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The map label for this gene is moaA [H]

Identifier: 99080565

GI number: 99080565

Start: 781420

End: 782427

Strand: Reverse

Name: moaA [H]

Synonym: TM1040_0724

Alternate gene names: 99080565

Gene position: 782427-781420 (Counterclockwise)

Preceding gene: 99080567

Following gene: 99080564

Centisome position: 24.44

GC content: 59.82

Gene sequence:

>1008_bases
ATGACAGCACCTTTGATTGATCCCTTCGCGCGCGCGATCACCTATCTTCGGGTCTCGGTTACGGACCGTTGCGATTTTCG
CTGCGTTTATTGCATGTCCGAGAACATGACCTTCCTGCCGAAGAAGGAGCTTTTGACGCTCGAGGAGCTCGATCGCATGT
GTTCCACCTTCGTGCGACTGGGCGTTGAAAAACTGCGTATCACCGGAGGAGAGCCTCTGGTGCGCCGTGACATCATGACG
TTTTTCCGCTCGATGACGCGGCATCTGGACAGCGGCGCCCTTAAGGAGCTGACGCTGACCACCAATGGCTCGCAACTCGA
AAAACATGCACAGGCGCTCTATGACGCCGGGGTGCGGCGGGTGAATGTGTCACTGGACACGCTCGACGAGAAGAAATTCG
CAGACGTCACCCGCTGGGGCCGCCTGCCGCAAGTGCTGCGCGGGATCGATGCGGCGCAGGCCGCGGGCCTCAAAATCAAA
ATCAACGCGGTTGCGCTCAAGGGCTTTAACGAGGACGAGCTGTTCTCCATGACCCAGTGGTGCGCAGATCGCGGCATCGA
CCTCACCTGGATCGAAGTCATGCCGATGGGCGACATCGGAAACGAGAGCCGTCTGGGCCAATACTGGTCCCTCAAAGACG
TGCGCAAAGCCTACGAGAGCGGTTATCAGGTCACCGACCTGGCGGAACGCACAGGCGGGCCTGCGCGCTATGTGCGGCTT
GAGGAAACCGGCCAAAAGATCGGTTTTATCACGCCCCTTAGCCATAATTTCTGCGAAAGCTGCAACCGCGTGCGCCTCAC
CTGCACAGGGGAGCTTTATATGTGCCTTGGCCAAGAGGACATGGCTGATCTGCGCGCGCCGCTGCGCGATCATCCCGACA
CCGAGGCGCCCCTCGAAGAAGCCATTCGCGCGGCCATCAACCTCAAGCCCAAAGGGCATGATTTTGACTACTCCCGCCAG
ACCGTCGACGGCCAGATGCCGCGCCACATGAGCCACACCGGCGGGTAA

Upstream 100 bases:

>100_bases
AGACCCTAGCCCGACCTCATGGGGGATGCCAGCCACAAAGCTGGATTTGCTGCATAAGCTCCTATTGTCCTGAGCGATTT
CCCGCCTTACCTATAGTTTT

Downstream 100 bases:

>100_bases
GGCTCCAGACGATGACCGATCCATCGCAGGTCGCCCCGACCCTGCTCTATCACCTCTATCGCGGTGCCAGCACGCTCTTG
GCGCCGCTGATGTGGTCCAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVRLGVEKLRITGGEPLVRRDIMT
FFRSMTRHLDSGALKELTLTTNGSQLEKHAQALYDAGVRRVNVSLDTLDEKKFADVTRWGRLPQVLRGIDAAQAAGLKIK
INAVALKGFNEDELFSMTQWCADRGIDLTWIEVMPMGDIGNESRLGQYWSLKDVRKAYESGYQVTDLAERTGGPARYVRL
EETGQKIGFITPLSHNFCESCNRVRLTCTGELYMCLGQEDMADLRAPLRDHPDTEAPLEEAIRAAINLKPKGHDFDYSRQ
TVDGQMPRHMSHTGG

Sequences:

>Translated_335_residues
MTAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVRLGVEKLRITGGEPLVRRDIMT
FFRSMTRHLDSGALKELTLTTNGSQLEKHAQALYDAGVRRVNVSLDTLDEKKFADVTRWGRLPQVLRGIDAAQAAGLKIK
INAVALKGFNEDELFSMTQWCADRGIDLTWIEVMPMGDIGNESRLGQYWSLKDVRKAYESGYQVTDLAERTGGPARYVRL
EETGQKIGFITPLSHNFCESCNRVRLTCTGELYMCLGQEDMADLRAPLRDHPDTEAPLEEAIRAAINLKPKGHDFDYSRQ
TVDGQMPRHMSHTGG
>Mature_334_residues
TAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVRLGVEKLRITGGEPLVRRDIMTF
FRSMTRHLDSGALKELTLTTNGSQLEKHAQALYDAGVRRVNVSLDTLDEKKFADVTRWGRLPQVLRGIDAAQAAGLKIKI
NAVALKGFNEDELFSMTQWCADRGIDLTWIEVMPMGDIGNESRLGQYWSLKDVRKAYESGYQVTDLAERTGGPARYVRLE
ETGQKIGFITPLSHNFCESCNRVRLTCTGELYMCLGQEDMADLRAPLRDHPDTEAPLEEAIRAAINLKPKGHDFDYSRQT
VDGQMPRHMSHTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=325, Percent_Identity=34.1538461538462, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI22027536, Length=325, Percent_Identity=34.1538461538462, Blast_Score=178, Evalue=5e-45,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=35.5029585798817, Blast_Score=205, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=313, Percent_Identity=35.4632587859425, Blast_Score=203, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI32566329, Length=313, Percent_Identity=35.4632587859425, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17561210, Length=313, Percent_Identity=34.8242811501597, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI28574490, Length=316, Percent_Identity=37.0253164556962, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574488, Length=316, Percent_Identity=37.0253164556962, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37883; Mature: 37752

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVRL
CCCCCHHHHHHHHHHHEEEECCCCCCEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHHH
GVEKLRITGGEPLVRRDIMTFFRSMTRHLDSGALKELTLTTNGSQLEKHAQALYDAGVRR
CHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEE
VNVSLDTLDEKKFADVTRWGRLPQVLRGIDAAQAAGLKIKINAVALKGFNEDELFSMTQW
EEEEHHCCCCHHHHHHHHHCCHHHHHHCCCHHHHCCEEEEEEEEEEECCCHHHHHHHHHH
CADRGIDLTWIEVMPMGDIGNESRLGQYWSLKDVRKAYESGYQVTDLAERTGGPARYVRL
HHHCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHCCCCEEEEEE
EETGQKIGFITPLSHNFCESCNRVRLTCTGELYMCLGQEDMADLRAPLRDHPDTEAPLEE
HHCCCEEEEECCCCHHHHHCCCCEEEEEECEEEEEECCHHHHHHHCHHHCCCCCCCHHHH
AIRAAINLKPKGHDFDYSRQTVDGQMPRHMSHTGG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVRL
CCCCHHHHHHHHHHHEEEECCCCCCEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHHH
GVEKLRITGGEPLVRRDIMTFFRSMTRHLDSGALKELTLTTNGSQLEKHAQALYDAGVRR
CHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEE
VNVSLDTLDEKKFADVTRWGRLPQVLRGIDAAQAAGLKIKINAVALKGFNEDELFSMTQW
EEEEHHCCCCHHHHHHHHHCCHHHHHHCCCHHHHCCEEEEEEEEEEECCCHHHHHHHHHH
CADRGIDLTWIEVMPMGDIGNESRLGQYWSLKDVRKAYESGYQVTDLAERTGGPARYVRL
HHHCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHCCCCEEEEEE
EETGQKIGFITPLSHNFCESCNRVRLTCTGELYMCLGQEDMADLRAPLRDHPDTEAPLEE
HHCCCEEEEECCCCHHHHHCCCCEEEEEECEEEEEECCHHHHHHHCHHHCCCCCCCHHHH
AIRAAINLKPKGHDFDYSRQTVDGQMPRHMSHTGG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA