Citrobacter rodentium ICC168

Names Citrobacter rodentium ICC168
Accession numbers NC_013716, NC_013717, NC_013718, NC_013719
Background Citrobacter rodentium is a close relative of Escherichia coli transmitted via the fecal-oral route. C.rodentium is a highly infectious natural mouse pathogen that is used as a model system to study the pathogenic mechanisms of enteropathogenic and enterohaemorrhagic E. coli. It causes colitis and transmissible colonic hyperplasia in mice. Following ingestion, it colonizes the intestines of mice, residing predominantly in the cecum and colon, where in some inbred strains it can drive hyperplasia or overgrowth of the epithelium. It is an extracellular pathogen, and forms attaching/effacing (A/E) lesions on the apical surfaces of enterocytes. A/E lesions, which are characterized by effacement of the brush border microvilli and intimate bacterial attachment to pedestal-like structures, are also classically associated with the pathogenesis of enteropathogenic E. coli (EPEC) and enterohemorrhagic E.coli (EHEC). In this respect, C.rodentium, EPEC, and EHEC share a common virulence strategy.This strain has a single chromosome and 4 plasmids, only 3 of which were submitted with the genome project. The other is identical to plasmid pCRP3, sequenced from Citrobacter rodentium strain DBS100 and available under the nucleotide accession number AF311902 (adapted from PMID 19897651). (HAMAP: CITRI)
Strain ICC168
Complete Yes
Sequencing centre (07-JAN-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(19-AUG-2009) Petty N.K., Pathogen Genomics, Sanger Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SA,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method Sanger
Isolation site NA
Isolation country NA
Number of replicons 4
Gram staining properties Negative
Shape Bacilli
Mobility No
Flagellar presence NA
Number of membranes 2
Oxygen requirements Facultative
Optimal temperature NA
Temperature range Mesophilic
Habitat Multiple
Biotic relationship Free living
Host name NA
Cell arrangement NA
Sporulation NA
Metabolism NA
Energy source NA
Diseases Murine colonic hyperplasia
Pathogenicity NA