Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Staphylococcus_saprophyticus
Names Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
Accession numbers NC_007350, NC_007351, NC_007352
Background Staphylococcus saprophyticus is the frequent cause of uncomplicated urinary tract infections (UTI) in young and middle-aged women. S.saprophyticus (strain ATCC 15305 / DSM 20229) was isolated from a human urine specimen. It harbors 2 plasmids pSSP1 and pSSP2. Its genome contains various mobile genetic elements including one prophage remnant, two IS431 elements, nine putative transposases, two staphylococcal cassettes (SCC), one of which carries a capsular polysaccharide synthesis locus, and one genomic island. The genomic island carries resistance determinants against streptomycin and fosfomycin instead of virulence factors. Genes involved in transport and regulation are abundant whereas there are fewer genes implicated in virulence than in S.aureus and S.epidermidis. Virulence factors such as coagulase, hemolysins, enterotoxins, extracellular matrix-binding proteins are absent. There is a unique cell wall-anchored protein involved in the adherence to uroepithelial cells. There are numerous transporter systems that evolved through paralog expansion. Unlike most uropathogenic bacteria, it has neither siderophores nor alpha-keto acid siderophore-producing systems. However, it possesses homologs of the NRAMP family. It lacks the potassium-importing ATPase. The agr locus, involved in regulation of virulence genes, is suprisingly well conserved conserved despite the absence of typical virulence factors. (EBI Integr8)
Taxonomy
Kingdom:Bacteria
Phylum:Firmicutes
Class:Bacilli
Order:Bacillales
Family:Staphylococcaceae
Genus:Staphylococcus
Species:saprophyticus
Strain ATCC 15305
Complete Yes
Sequencing centre (11-MAR-2005) Masahira Hattori, Kitasato Institute for Life Sciences
(20-AUG-2005) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
1-15-1 Kitasato, Sagamihara, Kanagawa, 228-0829,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Human urine specimen
Isolation country NA
Number of replicons 3
Gram staining properties Positive
Shape Cocci
Mobility No
Flagellar presence No
Number of membranes 1
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement Clusters, Singles
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Urinary tract infections
Pathogenicity Yes