Porphyromonas gingivalis TDC60

Porphyromonas_gingivalis
Names Porphyromonas gingivalis TDC60
Accession numbers NC_015571
Background Porphyromonas gingivalis is a Gram-negative anaerobe. It is a secondary colonizer of the oral cavity and has a role in the initiation and progression of periodontal disease, which is the major cause of tooth loss in industrial nations. It is a chronic inflammatory disease of the periodontium that leads to erosion of the attachment apparatus and supporting bone for teeth and is one of the most frequently occurring infectious diseases in humans. Recently, a number of epidemiological studies have shown significant relationships between periodontal diseases and cardiovascular diseases. P.gingivalis, which is often found in deep periodontal pockets of humans, is asaccharolytic and highly proteolytic and produces a broad array of potential virulence factors involved in tissue colonization and destruction as well as host defense perturbation. P. gingivalis strains are divided into virulent and less-virulent strans; ATCC 33277, the type strain, is a less-virulent strain unlike W83, the only other currently sequenced member of the species (PORGI). It produces only a localized abscess 3 days after subcutaneous inoculation (adapted from PubMed 18524787). (HAMAP: PORG3)
Taxonomy
Kingdom:Bacteria
Phylum:Bacteroidetes
Class:Bacteroidia
Order:Bacteroidales
Family:Porphyromonadaceae
Genus:Porphyromonas
Species:gingivalis
Strain TDC60
Complete Yes
Sequencing centre (19-MAY-2011) Contact:Ichiro Nakagawa Tokyo Medical and Dental University
(24-MAY-2011) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8510, Japan
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method 454, Sanger
Isolation site severe periodontal lesion at Tokyo Dental College in Japan
Isolation country Japan
Number of replicons 1
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence NA
Number of membranes 2
Oxygen requirements Anaerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement NA
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases NA
Pathogenicity Yes