
Isolation country | USA |
Number of replicons | 1 |
Gram staining properties | Negative |
Shape | Bacilli |
Mobility | No |
Flagellar presence | No |
Number of membranes | 2 |
Oxygen requirements | NA |
Optimal temperature | NA |
Temperature range | Mesophilic |
Habitat | Multiple |
Biotic relationship | Free living |
Host name | Homo sapiens |
Cell arrangement | NA |
Sporulation | NA |
Metabolism | NA |
Energy source | NA |
Diseases | Chronic granulomatous disease |
Pathogenicity | Yes |
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fatty acid biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Atrazine degradation
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Sulfur metabolism
Aminoacyl-tRNA biosynthesis
Biosynthesis of unsaturated fatty acids
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fatty acid biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Arginine and proline metabolism
Histidine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Selenocompound metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Atrazine degradation
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Sulfur metabolism
Aminoacyl-tRNA biosynthesis
Biosynthesis of unsaturated fatty acids