Burkholderia pseudomallei K96243

Burkholderia_pseudomallei
Names Burkholderia pseudomallei K96243
Accession numbers NC_006350, NC_006351
Background Burkholderia pseudomallei strain K96243. This strain was a clinical isolate from Thailand. The genome of this organism carries many genomic islands as compared to the related organism B. mallei, suggesting extensive horizontal transfer. Three different type III secretion systems (TTSS) are encoded on the chromosomes of this organism, two of which are similar to plant pathogenic TTSSs, while the third is similar to the Salmonella pathogenicity island, all of which may contribute to pathogenicity. Other virulence determinants include multidrug efflux pumps, secreted toxins and proteases, and various adhesins. Capsular polysaccharide may protect the organism from host defense mechanisms. This organism also carries a number of small sequence repeats which may promoter antigenic variation, similar to what was found with the B. mallei genome. (NCBI BioProject: bp_list[1])
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Betaproteobacteria
Order:Burkholderiales
Family:Burkholderiaceae
Genus:Burkholderia
Species:pseudomallei
Strain K96243
Complete Yes
Sequencing centre (01-OCT-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(01-SEP-2004) Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site Clinical isolate from Thailand
Isolation country Thailand
Number of replicons 2
Gram staining properties Negative
Shape Bacilli
Mobility Yes
Flagellar presence Yes
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat Terrestrial
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source NA
Diseases Melioidosis
Pathogenicity Yes
Glycolysis / Gluconeogenesis
Citrate cycle (TCA cycle)
Pentose phosphate pathway
Fructose and mannose metabolism
Galactose metabolism
Fatty acid metabolism
Synthesis and degradation of ketone bodies
Ubiquinone and other terpenoid-quinone biosynthesis
Purine metabolism
Pyrimidine metabolism
Alanine, aspartate and glutamate metabolism
Glycine, serine and threonine metabolism
Cysteine and methionine metabolism
Valine, leucine and isoleucine degradation
Geraniol degradation
Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis
Lysine degradation
Arginine and proline metabolism
Histidine metabolism
Phenylalanine metabolism
Benzoate degradation
Bisphenol degradation
Fluorobenzoate degradation
Phenylalanine, tyrosine and tryptophan biosynthesis
beta-Alanine metabolism
Taurine and hypotaurine metabolism
Selenocompound metabolism
Cyanoamino acid metabolism
D-Glutamine and D-glutamate metabolism
D-Arginine and D-ornithine metabolism
D-Alanine metabolism
Glutathione metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Streptomycin biosynthesis
Lipopolysaccharide biosynthesis
Peptidoglycan biosynthesis
Pyruvate metabolism
Toluene degradation
Chloroalkane and chloroalkene degradation
Naphthalene degradation
Glyoxylate and dicarboxylate metabolism
Propanoate metabolism
Ethylbenzene degradation
Styrene degradation
Butanoate metabolism
C5-Branched dibasic acid metabolism
One carbon pool by folate
Thiamine metabolism
Riboflavin metabolism
Vitamin B6 metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Biotin metabolism
Lipoic acid metabolism
Folate biosynthesis
Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis
Nitrogen metabolism
Sulfur metabolism
Caprolactam degradation
Aminoacyl-tRNA biosynthesis
Biosynthesis of unsaturated fatty acids