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The map label for this gene is trpC [H]

Identifier: 94985687

GI number: 94985687

Start: 1688426

End: 1689214

Strand: Reverse

Name: trpC [H]

Synonym: Dgeo_1587

Alternate gene names: 94985687

Gene position: 1689214-1688426 (Counterclockwise)

Preceding gene: 94985693

Following gene: 94985686

Centisome position: 68.47

GC content: 71.48

Gene sequence:

>789_bases
ATGACAGGCCTGCCGGTGACCCACTTTGAGCGCGTGCCAGGTGTCCTGGGCCGGATTGTCCGCGAGCGCGCCGCCGATTA
CGCGGATGCGAACACGGACCTGGGACCCGCACGCCCCCGCGCCGGGAGGTTCCGCGCGGCCCTCGCTCGCCCTCACCTCG
CCTTGATCGCGGAAGTCAAACGGGCCAGCCCCAGCGAGGGTGCAATCGCGCCGCTCGACCCAGCCCGCGCCGCTCGTGCT
TATGCGGCGGGCGGCGCGGCGGCCATCAGCGTTCTGACCGAGCCCCGGCACTTCGACGGCAACCGGGAGGCGCTGCAGGC
GGTGGTGGGTGCCGTCGAGCTTCCGGTCCTGCGCAAGGATTTCGTCGTCCATCCAGCCATGCTGCGTGAGGCAGCCGACT
GGGGCGCTGCCGCCGCCCTCCTGATGGTCAGCGTGCTGGGCGAGGCGGTCGGTGCGTATCTGGACATGGCACACCACCTT
GGCCTCGACGCGCTGGTGGAGGTCCACGACGAGCGCGAACTGGAGGTGGCCCTCGCCTCCGGTGCCCAGATCATCGGTGT
CAACAACCGCGACCTCACCACGCTCGCCACCAACCTCGCCGTCAGTCCGCGGCTAATCCGCCGGGCACGCGAGGCAGGCT
TTGGCGGCGTGCTGGTCGCGGAGAGCGGCTACCGCACGCCCGCCGACCTGGAGAGCGTGCGTGACCTGGCAGACGCCGTG
CTGGTCGGCACCAGTCTGGCCGCCAGCGGCGACCTGACCCGCGCCGCGCGCGAGCTGATGACCCCTTGA

Upstream 100 bases:

>100_bases
ATTGCCGGGGGCGAGGCTCATATCGGCCTAGGCTAACACGCGCTCCCCCGTCTGTAACCTCTCTGGCCGCGTGAACGCCG
GCGCCCGTATACTCCAGCGC

Downstream 100 bases:

>100_bases
ACGGCACGCTCACCTTTTTGGGCAGCGCCGACAGCAAGGGCGTCCCGCGCTTCTGGTGTGACTGCCCGGTCTGTGCTGAG
GCCCGCACGAGCGGCGTCAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTGLPVTHFERVPGVLGRIVRERAADYADANTDLGPARPRAGRFRAALARPHLALIAEVKRASPSEGAIAPLDPARAARA
YAAGGAAAISVLTEPRHFDGNREALQAVVGAVELPVLRKDFVVHPAMLREAADWGAAAALLMVSVLGEAVGAYLDMAHHL
GLDALVEVHDERELEVALASGAQIIGVNNRDLTTLATNLAVSPRLIRRAREAGFGGVLVAESGYRTPADLESVRDLADAV
LVGTSLAASGDLTRAARELMTP

Sequences:

>Translated_262_residues
MTGLPVTHFERVPGVLGRIVRERAADYADANTDLGPARPRAGRFRAALARPHLALIAEVKRASPSEGAIAPLDPARAARA
YAAGGAAAISVLTEPRHFDGNREALQAVVGAVELPVLRKDFVVHPAMLREAADWGAAAALLMVSVLGEAVGAYLDMAHHL
GLDALVEVHDERELEVALASGAQIIGVNNRDLTTLATNLAVSPRLIRRAREAGFGGVLVAESGYRTPADLESVRDLADAV
LVGTSLAASGDLTRAARELMTP
>Mature_261_residues
TGLPVTHFERVPGVLGRIVRERAADYADANTDLGPARPRAGRFRAALARPHLALIAEVKRASPSEGAIAPLDPARAARAY
AAGGAAAISVLTEPRHFDGNREALQAVVGAVELPVLRKDFVVHPAMLREAADWGAAAALLMVSVLGEAVGAYLDMAHHLG
LDALVEVHDERELEVALASGAQIIGVNNRDLTTLATNLAVSPRLIRRAREAGFGGVLVAESGYRTPADLESVRDLADAVL
VGTSLAASGDLTRAARELMTP

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=255, Percent_Identity=36.078431372549, Blast_Score=125, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322638, Length=244, Percent_Identity=36.0655737704918, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 27460; Mature: 27329

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLPVTHFERVPGVLGRIVRERAADYADANTDLGPARPRAGRFRAALARPHLALIAEVK
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
RASPSEGAIAPLDPARAARAYAAGGAAAISVLTEPRHFDGNREALQAVVGAVELPVLRKD
HCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHH
FVVHPAMLREAADWGAAAALLMVSVLGEAVGAYLDMAHHLGLDALVEVHDERELEVALAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHEEHHHC
GAQIIGVNNRDLTTLATNLAVSPRLIRRAREAGFGGVLVAESGYRTPADLESVRDLADAV
CCEEEECCCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHH
LVGTSLAASGDLTRAARELMTP
HHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TGLPVTHFERVPGVLGRIVRERAADYADANTDLGPARPRAGRFRAALARPHLALIAEVK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
RASPSEGAIAPLDPARAARAYAAGGAAAISVLTEPRHFDGNREALQAVVGAVELPVLRKD
HCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHH
FVVHPAMLREAADWGAAAALLMVSVLGEAVGAYLDMAHHLGLDALVEVHDERELEVALAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHEEHHHC
GAQIIGVNNRDLTTLATNLAVSPRLIRRAREAGFGGVLVAESGYRTPADLESVRDLADAV
CCEEEECCCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHH
LVGTSLAASGDLTRAARELMTP
HHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]