Anaplasma centrale str. Israel

Names Anaplasma centrale str. Israel
Accession numbers NC_013532
Background Anaplasma marginale is the most prevalent tick-borne pathogen of cattle. It is transmitted by ixodid ticks. Symptoms of acute disease are anemia, weight loss, and often death. A.marginale establishes life-long persistent infection in animals that survive disease. These animals are clinically healthy but serve as reservoirs for transmission of the pathogen. Anaplasma marginale subsp. centrale (Anaplasma centrale (strain Israel)) is a naturally occurring attenuated strain has been used as a live vaccine to prevent severe disease due to A. marginale senso stricto strains for 100 years. A. marginale subsp. centrale contains 10 putative genes not found in the genomes of senso stricto strains, while 18 genes found in senso stricto strains are absent from A. marginale subsp. centrale. As inoculation with purified outer membrane protein (OMP) complexes provides immunity against A. marginale, it is important to identify OMPs that differ among A,marginale to identify further vaccine candidates. Comparative analysis reduces the number of candidate proteins to six: four Msp2 superfamily members (Msp4, Omp1, Omp7, and OpAG2) and two non-superfamily members (AM779/ACIS557 and AM854/ACIS486) (adapted from PMID 19854912). (HAMAP: ANACI)
Strain Israel
Complete Yes
Sequencing centre (24-SEP-2009) Animal Disease Research Unit, United States Department of Agriculture - Agriculture Research Service, 3003
(26-NOV-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Sequencing quality Level 6: Finished
Sequencing depth NA
Sequencing method WGS
Isolation site NA
Isolation country South Africa
Number of replicons 1
Gram staining properties Negative
Shape Cocci
Mobility No
Flagellar presence No
Number of membranes 2
Oxygen requirements Aerobic
Optimal temperature NA
Temperature range Mesophilic
Habitat HostAssociated
Biotic relationship NA
Host name NA
Cell arrangement Singles
Sporulation NA
Metabolism NA
Energy source NA
Diseases Anaplasmosis
Pathogenicity No