Methanosphaera stadtmanae DSM 3091

Methanosphaera_stadtmanae
Names Methanosphaera stadtmanae DSM 3091
Accession numbers NC_007681
Background Methanosphaera stadtmanae, the first human archaeal commensal whose genome has been sequenced, thrives in the human intestine, where methanol is a product of pectin degradation by Bacteroides species and other anaerobic bacteria. This human intestinal inhabitant can generate methane only by reduction of methanol with H2 and is dependent on acetate as a carbon source. It has the most restricted energy metabolism of all methanogenic archaea. The genome lacks 37 CDS present in the genomes of all other methanogens. Among these are the CDS for synthesis of molybdopterin (which is required for the enzyme catalyzing the first step of methanogenesis from CO2 + H2) and for synthesis of the CO dehydrogenase/acetyl-coenzyme A synthase complex, which explains why M. stadtmanae cannot reduce CO2 to methane or oxidize methanol to CO2 and why this archaeon is dependent on acetate for biosynthesis of cell components. (HAMAP: METST)
Taxonomy
Kingdom:Archaea
Phylum:Euryarchaeota
Class:Methanobacteria
Order:Methanobacteriales
Family:Methanobacteriaceae
Genus:Methanosphaera
Species:stadtmanae
Strain DSM 3091
Complete Yes
Sequencing centre (05-AUG-2005) Institute of Microbiology and Genetics, Georg August University Goettingen, Goettingen Genomics Laboratory,
(06-JAN-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Human feces
Isolation country NA
Number of replicons 1
Gram staining properties NA
Shape Cocci
Mobility No
Flagellar presence No
Number of membranes 1
Oxygen requirements Anaerobic
Optimal temperature 36.0
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Pairs, Tetrads
Sporulation NA
Metabolism Methanogen
Methanol reducer
Energy source Lithotroph
Diseases NA
Pathogenicity No