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The map label for this gene is fabD [H]

Identifier: 99080891

GI number: 99080891

Start: 1129265

End: 1130200

Strand: Direct

Name: fabD [H]

Synonym: TM1040_1050

Alternate gene names: 99080891

Gene position: 1129265-1130200 (Clockwise)

Preceding gene: 99080889

Following gene: 99080892

Centisome position: 35.28

GC content: 66.45

Gene sequence:

>936_bases
ATGTCGATCGCTTTTGTTTTCCCCGGCCAGGGGGCTCAGACCATCGGAATGGGCAAAGCGCTGGCGGAGGCTTATCCGGC
CGCCAAAGCCGTGTTCAACGAGGTGGACGAGGCCCTCGGAGAGAGCCTGAGCCACCTGATCTGGGAGGGCGACATCGAGA
CCTTGACCCTGACGCAGAACGCTCAGCCGGCGTTGATGGCGACCTCCATGGCGGCAATGCGCGCGCTGGAGGCAGAGGGC
GTCAGCATCGACAAGGCCGCCTTTGTGGCCGGGCACTCCTTGGGGGAATATTCCGCGCTGGCGGCAGCCGGTGCGCTCTC
GATCGCCGACACCGCTCGCCTGCTGCGCACTCGAGGGCAGGCGATGCAAAGCGCCGTGCCGGTGGGTGTCGGTGCGATGG
CCGCGCTTCTCGGGCTTGATTTTGAAACCGTAAAAGCCGTGGCCGCCGAGGCCGCAGCCGAGGGCGAGGTGGTGCAGGCC
GCAAATGACAATGACCCGACGCAGGTGGTGGTCTCCGGCCACAAGGCCGCGGTAGAGCGCGCCGCCGAGATCGCCAAGGA
AAAAGGCGCCAAACGCGCGGTGATGCTGCCGGTCTCCGCCCCCTTCCACTGTGCCCTGATGCAGCCCGCCGCCGATGTGA
TGGCCGAGGCACTTGCAGGCGTGGAAATCAAGGCGCCTGCGGTGCCGCTGATCGCCAATGTGCGCGCCGATGCGGTCACC
GACCCCGACACCATCCGCGCCCTTTTGGTGGAGCAGGTCACAGGGTCGGTGCGCTGGCGCGAGAGCGTCGCGGCGATGGC
GGCCAAGGGCGTCACAGAGTTCTGGGAGATCGGCGCGGGCAAGGCGCTTTCGGGTATGATCCGCAAGATCGACCGTTCCC
TGGTCTCAAAACAGGTCGGCACCGACGCTGACGTCAAAGCCGTGACCGGCGCATAA

Upstream 100 bases:

>100_bases
AGGTGTGCGCTCTGGAACTCTCGCACTCGTGAAATGCTTGTGTGCCTTCCCTTGGGTCGCTAAACCAGCCCGAAAGACAG
TTTTAGGAATGAGGACAGCC

Downstream 100 bases:

>100_bases
TCCATAAGGAAGAGACAAAGATGTTTGATCTGACAGGTAAGAACGCGCTGATCACAGGCGCATCCGGTGGCATCGGTGGC
GACATTGCGCGCGCGCTCCA

Product: [Acyl-carrier-protein] S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSIAFVFPGQGAQTIGMGKALAEAYPAAKAVFNEVDEALGESLSHLIWEGDIETLTLTQNAQPALMATSMAAMRALEAEG
VSIDKAAFVAGHSLGEYSALAAAGALSIADTARLLRTRGQAMQSAVPVGVGAMAALLGLDFETVKAVAAEAAAEGEVVQA
ANDNDPTQVVVSGHKAAVERAAEIAKEKGAKRAVMLPVSAPFHCALMQPAADVMAEALAGVEIKAPAVPLIANVRADAVT
DPDTIRALLVEQVTGSVRWRESVAAMAAKGVTEFWEIGAGKALSGMIRKIDRSLVSKQVGTDADVKAVTGA

Sequences:

>Translated_311_residues
MSIAFVFPGQGAQTIGMGKALAEAYPAAKAVFNEVDEALGESLSHLIWEGDIETLTLTQNAQPALMATSMAAMRALEAEG
VSIDKAAFVAGHSLGEYSALAAAGALSIADTARLLRTRGQAMQSAVPVGVGAMAALLGLDFETVKAVAAEAAAEGEVVQA
ANDNDPTQVVVSGHKAAVERAAEIAKEKGAKRAVMLPVSAPFHCALMQPAADVMAEALAGVEIKAPAVPLIANVRADAVT
DPDTIRALLVEQVTGSVRWRESVAAMAAKGVTEFWEIGAGKALSGMIRKIDRSLVSKQVGTDADVKAVTGA
>Mature_310_residues
SIAFVFPGQGAQTIGMGKALAEAYPAAKAVFNEVDEALGESLSHLIWEGDIETLTLTQNAQPALMATSMAAMRALEAEGV
SIDKAAFVAGHSLGEYSALAAAGALSIADTARLLRTRGQAMQSAVPVGVGAMAALLGLDFETVKAVAAEAAAEGEVVQAA
NDNDPTQVVVSGHKAAVERAAEIAKEKGAKRAVMLPVSAPFHCALMQPAADVMAEALAGVEIKAPAVPLIANVRADAVTD
PDTIRALLVEQVTGSVRWRESVAAMAAKGVTEFWEIGAGKALSGMIRKIDRSLVSKQVGTDADVKAVTGA

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=302, Percent_Identity=32.4503311258278, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI27477045, Length=107, Percent_Identity=38.3177570093458, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787334, Length=293, Percent_Identity=49.8293515358362, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71984332, Length=293, Percent_Identity=30.3754266211604, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=296, Percent_Identity=28.7162162162162, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24665753, Length=298, Percent_Identity=33.2214765100671, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 31857; Mature: 31726

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAFVFPGQGAQTIGMGKALAEAYPAAKAVFNEVDEALGESLSHLIWEGDIETLTLTQN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
AQPALMATSMAAMRALEAEGVSIDKAAFVAGHSLGEYSALAAAGALSIADTARLLRTRGQ
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AMQSAVPVGVGAMAALLGLDFETVKAVAAEAAAEGEVVQAANDNDPTQVVVSGHKAAVER
HHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEECCHHHHHHH
AAEIAKEKGAKRAVMLPVSAPFHCALMQPAADVMAEALAGVEIKAPAVPLIANVRADAVT
HHHHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHHHHHCCCEECCCCCCHHCCCCCCCCC
DPDTIRALLVEQVTGSVRWRESVAAMAAKGVTEFWEIGAGKALSGMIRKIDRSLVSKQVG
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
TDADVKAVTGA
CCCCCEECCCC
>Mature Secondary Structure 
SIAFVFPGQGAQTIGMGKALAEAYPAAKAVFNEVDEALGESLSHLIWEGDIETLTLTQN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
AQPALMATSMAAMRALEAEGVSIDKAAFVAGHSLGEYSALAAAGALSIADTARLLRTRGQ
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AMQSAVPVGVGAMAALLGLDFETVKAVAAEAAAEGEVVQAANDNDPTQVVVSGHKAAVER
HHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEECCHHHHHHH
AAEIAKEKGAKRAVMLPVSAPFHCALMQPAADVMAEALAGVEIKAPAVPLIANVRADAVT
HHHHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHHHHHCCCEECCCCCCHHCCCCCCCCC
DPDTIRALLVEQVTGSVRWRESVAAMAAKGVTEFWEIGAGKALSGMIRKIDRSLVSKQVG
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
TDADVKAVTGA
CCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]