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The map label for this gene is ndk [H]

Identifier: 94985789

GI number: 94985789

Start: 1795493

End: 1795942

Strand: Reverse

Name: ndk [H]

Synonym: Dgeo_1689

Alternate gene names: 94985789

Gene position: 1795942-1795493 (Counterclockwise)

Preceding gene: 94985792

Following gene: 94985787

Centisome position: 72.79

GC content: 64.89

Gene sequence:

>450_bases
GTGCCCGCTGGCCCTGCTATCCTCGCCTGCGGTATGGAACGCACCTTTGCCATGATTAAGCCTGACGGCGTCCGCCGCGG
CCTGACGCCCGAGATTCTCGCCCGTATCCAGAAGAAGGGTTACCGTGTGGTGGGCCTCAAGCAGATGCTGATTTCGCGCG
AACTGGCCGAGCGGCACTACGCCGAACACCGCGAGCGCCCCTTCTTCGGGGAACTGGTGGACTTCATCACCAGCGGTCCA
GTGGTCGCCATCGCTCTGGAAGGCGAGAACGCGATCGCGGGTTGGCGCGCGATGATGGGCGCCACCAACCCCGCCAACGC
CGCCCCCGGTACCATCCGCGCTGATTTTGCCACCACGACCGGCGAGAACGTCACCCACGGCAGCGACTCTCCGGAAAGCG
CGGCGCGCGAGCTGAGCCTGTTCTTTAGGGAAGACGAGCTGCTGAAGTAA

Upstream 100 bases:

>100_bases
TGTTGCTTGGTCACTTGTAGGGTGCAGGCAGCGGGGCAGAACGCGCAGTGAGGCCGCTTGGTCGGCGCTCTCCCCGGGCG
GACCTGCAGGTGCTGACGCC

Downstream 100 bases:

>100_bases
GGGTTGGGTTGTCGGCGTCAGGAATGAGGCGTCAGGAATGAGGAAGGGGGCAGGCTTTCGCTCAGGCGGAGGCCTGTCCT
CTGCTTTGTCTCACTCCTCA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MPAGPAILACGMERTFAMIKPDGVRRGLTPEILARIQKKGYRVVGLKQMLISRELAERHYAEHRERPFFGELVDFITSGP
VVAIALEGENAIAGWRAMMGATNPANAAPGTIRADFATTTGENVTHGSDSPESAARELSLFFREDELLK

Sequences:

>Translated_149_residues
MPAGPAILACGMERTFAMIKPDGVRRGLTPEILARIQKKGYRVVGLKQMLISRELAERHYAEHRERPFFGELVDFITSGP
VVAIALEGENAIAGWRAMMGATNPANAAPGTIRADFATTTGENVTHGSDSPESAARELSLFFREDELLK
>Mature_148_residues
PAGPAILACGMERTFAMIKPDGVRRGLTPEILARIQKKGYRVVGLKQMLISRELAERHYAEHRERPFFGELVDFITSGPV
VAIALEGENAIAGWRAMMGATNPANAAPGTIRADFATTTGENVTHGSDSPESAARELSLFFREDELLK

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=144, Percent_Identity=54.1666666666667, Blast_Score=161, Evalue=2e-40,
Organism=Homo sapiens, GI38045913, Length=151, Percent_Identity=50.3311258278146, Blast_Score=159, Evalue=9e-40,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=52.9411764705882, Blast_Score=156, Evalue=6e-39,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=50.3649635036496, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=50.3649635036496, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=50.3649635036496, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=50.3649635036496, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=50.3649635036496, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=43.0656934306569, Blast_Score=130, Evalue=6e-31,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=42.1052631578947, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=42.1052631578947, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=39.7058823529412, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=33.0882352941176, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=27.536231884058, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=34.0740740740741, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=52.2058823529412, Blast_Score=147, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=48.8888888888889, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322783, Length=141, Percent_Identity=48.936170212766, Blast_Score=155, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45549037, Length=143, Percent_Identity=51.0489510489511, Blast_Score=159, Evalue=6e-40,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=36.7647058823529, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16227; Mature: 16096

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAGPAILACGMERTFAMIKPDGVRRGLTPEILARIQKKGYRVVGLKQMLISRELAERHY
CCCCCEEEEECCCHHEEEECCCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
AEHRERPFFGELVDFITSGPVVAIALEGENAIAGWRAMMGATNPANAAPGTIRADFATTT
HHHCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCC
GENVTHGSDSPESAARELSLFFREDELLK
CCCCCCCCCCHHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure 
PAGPAILACGMERTFAMIKPDGVRRGLTPEILARIQKKGYRVVGLKQMLISRELAERHY
CCCCEEEEECCCHHEEEECCCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
AEHRERPFFGELVDFITSGPVVAIALEGENAIAGWRAMMGATNPANAAPGTIRADFATTT
HHHCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCC
GENVTHGSDSPESAARELSLFFREDELLK
CCCCCCCCCCHHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA