Brachyspira pilosicoli 95/1000

Names Brachyspira pilosicoli 95/1000
Accession numbers NC_014330
Background Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000) is an anaerobic Gram-negative bacterium which colonizes the large intestine of various species of birds and mammals, including humans. It causes "intestinal spirochetosis", a condition characterized by mild colitis, diarrhea and reduced growth. The three Brachyspira species shared 1,087 genes and showed evidence of extensive genome rearrangements. Despite minor differences in predicted protein functional groups, the species had many similar features including core metabolic pathways. Genes distinguishing B. pilosicoli from B. hyodysenteriae included those for a previously undescribed bacteriophage that may be useful for genetic manipulation, for a glycine reductase complex allowing use of glycine whilst protecting from oxidative stress, and for aconitase and related enzymes in the incomplete TCA cycle, allowing glutamate synthesis and function of the cycle during oxidative stress. B. pilosicoli had substantially fewer methyl-accepting chemotaxis genes than B. hyodysenteriae and hence these species are likely to have different chemotactic responses that may help to explain their different host range and colonization sites. B. pilosicoli lacked the gene for a new putative hemolysin identified in B. hyodysenteriae WA1. (adapted from PMID: 20625514). (EBI Integr8)
Strain 95/1000
Complete Yes
Sequencing centre (16-JUL-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(28-APR-2010) Centre for Comparative Genomics, Murdoch University, South Str., Perth, Western Australia 6150, Australia
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site diarrheic feces of animal with intestinal spirochetosis
Isolation country Australia
Number of replicons 1
Gram staining properties Negative
Shape Spirilla
Mobility No
Flagellar presence No
Number of membranes 2
Oxygen requirements Anaerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Symbiotic
Host name Sus scrofa
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source Chemoorganotroph
Diseases intestinal spirochetosis
Pathogenicity Yes