Click here to switch to the map view.

The map label for this gene is cof [H]

Identifier: 94985837

GI number: 94985837

Start: 1845308

End: 1846153

Strand: Reverse

Name: cof [H]

Synonym: Dgeo_1737

Alternate gene names: 94985837

Gene position: 1846153-1845308 (Counterclockwise)

Preceding gene: 94985838

Following gene: 94985819

Centisome position: 74.83

GC content: 67.73

Gene sequence:

>846_bases
GTGGGCGGTTTTTCTTTTTCTCTTGGCGCTGCTAGGCTGCCGCTCGTGCGTGCTCGTCTCCCTGCCGACCTCCCGCTGCT
GCTCGCCTTTGACCTCGACGGAACCCTGATCCCCGATCAGGGCCGAGAGGTGCCTGGCCCCACGGCGGAGGCGCTCGTCC
GGCTGCGGGCGCTGGGTGTGCGGCTCGCGATCATTACCGGACGGGATACCCCGCCCCGGGCTGTGCGGGAAGCGGTCCAG
CCCGATGCCATCGCCACCAACAACGGTGGACGCGTGGAGATCGGTGGTCAGCTGCACGCAGAGGCCCAGTTCACGCCCGC
CGAGCTGGAGGCGGTGCTGGCACACGAGCTGGAAGATGCCCGCATCGCCGTCTTTACAGCCGATGGGTTGTACGTGGATC
TGCCGCCAGGCCACGCGCCGGAACCCTGGATGCAGGCTCGAGGCTACCGTCCCCTGGCGGAAGCGCCGCGCGAGGGCATC
CTGAAGGTGGGCTTTTACCATCCCGGTGTCGCGGACTTCGCCGCTCGCCTGCGTGAGAGCCACCCCCACCTTGTTCTGAC
GGGTGCCCAGCCTCCCTACAGCGAGTTCTTGACCGTCACGCCGGTGGGCGCGCACAAGGGCGCTGCGCTCACGCTGATCG
CCCAGGCACTGGGCCTTTCCCTGGAACGCACCGTCGCCTTTGGAGACAGTGACAACGATCAGGCGATGTTGGAACTCGCC
GGGTACGCGGTGCAGCTGGGGACCTTACCGCTGCTTGCTCCCCATGCACACGAACAGCTTGCGGGGCCGGAAGCCCTGGG
TGCCTACCTACACGAGCTGGCCGACCGTTTGGAGGGGCGGGGCTAG

Upstream 100 bases:

>100_bases
CGCGGCCCAGGGCAACAGCTCCAGCGAGACTCAGAGCAGCACTGCAGCCGTCGAGACGCAGGGCGAGTAAGCCTTGTAGT
CCTGCCGCCCGCCCCGACCG

Downstream 100 bases:

>100_bases
AGCCTCCCCTGAGCCGCCACCTGACCCCTTTCCAGATGCAAGTGATGCGTGAGTCCCGGCAGGGCGTCTTGCTCGCGGTG
CGCGATCACCATCACGTGGG

Product: HAD family hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MGGFSFSLGAARLPLVRARLPADLPLLLAFDLDGTLIPDQGREVPGPTAEALVRLRALGVRLAIITGRDTPPRAVREAVQ
PDAIATNNGGRVEIGGQLHAEAQFTPAELEAVLAHELEDARIAVFTADGLYVDLPPGHAPEPWMQARGYRPLAEAPREGI
LKVGFYHPGVADFAARLRESHPHLVLTGAQPPYSEFLTVTPVGAHKGAALTLIAQALGLSLERTVAFGDSDNDQAMLELA
GYAVQLGTLPLLAPHAHEQLAGPEALGAYLHELADRLEGRG

Sequences:

>Translated_281_residues
MGGFSFSLGAARLPLVRARLPADLPLLLAFDLDGTLIPDQGREVPGPTAEALVRLRALGVRLAIITGRDTPPRAVREAVQ
PDAIATNNGGRVEIGGQLHAEAQFTPAELEAVLAHELEDARIAVFTADGLYVDLPPGHAPEPWMQARGYRPLAEAPREGI
LKVGFYHPGVADFAARLRESHPHLVLTGAQPPYSEFLTVTPVGAHKGAALTLIAQALGLSLERTVAFGDSDNDQAMLELA
GYAVQLGTLPLLAPHAHEQLAGPEALGAYLHELADRLEGRG
>Mature_280_residues
GGFSFSLGAARLPLVRARLPADLPLLLAFDLDGTLIPDQGREVPGPTAEALVRLRALGVRLAIITGRDTPPRAVREAVQP
DAIATNNGGRVEIGGQLHAEAQFTPAELEAVLAHELEDARIAVFTADGLYVDLPPGHAPEPWMQARGYRPLAEAPREGIL
KVGFYHPGVADFAARLRESHPHLVLTGAQPPYSEFLTVTPVGAHKGAALTLIAQALGLSLERTVAFGDSDNDQAMLELAG
YAVQLGTLPLLAPHAHEQLAGPEALGAYLHELADRLEGRG

Specific function: Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) [H]

COG id: COG0561

COG function: function code R; Predicted hydrolases of the HAD superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. Cof family [H]

Homologues:

Organism=Escherichia coli, GI87081741, Length=241, Percent_Identity=31.9502074688797, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786982, Length=243, Percent_Identity=28.3950617283951, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006379
- InterPro:   IPR000150 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: NA

Molecular weight: Translated: 29763; Mature: 29632

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGFSFSLGAARLPLVRARLPADLPLLLAFDLDGTLIPDQGREVPGPTAEALVRLRALGV
CCCCCCCCCCHHCCHHHHCCCCCCCEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHHCE
RLAIITGRDTPPRAVREAVQPDAIATNNGGRVEIGGQLHAEAQFTPAELEAVLAHELEDA
EEEEEECCCCCHHHHHHHCCCCCEEECCCCEEEECCEEECCCCCCHHHHHHHHHHCCCCC
RIAVFTADGLYVDLPPGHAPEPWMQARGYRPLAEAPREGILKVGFYHPGVADFAARLRES
EEEEEEECCEEEECCCCCCCCHHHHHCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHC
HPHLVLTGAQPPYSEFLTVTPVGAHKGAALTLIAQALGLSLERTVAFGDSDNDQAMLELA
CCCEEEECCCCCHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHH
GYAVQLGTLPLLAPHAHEQLAGPEALGAYLHELADRLEGRG
HHEEEECCCCEECCCCHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GGFSFSLGAARLPLVRARLPADLPLLLAFDLDGTLIPDQGREVPGPTAEALVRLRALGV
CCCCCCCCCHHCCHHHHCCCCCCCEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHHCE
RLAIITGRDTPPRAVREAVQPDAIATNNGGRVEIGGQLHAEAQFTPAELEAVLAHELEDA
EEEEEECCCCCHHHHHHHCCCCCEEECCCCEEEECCEEECCCCCCHHHHHHHHHHCCCCC
RIAVFTADGLYVDLPPGHAPEPWMQARGYRPLAEAPREGILKVGFYHPGVADFAARLRES
EEEEEEECCEEEECCCCCCCCHHHHHCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHC
HPHLVLTGAQPPYSEFLTVTPVGAHKGAALTLIAQALGLSLERTVAFGDSDNDQAMLELA
CCCEEEECCCCCHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHH
GYAVQLGTLPLLAPHAHEQLAGPEALGAYLHELADRLEGRG
HHEEEECCCCEECCCCHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA