Bifidobacterium bifidum PRL2010

Names Bifidobacterium bifidum PRL2010
Accession numbers NC_014638
Background Bifidobacteria represent an important group of the intestinal microbiota of humans and are believed to be promising candidates for pharmaceutical applications and functional food products due to their ability to exclude intestinal pathogens, strengthen the intestinal barrier, and/or modulate the immune response in the intestine. Bifidobacterium bifidum (strain PRL2010) is a anaerobic Gram-positive bacterium isolated from infant stool and is used as a probiotic to maintain healthy gut flora. It revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology. (Adapted from PMID: 20974960). (EBI Integr8)
Strain PRL2010
Complete Yes
Sequencing centre (02-NOV-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(12-NOV-2009) Department of Genetics, Biology of Microorganisms, Anthropology and Evolution, University of Parma,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method 454-GS-FLX
Isolation site human feces in Korea
Isolation country Korea
Number of replicons 1
Gram staining properties Positive
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 1
Oxygen requirements Anaerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement NA
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases NA
Pathogenicity No