Bifidobacterium dentium Bd1

Names Bifidobacterium dentium Bd1
Accession numbers NC_013714
Background Among the members of the large, diverse, and dynamic microbial community residing in the human gastrointestinal tract (GIT), Bifidobacterium is a dominant genus considered beneficial to humans. The GIT of healthy newborns is typically colonized by bifidobacteria, especially in breast-fed infants, during the first few days of life. However among Bifidobacterium is also found Bifdobacterium dentium, an opportunistic cariogenic pathogen. The genetic basis for the ability of B. dentium to survive in the oral cavity and contribute to caries development is not understood. Annotation of the genome sequence revealed multiple ways in which B. dentium has adapted to the oral environment through specialized nutrient acquisition, defense against antimicrobial agents, and gene products that increase fitness and competitiveness within the oral niche. B. dentium Bd1 was shown to metabolize a wide variety of carbohydrates, while colonization and persistence factors implicated in tissue adhesion, acid tolerance, and the metabolism of human saliva-derived compounds were also identified. It has evolved through a very limited number of horizontal gene acquisition events (adapted from PMID 20041198). (EBI Integr8)
Strain Bd1
Complete Yes
Sequencing centre (06-JAN-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
(30-JUL-2009) Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National
(30-JUL-2009) Department of Genetics, Biology of Microorganisms, Anthropology and Evolution, University of Parma,
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method NA
Isolation site dental caries
Isolation country NA
Number of replicons 1
Gram staining properties Positive
Shape Bacilli
Mobility No
Flagellar presence No
Number of membranes 1
Oxygen requirements Anaerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship Free living
Host name Homo sapiens
Cell arrangement NA
Sporulation Nonsporulating
Metabolism NA
Energy source NA
Diseases Dental caries
Pathogenicity Yes