Helicobacter mustelae 12198

Helicobacter_mustelae
Names Helicobacter mustelae 12198
Accession numbers NC_013949
Background Helicobacter mustelae is a gastric pathogen of ferrets (Mustela putorius), and was the second member of the genus identified. H. mustelae cells are smaller and typically less helical than those of H. pylori, with lateral as well as bipolar flagella. H. mustelae is virtually endemic in ferrets and other mustelids, and like H. pylori, stimulates a humoral immune response which does not clear the infection. Experimentally infected ferrets develop a gastritis which closely resembles the diffuse antral gastritis seen in some adults, and in children. Ferret gastric epithelial cell proliferation increases upon H. mustelae infection, and the bacterium has been linked to gastric adenocarcinoma and MALT lymphoma in the infected ferret. Ulcer formation in H. mustelae-infected ferrets is also common; H. mustelae infection of ferrets is the only natural model of Helicobacter-associated ulcer disease, making it a unique model. Thus the knowledge base and tractability of the ferret makes it an attractive animal model for human gastric disease due to Helicobacter infection (adapted from PMID 20219135). (HAMAP: HELM1)
Taxonomy
Kingdom:Bacteria
Phylum:Proteobacteria
Class:Epsilonproteobacteria
Order:Campylobacterales
Family:Helicobacteraceae
Genus:Helicobacter
Species:mustelae
Strain 12198
Complete Yes
Sequencing centre (18-MAR-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(18-SEP-2009) Bentley S.D., Pathogen Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site Gastric mucosa of a ferret
Isolation country NA
Number of replicons 1
Gram staining properties Negative
Shape Spirilla
Mobility Yes
Flagellar presence No
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens, Mustela putorius furo
Cell arrangement Singles
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases NA
Pathogenicity NA