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The map label for this gene is htrB [C]

Identifier: 99080849

GI number: 99080849

Start: 1079214

End: 1080134

Strand: Reverse

Name: htrB [C]

Synonym: TM1040_1008

Alternate gene names: 99080849

Gene position: 1080134-1079214 (Counterclockwise)

Preceding gene: 99080850

Following gene: 99080847

Centisome position: 33.74

GC content: 60.04

Gene sequence:

>921_bases
ATGCCCGTAGCTCAGTCGGAGCTGGTTTTTTCTCAGCGTGCAAAATACTTTGCCAGCAACCTTGTGCTGCGCGCCCTGAT
CGGCGGGCTAAAGCTCATCCCTTATCGCTGGCGCGTGCCTTCCATGGGCTGGATCCTGCGCATGCTGGCACCCTTGGTGG
GGTTCCACAAACGCGTGCGCCGGAACCTCGAATATACCCGCCCGGACCTGAGCAACGCCGAGGTGAACCGGCTCTGTCAT
GAGGTGGCCGACAACGTGGGGCGCACCCTCGCCGAACTTTATGCAGGCAAACCTTTCTGGGCCCGCGCAAACGCCGCAGA
CATCAGCGGCCCCGGTCTAGAAGCCTTGAAGCGCGCGCAGGCCGAAGGTCGCCCGGTGATCCTGGTGACAGGCCATTTTG
GCAATTATGACGCCGCGCGTTCAAAGCTGGTGCAGATGGGCTTTAATATGGGATCGCTCTATCGGCGCATGGCCAATCCC
TATTTCAACGAACACTACGTCAAAGCGATCTCGGCCACCGGCAAGCCCATGTTTGAACAGGGAAAGCGCGGGATGGTCGA
AATGGTGCGTCACCTGAAAGCCGGGGGCAATATTGCAATTGTCGCGGATATGCACGCGATGGGCGGGACCTATCTGCCCT
TCTTCGGTCGCCCGGCCCTGACCTCCACCGTACCGGCGGAGCTTGCGTTGAAATACAAGGCCGCCTTCATCCCGATCTAC
GGCATCAGGCGCGAAAACGGGATGGATTTTGACGTGGTTGTGGCCGAAGAGATCGCCCATTCAGACCCGGTGACCATGAC
CCAGGCGGTCTGCGATGATCTGGAGCAGCGCATTCGCGCCCATATGGGTCAGTGGTTTTGGCTGCACCGGCGCTGGAAGC
CGATGCATGACACACCACACCCGGATTACCCGAAGCGCTGA

Upstream 100 bases:

>100_bases
CCCCGGTGGCGCGGGTTTCTCTTTTGCGCTTTCTTGTGCATCCCGGCGCAGCTCAGTATGATCCGGCCTTGCAATCCCTC
CAGCAGGAGCCCCAACCCAG

Downstream 100 bases:

>100_bases
GGGTCACTCCACCCGTGCGGCCGCAAAAATTGGGCCGAAGGGCCATTCCTGCACCAACACCGCCGCCGGAAGTTCCCCCG
CAAAGCTTGCTGTGACCTCG

Product: lipid A biosynthesis acyltransferase

Products: KDO2-(lauroyl)-lipid IVA [C]

Alternate protein names: Lipid A Biosynthesis Acyltransferase; Lauroyl/Myristoyl Acyltransferase; Acyltransferase; Acyltransferase HtrB Family; Bacterial Lipid A Biosynthesis Acyltransferase Superfamily; Lauroyl Acyltransferase; Bacterial Lipid A Biosynthesis Acyltransferase; Lipid A Biosynthesis Lauroyl/Myristoyl Acyltransferase; Lipid A Biosynthesis Lauroyl Acyltransferase Subfamily; Lipid A Biosynthesis Lauroyl Acyltransferase Protein; Lipid A Biosynthesis Acyltransferase Family; Lipid A Lauroyl Acyltransferase Protein; Decanoyltransferase LpxX

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MPVAQSELVFSQRAKYFASNLVLRALIGGLKLIPYRWRVPSMGWILRMLAPLVGFHKRVRRNLEYTRPDLSNAEVNRLCH
EVADNVGRTLAELYAGKPFWARANAADISGPGLEALKRAQAEGRPVILVTGHFGNYDAARSKLVQMGFNMGSLYRRMANP
YFNEHYVKAISATGKPMFEQGKRGMVEMVRHLKAGGNIAIVADMHAMGGTYLPFFGRPALTSTVPAELALKYKAAFIPIY
GIRRENGMDFDVVVAEEIAHSDPVTMTQAVCDDLEQRIRAHMGQWFWLHRRWKPMHDTPHPDYPKR

Sequences:

>Translated_306_residues
MPVAQSELVFSQRAKYFASNLVLRALIGGLKLIPYRWRVPSMGWILRMLAPLVGFHKRVRRNLEYTRPDLSNAEVNRLCH
EVADNVGRTLAELYAGKPFWARANAADISGPGLEALKRAQAEGRPVILVTGHFGNYDAARSKLVQMGFNMGSLYRRMANP
YFNEHYVKAISATGKPMFEQGKRGMVEMVRHLKAGGNIAIVADMHAMGGTYLPFFGRPALTSTVPAELALKYKAAFIPIY
GIRRENGMDFDVVVAEEIAHSDPVTMTQAVCDDLEQRIRAHMGQWFWLHRRWKPMHDTPHPDYPKR
>Mature_305_residues
PVAQSELVFSQRAKYFASNLVLRALIGGLKLIPYRWRVPSMGWILRMLAPLVGFHKRVRRNLEYTRPDLSNAEVNRLCHE
VADNVGRTLAELYAGKPFWARANAADISGPGLEALKRAQAEGRPVILVTGHFGNYDAARSKLVQMGFNMGSLYRRMANPY
FNEHYVKAISATGKPMFEQGKRGMVEMVRHLKAGGNIAIVADMHAMGGTYLPFFGRPALTSTVPAELALKYKAAFIPIYG
IRRENGMDFDVVVAEEIAHSDPVTMTQAVCDDLEQRIRAHMGQWFWLHRRWKPMHDTPHPDYPKR

Specific function: Acylates The Intermediate (Kdo)2-Lipid IVa To Form (Kdo)2-(Lauroyl)-Lipid IVa. Has 10 Fold Selectivity For Lauroyl- Acp Over Myristoyl-Acp. [C]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.- [C]

Molecular weight: Translated: 34608; Mature: 34476

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAQSELVFSQRAKYFASNLVLRALIGGLKLIPYRWRVPSMGWILRMLAPLVGFHKRVR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEECCCCCHHHHHHHHHHHHHHHHHHH
RNLEYTRPDLSNAEVNRLCHEVADNVGRTLAELYAGKPFWARANAADISGPGLEALKRAQ
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHH
AEGRPVILVTGHFGNYDAARSKLVQMGFNMGSLYRRMANPYFNEHYVKAISATGKPMFEQ
CCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHH
GKRGMVEMVRHLKAGGNIAIVADMHAMGGTYLPFFGRPALTSTVPAELALKYKAAFIPIY
CCCCHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEE
GIRRENGMDFDVVVAEEIAHSDPVTMTQAVCDDLEQRIRAHMGQWFWLHRRWKPMHDTPH
EEECCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PDYPKR
CCCCCC
>Mature Secondary Structure 
PVAQSELVFSQRAKYFASNLVLRALIGGLKLIPYRWRVPSMGWILRMLAPLVGFHKRVR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEECCCCCHHHHHHHHHHHHHHHHHHH
RNLEYTRPDLSNAEVNRLCHEVADNVGRTLAELYAGKPFWARANAADISGPGLEALKRAQ
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHH
AEGRPVILVTGHFGNYDAARSKLVQMGFNMGSLYRRMANPYFNEHYVKAISATGKPMFEQ
CCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHH
GKRGMVEMVRHLKAGGNIAIVADMHAMGGTYLPFFGRPALTSTVPAELALKYKAAFIPIY
CCCCHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEE
GIRRENGMDFDVVVAEEIAHSDPVTMTQAVCDDLEQRIRAHMGQWFWLHRRWKPMHDTPH
EEECCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PDYPKR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; lauroyl-ACP [C]

Specific reaction: KDO2-lipid IVA + lauroyl-ACP = KDO2-(lauroyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: Acyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA